2,664
Views
47
CrossRef citations to date
0
Altmetric
Research Article

Synthesis and characterization of quinazoline derivatives: search for hybrid molecule as diuretic and antihypertensive agents

, , , &
Pages 733-743 | Received 24 Jul 2013, Accepted 15 Sep 2013, Published online: 24 Oct 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Oussama Dehbi, Yassine Riadi, Mohammed H. Geesi, El Hassane Anouar, Elmutasim O. Ibnouf & Rachid Azzallou. (2023) Synthesis, Characterization, Antibacterial Evaluation, and Molecular Docking of New Quinazolinone-Based Derivatives. Polycyclic Aromatic Compounds 43:2, pages 1879-1887.
Read now
Amr H. Moustafa & Bahgat R. M. Hussein. (2022) A methodological approach for the synthesis of 4-aryl-8-arylidene-2-cyanoimino-1,2,3,4,5,6,7,8-octahydroquinazolines. Synthetic Communications 52:8, pages 1131-1138.
Read now
Halise Inci Gul, Ebru Mete, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran. (2017) Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines . Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 189-192.
Read now

Articles from other publishers (43)

Ayesha Rafiq, Sana Aslam, Matloob Ahmad, Muhammad Jawwad Saif, Sami A. Al-Hussain & Magdi E.A. Zaki. 2024. Recent Advances on Quinazoline [Working Title]. Recent Advances on Quinazoline [Working Title].
Nagaraju Myakala, Kotaiah Kandula, Nagamani Rayala, Sateesh Kuna, Vishnu Thumma & Kanaka Durga Bhavani Anagani. (2023) Design, Synthesis of Novel 1,2,3‐Triazole Pendent Quinazolinones and Their Cytotoxicity against MCF‐7 Cell Line. Chemistry & Biodiversity.
Crossref
Zahra Alishahi, Morteza Torabi, Mohammad Ali Zolfigol & Meysam Yarie. (2023) Nanoarchitectonics of magnetic covalent organic framework with sulfonic acid tags for catalytic preparation of triazolo quinazolinones and 4H-pyrimidobenzothiazoles. Journal of Solid State Chemistry 324, pages 124119.
Crossref
Aditya Raj, Adarsh Kumar, Ankit Kumar Singh, Harshwardhan Singh, Suresh Thareja & Pradeep Kumar. (2023) Synthetic Methodologies and SAR of Quinazoline Derivatives as PI3K Inhibitors. Anti-Cancer Agents in Medicinal Chemistry 23:9, pages 1013-1047.
Crossref
Rekha Tamatam, Seok-Ho Kim & Dongyun Shin. (2023) Transition-metal-catalyzed synthesis of quinazolines: A review. Frontiers in Chemistry 11.
Crossref
Naman Jain, Tanvi Goel, Snehal Thakar, Madhav Jadhav & Deepali Bansode. (2023) An Explicative Review on the Progress of Quinazoline Scaffold as Bioactive Agents in the Past Decade. Medicinal Chemistry 19:3, pages 211-245.
Crossref
Shizuki Noda & Shinji Tanimori. (2023) Organic solvent-free synthesis of sulfonyl hydrazides in water. Tetrahedron Green Chem 1, pages 100001.
Crossref
Sharmila Gote, Shankar Thapa, Sonal Dubey, Shachindra L. Nargund & Mahalakshmi Suresha Biradar. (2023) Computational investigation of quinazoline derivatives as Keap1 inhibitors for Alzheimer's disease. Informatics in Medicine Unlocked 41, pages 101334.
Crossref
Ramakant A. Kardile, Aniket P. Sarkate, Deepak K. Lokwani, Shailee V. Tiwari, Rajaram Azad & Shankar R. Thopate. (2023) Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening and ADME predictions. European Journal of Medicinal Chemistry 245, pages 114889.
Crossref
Tukaram V. Metre, Barnabas Kodasi, Praveen K. Bayannavar, Lokesh Bheemayya, Vishwa B. Nadoni, Swati R. Hoolageri, Arun K. Shettar, Shrinivas D. Joshi, Vijay M. Kumbar & Ravindra R. Kamble. (2023) Coumarin-4-yl‐1,2,3‐triazol‐4-yl-methyl-thiazolidine-2,4-diones: Synthesis, glucose uptake activity and cytotoxic evaluation. Bioorganic Chemistry 130, pages 106235.
