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Research Article

Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae β-carbonic anhydrase

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Pages 495-499 | Received 11 Apr 2013, Accepted 16 May 2013, Published online: 01 Jul 2013

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Siham A. Alissa, Hanan A. Alghulikah, Zeid A. ALOthman, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, Alessio Nocentini & Claudiu T. Supuran. (2020) Inhibition survey with phenolic compounds against the δ- and η-class carbonic anhydrases from the marine diatom thalassiosira weissflogii and protozoan Plasmodium falciparum. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 377-382.
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Sinan Bilginer, Baris Gonder, Halise Inci Gul, Ruya Kaya, Ilhami Gulcin, Baris Anil & Claudiu T. Supuran. (2020) Novel sulphonamides incorporating triazene moieties show powerful carbonic anhydrase I and II inhibitory properties. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 325-329.
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Halise Inci Gul, Cem Yamali, Fatma Yesilyurt, Hiroshi Sakagami, Kaan Kucukoglu, Ilhami Gulcin, Mustafa Gul & Claudiu T. Supuran. (2017) Microwave-assisted synthesis and bioevaluation of new sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 369-374.
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Halise Inci Gul, Ebru Mete, Sakip Emre Eren, Hiroshi Sakagami, Cem Yamali & Claudiu T. Supuran. (2017) Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 169-175.
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Cem Yamali, Halise Inci Gul, Hiroshi Sakagami & Claudiu T. Supuran. (2016) Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 125-131.
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Elif Unluer, Halise Inci Gul, Alkan Demirtas, Hiroshi Sakagami, Naoki Umemura, Muhammet Tanc, Cavit Kazaz & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 105-109.
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Halise Inci Gul, Mehtap Tugrak, Hiroshi Sakagami, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1619-1624.
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Halise Inci Gul, Cem Yamali, Asiye Tugce Yasa, Elif Unluer, Hiroshi Sakagami, Muhammet Tanc & Claudiu T. Supuran. (2016) Carbonic anhydrase inhibition and cytotoxicity studies of Mannich base derivatives of thymol. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1375-1380.
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Cem Yamali, Mehtap Tugrak, Halise Inci Gul, Muhammet Tanc & Claudiu T. Supuran. (2016) The inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1678-1681.
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İlhami Gülçin, Andrea Scozzafava, Claudiu T. Supuran, Hulya Akıncıoğlu, Zeynep Koksal, Fikret Turkan & Saleh Alwasel. (2016) The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1095-1101.
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Ozen Ozensoy Guler, Clemente Capasso & Claudiu T. Supuran. (2016) A magnificent enzyme superfamily: carbonic anhydrases, their purification and characterization. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 689-694.
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György M. Buzás & Claudiu T. Supuran. (2016) The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puşcaş (1932–2015). Journal of Enzyme Inhibition and Medicinal Chemistry 31:4, pages 527-533.
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Murat Bozdag, Fabrizio Carta, Daniela Vullo, Semra Isik, Zeid AlOthman, Sameh M. Osman, Andrea Scozzafava & Claudiu T. Supuran. (2016) Dithiocarbamates with potent inhibitory activity against the Saccharomyces cerevisiae β-carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry 31:1, pages 132-136.
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Andrea Scozzafava, Pınar Kalın, Claudiu T. Supuran, İlhami Gülçin & Saleh H. Alwasel. (2015) The impact of hydroquinone on acetylcholine esterase and certain human carbonic anhydrase isoenzymes (hCA I, II, IX, and XII). Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 941-946.
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Leonardo E. Riafrecha, Daniela Vullo, Safia Ouahrani-Bettache, Stephan Köhler, Pascal Dumy, Jean-Yves Winum, Claudiu T. Supuran & Pedro A. Colinas. (2015) Inhibition of β-carbonic anhydrases from Brucella suis with C-cinnamoyl glycosides incorporating the phenol moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 1017-1020.
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Joanna Ombouma, Daniela Vullo, Stephan Köhler, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2015) N-glycosyl-N-hydroxysulfamides as potent inhibitors of Brucella suis carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 1010-1012.
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Namrata Singasane, Prashant S. Kharkar, Mariangela Ceruso, Claudiu T. Supuran & Mrunmayee P. Toraskar. (2015) Inhibition of carbonic anhydrase isoforms I, II, IX and XII with Schiff’s bases incorporating iminoureido moieties. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 901-907.
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Mehmet Arslan, Murat Şentürk, İsmail Fidan, Oktay Talaz, Deniz Ekinci, Sedat Coşgun & Claudiu T. Supuran. (2015) Synthesis of 3,4-dihydroxypyrrolidine-2,5-dione and 3,5-dihydroxybenzoic acid derivatives and evaluation of the carbonic anhydrase I and II inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 30:6, pages 896-900.
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Daniela Vullo, Semra Isik, Murat Bozdag, Fabrizio Carta & Claudiu T. Supuran. (2015) 7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring. Journal of Enzyme Inhibition and Medicinal Chemistry 30:5, pages 773-777.
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Andrea Scozzafava, Maurizio Passaponti, Claudiu T. Supuran & İlhami Gülçin. (2015) Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII). Journal of Enzyme Inhibition and Medicinal Chemistry 30:4, pages 586-591.
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Claudia Palmer & Claudiu T Supuran. (2015) A Key Opinion Leader interview: insight into the research and career of Prof. Claudiu T Supuran. Expert Opinion on Therapeutic Patents 25:4, pages 501-505.
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Viviana De Luca, Sonia Del Prete, Claudiu T. Supuran & Clemente Capasso. (2015) Protonography, a new technique for the analysis of carbonic anhydrase activity. Journal of Enzyme Inhibition and Medicinal Chemistry 30:2, pages 277-282.
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Jekaterīna Ivanova, Fabrizio Carta, Daniela Vullo, Janis Leitans, Andris Kazaks, Kaspars Tars, Raivis Žalubovskis & Claudiu T. Supuran. (2017) N -Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII. Bioorganic & Medicinal Chemistry 25:13, pages 3583-3589.
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Fabrizio Carta, Daniela Vullo, Sameh M. Osman, Zeid AlOthman & Claudiu T. Supuran. (2017) Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs. Bioorganic & Medicinal Chemistry 25:9, pages 2569-2576.
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Yeganeh Entezari Heravi, Silvia Bua, Alessio Nocentini, Sonia Del Prete, Ali Akbar Saboury, Hassan Sereshti, Clemente Capasso, Paola Gratteri & Claudiu T. Supuran. (2017) Inhibition of Malassezia globosa carbonic anhydrase with phenols. Bioorganic & Medicinal Chemistry 25:9, pages 2577-2582.
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Vito Coviello, Beatrice Marchi, Stefania Sartini, Luca Quattrini, Anna Maria Marini, Francesca Simorini, Sabrina Taliani, Silvia Salerno, Paola Orlandi, Anna Fioravanti, Teresa Di Desidero, Daniela Vullo, Federico Da Settimo, Claudiu T. Supuran, Guido Bocci & Concettina La Motta. (2016) 1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions. Journal of Medicinal Chemistry 59:13, pages 6547-6552.
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Mustafa Durgun, Hasan Turkmen, Mariangela Ceruso & Claudiu T. Supuran. (2016) Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII. Bioorganic & Medicinal Chemistry 24:5, pages 982-988.
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