Crossref
D. Honglin, G. Chao, S. Xiaojie, Z. Yutong, W. Zhengjie, L. Limin, W. Tao, Z. Luye, Z. Yang, Y. Qin, Z. Peirong, S. Lihong & Z. Qiurong. (2022) Design, Synthesis, and Antitumor Activity Evaluation of 2,4,6-Trisubstituted Quinazoline Derivatives Containing Acrylamide. Russian Journal of Bioorganic Chemistry 48:5, pages 1089-1100.
Crossref
Harekrishna Roy, Bhabani Shankar Nayak, Balaji Maddiboyina & Sisir Nandi. (2022) Chitosan based urapidil microparticle development in approach to improve mechanical strength by cold hyperosmotic dextrose solution technique. Journal of Drug Delivery Science and Technology 76, pages 103745.
Crossref
Katharigatta N. Venugopala, Nizar A. Al-Shar’i, Lina A. Dahabiyeh, Wafa Hourani, Pran Kishore Deb, Melendhran Pillay, Bashaer Abu-Irmaileh, Yasser Bustanji, Sandeep Chandrashekharappa, Christophe Tratrat, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Pottathil Shinu, Michelyne Haroun, Mahmoud Kandeel, Abdulmalek Ahmed Balgoname, Rashmi Venugopala & Mohamed A. Morsy. (2022) Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives. Antibiotics 11:7, pages 831.
Crossref
Sitanshu Kumar, Surabhi Mangal, Anu Nosran, Kusum Harjai & Vasundhara Singh. (2022) Synthesis of Bis(indolyl)methane/Dihydropyrimidinone Tethered Bis‐Amidic Triazole Hybrid Compounds via One‐Pot Sequential Six/Seven Component Ugi‐Click Reaction. ChemistrySelect 7:17.
Crossref
Eman M. Fathalla, Mezna Saleh Altowyan, Jörg H. Albering, Assem Barakat, Morsy A. M. Abu-Youssef, Saied M. Soliman & Ahmed M. A. Badr. (2022) Synthesis, X-ray Structure, Hirshfeld, DFT and Biological Studies on a Quinazolinone-Nitrate Complex. Molecules 27:3, pages 1089.
Crossref
Simranpreet K. Wahan, Bharti Sharma & Pooja A. Chawla. (2021) Medicinal perspective of quinazolinone derivatives: Recent developments and structure–activity relationship studies . Journal of Heterocyclic Chemistry 59:2, pages 239-257.
Crossref
Parleen Kaur, Swati Sihag, Monika Chauhan, Neelima Dhingra, Navneet Agnihotri, Ramandeep Kaur & Vasundhara Singh. (2022) Synthesis and In Vitro Analysis of 1‐Deoxysphingolipid Ceramide Analogues via UGI Reaction as Potential Anti‐cancer Agents. ChemistrySelect 7:2.
Crossref
Rameshwar S. Cheke, Sachin D. Shinde, Jaya P. Ambhore, Suraj R. Chaudhari & Sanjay B. Bari. (2022) Quinazoline: An update on current status against convulsions. Journal of Molecular Structure 1248, pages 131384.
Crossref
Aiten M. Soliman, Amira Khalil, Eman Ramadan & Mostafa M. Ghorab. (2021) Induction of apoptosis, cytotoxicity and radiosensitization by novel 3,4-dihydroquinazolinone derivatives. Bioorganic & Medicinal Chemistry Letters 49, pages 128308.
Crossref
Kshipra S. Karnik, Aniket P. Sarkate, Shailee V. Tiwari, Rajaram Azad & Pravin S. Wakte. (2021) Free energy perturbation guided Synthesis with Biological Evaluation of Substituted Quinoline derivatives as small molecule L858R/T790M/C797S mutant EGFR inhibitors targeting resistance in Non-Small Cell Lung Cancer (NSCLC). Bioorganic Chemistry 115, pages 105226.
Crossref
Pradip Ramdas Thorve & Biplab Maji. (2021) Aerobic primary and secondary amine oxidation cascade by a copper amine oxidase inspired catalyst. Catalysis Science & Technology 11:3, pages 1116-1124.
Crossref
Ranju Bansal & Anjleena Malhotra. (2021) Therapeutic progression of quinazolines as targeted chemotherapeutic agents. European Journal of Medicinal Chemistry 211, pages 113016.
Crossref
Mohan Babu Bommagani, Jayaprakash Rao Yerrabelly, Manasa Chitneni, Gangadhar Thalari, Naveen Reddy Vadiyala, Sathish Kumar Boda & Prasad Rao Chitneni. (2021) Synthesis and antibacterial activity of novel cinnoline-isoxazole derivatives. Chemical Data Collections 31, pages 100629.
Crossref
Abdelmalek Khorief Nacereddine. (2020) A MEDT computational study of the mechanism, reactivity and selectivity of non-polar [3+2] cycloaddition between quinazoline-3-oxide and methyl 3-methoxyacrylate. Journal of Molecular Modeling 26:11.
Crossref
Mohammed H. Geesi, Yassine Riadi, Abdellah Kaiba, El Hassane Anouar, Oussama Ouerghi, Elmutasim O. Ibnouf & Philipe Guionneau. (2020) Synthesis, antibacterial evaluation, Raman, Crystal Structure and Hirshfeld Surface analysis of a new 3-(4-fluorophenyl)-6-methyl-2-(propylthio)quinazolin-4(3H)-one. Journal of Molecular Structure 1215, pages 128265.
Crossref
You-Guang Zheng, Wu-Qi Zhang, Long Meng, Xiao-Qing Wu, Ling Zhang, Lin An, Cheng-Lin Li, Cai-Yun Gao, Liang Xu & Yi Liu. (2020) Design, synthesis and biological evaluation of 4-aniline quinazoline derivatives conjugated with hydrogen sulfide (H2S) donors as potent EGFR inhibitors against L858R resistance mutation. European Journal of Medicinal Chemistry 202, pages 112522.
Crossref
Wenyan Hao, Zhaotao Xu, Zebiao Zhou & Mingzhong Cai. (2020) Recyclable Heterogeneous Palladium-Catalyzed Cyclocarbonylation of 2-Iodoanilines with Acyl Chlorides in the Biomass-Derived Solvent 2-Methyltetrahydrofuran. The Journal of Organic Chemistry 85:13, pages 8522-8532.
Crossref
Krishna Murthy Potla, Nuthalapati Poojith, Francisco A.P. Osório, Clodoaldo Valverde, Sampath Chinnam, P.A. Suchetan & Suneetha Vankayalapati. (2020) An analysis of spectroscopic, computational and biological activity studies of L-shaped sulfamoylbenzoic acid derivatives: A third order nonlinear optical material. Journal of Molecular Structure 1210, pages 128070.
Crossref
Awwad A. Radwan & Fars K. Alanazi. 2020. Quinazolinone and Quinazoline Derivatives. Quinazolinone and Quinazoline Derivatives.
Katharigatta N. Venugopala, Pushpalatha Ramachandra, Christophe Tratrat, Raquel M. Gleiser, Subhrajyoti Bhandary, Deepak Chopra, Mohamed A. Morsy, Bandar E. Aldhubiab, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Rashmi Venugopala, Pran Kishore Deb, Sandeep Chandrashekharappa, Hany Ezzat Khalil, Osama I. Alwassil, Sara Nidal Abed, Yazan A. Bataineh, Ramachandra Palenge, Michelyne Haroun, Shinu Pottathil, Meravanige B. Girish, Sabah H. Akrawi & Viresh Mohanlall. (2020) Larvicidal Activities of 2-Aryl-2,3-Dihydroquinazolin -4-ones against Malaria Vector Anopheles arabiensis, In Silico ADMET Prediction and Molecular Target Investigation. Molecules 25:6, pages 1316.
Crossref
Sara Oudi, Ali Reza Oveisi, Saba Daliran, Mostafa Khajeh & Elias Teymoori. (2020) Brønsted-Lewis dual acid sites in a chromium-based metal-organic framework for cooperative catalysis: Highly efficient synthesis of quinazolin-(4H)-1-one derivatives. Journal of Colloid and Interface Science 561, pages 782-792.
Crossref
Sourav Ghorai, Yongjia Lin, Yuanzhi Xia, Donald J. Wink & Daesung Lee. (2019) Silver-Catalyzed Annulation of Arynes with Nitriles for Synthesis of Structurally Diverse Quinazolines. Organic Letters 22:2, pages 626-630.
Crossref
Qing-Su Long, Li-Wei Liu, Yong-Liang Zhao, Pei-Yi Wang, Biao Chen, Zhong Li & Song Yang. (2019) Fabrication of Furan-Functionalized Quinazoline Hybrids: Their Antibacterial Evaluation, Quantitative Proteomics, and Induced Phytopathogen Morphological Variation Studies. Journal of Agricultural and Food Chemistry 67:40, pages 11005-11017.
Crossref
Marta Szumilak, Anna Lichota, Andrzej Olczak, Małgorzata Szczesio & Andrzej Stańczak. (2019) Molecular insight into quinazoline derivatives with cytotoxic activity. Journal of Molecular Structure 1194, pages 28-34.
Crossref
Shilpa M. Somagond, Ravindra R. Kamble, Praveen K. Bayannavar, Saba Kauser J. Shaikh, Shrinivas D. Joshi, Vijay M. Kumbar, Aravind R. Nesaragi & Mahadevappa Y. Kariduraganavar. (2019) Click chemistry based regioselective one‐pot synthesis of coumarin‐3‐yl‐methyl‐1,2,3‐triazolyl‐1,2,4‐triazol‐3(4 H )‐ones as newer potent antitubercular agents . Archiv der Pharmazie 352:10.
Crossref
Galal H. Elgemeie, Rasha A. Azzam & Rasha E. Elsayed. (2019) Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018). Medicinal Chemistry Research 28:8, pages 1099-1131.
Crossref
Mohammed B. Alshammari, Mohammed H. Geesi, El Hassane Anouar, Rashad Al-Salahi, Abdulrahman I. Alharthi, Yasser Elnakady & Mohamed Marzouk. (2018) Quantum Chemical Calculations and Statistical Analysis: Structural Cytotoxicity Relationships of some Synthesized 2-thiophen-naphtho(benzo)oxazinone Derivatives. Cell Biochemistry and Biophysics 76:3, pages 377-389.
Crossref
Hanane Kaoukabi, Youssef Kabri, Christophe Curti, Moha Taourirte, Juan C. Rodriguez-Ubis, Robert Snoeck, Graciela Andrei, Patrice Vanelle & Hassan B. Lazrek. (2018) Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation. European Journal of Medicinal Chemistry 155, pages 772-781.
Crossref
Raghad M Nowar, Essam Eldin A Osman, Sahar M Abou-Seri, Samir M El Moghazy & Dalal A Abou El Ella. (2018) Design, synthesis and biological evaluation of some novel quinazolinone derivatives as potent apoptotic inducers. Future Medicinal Chemistry 10:10, pages 1191-1205.
Crossref
Kuppusamy Bharathimohan, Thanasekaran Ponpandian & Ahamed A. Jafar. (2017) Silver-Mediated Synthesis of 4 H -Benzoxazin-4-ones by Intramolecular Decarboxylative O -Acylation Reactions with α-Oxocarboxylic Acid . European Journal of Organic Chemistry 2017:19, pages 2806-2813.
Crossref
You-Guang Zheng, Jun Su, Cai-Yun Gao, Ping Jiang, Lin An, Yun-Sheng Xue, Jian Gao & Yi Liu. (2017) Design, synthesis, and biological evaluation of novel 4-anilinoquinazoline derivatives bearing amino acid moiety as potential EGFR kinase inhibitors. European Journal of Medicinal Chemistry 130, pages 393-405.
Crossref
Soňa Jantová, Martina Melušová, Miroslav Pánik, Vlasta Brezová & Zuzana Barbieriková. (2016) UVA-induced effects of 2,6-disubstituted 4-anilinoquinazolines on cancer cell lines. Journal of Photochemistry and Photobiology B: Biology 154, pages 77-88.
Crossref
Gabriela Souza Fernandes, Michelle Bueno de Moura Pereira, Ana Cláudia Barbosa Marinho, Brisa Machado, Ana Carla Moreira, Matheus Puggina de Freitas, Karen Luise Lang & João Eustáquio Antunes. (2015) In <i>Silico</i> Pharmacokinetics Studies for Quinazolines Proposed as EGFR Inhibitors. Open Journal of Medicinal Chemistry 05:04, pages 106-115.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.