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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 30, 2015 - Issue 4
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Original Articles

A new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase from Trypanosoma cruzi

Ahmed M. AlafeefyDepartment of Pharmaceutical Chemistry, College of Pharmacy, Salman bin Abdulaziz University, Al-Kharj, Saudi Arabia, Correspondence[email protected]
,
Mariangela CerusoPolo Scientifico, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy, Correspondence[email protected]
,
Nabila A. Al-JaberChemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia,
,
Seppo ParkkilaSchool of Medicine and Fimlab Ltd, University of Tampere, Tampere, Finland,
,
Alane Beatriz VermelhoLaboratório Proteases de Microrganismos, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, and
&
Claudiu T. SupuranPolo Scientifico, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino, Florence, Italy, ;Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Florence, Italy
Pages 581-585 | Received 30 Jul 2014, Accepted 16 Aug 2014, Published online: 06 Nov 2014

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Akash Pratap Singh, Shaban Ahmad, Khalid Raza & Hemant K. Gautam. (2023) Computational screening and MM/GBSA-based MD simulation studies reveal the high binding potential of FDA-approved drugs against Cutibacterium acnes sialidase. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-11.
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Hossam Nada, Ahmed Elkamhawy, Magda H. Abdellattif, Andrea Angeli, Chang Hoon Lee, Claudiu T. Supuran & Kyeong Lee. (2022) 4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 994-1004.
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Alane Beatriz Vermelho, Giseli Capaci Rodrigues, Alessio Nocentini, Felipe R. P. Mansoldo & Claudiu T. Supuran. (2022) Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?. Expert Opinion on Drug Discovery 17:10, pages 1147-1158.
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Alessio Nocentini, Sameh M. Osman, Igor A. Rodrigues, Veronica S. Cardoso, Fatmah Ali S. Alasmary, Zeid AlOthman, Alane B. Vermelho, Paola Gratteri & Claudiu T. Supuran. (2019) Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1164-1171.
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Alessio Nocentini, Roberta Cadoni, Pascal Dumy, Claudiu T. Supuran & Jean-Yves Winum. (2018) Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 286-289.
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Sonia Del Prete, Viviana De Luca, Giuseppina De Simone, Claudiu T. Supuran & Clemente Capasso. (2016) Cloning, expression and purification of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 54-59.
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Jorge R. A. Diaz, Martín Fernández Baldo, Gustavo Echeverría, Héctor Baldoni, Daniela Vullo, Delia B. Soria, Claudiu T. Supuran & Gerardo E. Camí. (2016) A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup2, pages 51-62.
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Jorge R. A. Diaz, Gerardo Enrique Camí, Malva Liu-González, Daniel R. Vega, Daniela Vullo, Américo Juárez, José C. Pedregosa & Claudiu T. Supuran. (2016) Salts of 5-amino-2-sulfonamide-1,3,4-thiadiazole, a structural and analog of acetazolamide, show interesting carbonic anhydrase inhibitory properties, diuretic, and anticonvulsant action. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1102-1110.
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İlhami Gülçin, Andrea Scozzafava, Claudiu T. Supuran, Hulya Akıncıoğlu, Zeynep Koksal, Fikret Turkan & Saleh Alwasel. (2016) The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1095-1101.
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Articles from other publishers (17)

Dimitrios Moianos, Georgia-Myrto Prifti, Maria Makri & Grigoris Zoidis. (2023) Targeting Metalloenzymes: The “Achilles’ Heel” of Viruses and Parasites. Pharmaceuticals 16:6, pages 901.
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Reihane Ghomashi, Shakila Ghomashi, Hamidreza Aghaei & Ahmad Reza Massah. (2023) Recent Advances in Biological Active Sulfonamide based Hybrid Compounds Part A: Two-Component Sulfonamide Hybrids. Current Medicinal Chemistry 30:4, pages 407-480.
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Farhana Hakim, Roshan Salfi, Darna Bhikshapathi & Abdullah Khan. (2022) Anticancer Evaluation of Novel Quinazolinone Acetamides: Synthesis and Characterization. Anti-Cancer Agents in Medicinal Chemistry 22:5, pages 926-932.
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Ahmed Elkamhawy, Jiyu Woo, Hossam Nada, Andrea Angeli, Tarek M. Bedair, Claudiu T. Supuran & Kyeong Lee. (2022) Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies. International Journal of Molecular Sciences 23:5, pages 2540.
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Cauê Benito Scarim & Fernando Rogério Pavan. (2022) An overview of sulfonamide‐based conjugates: Recent advances for tuberculosis treatment. Drug Development Research.
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Anjaly Das, Aparna Das & Bimal Krishna Banik. (2021) Influence of dipole moments on the medicinal activities of diverse organic compounds. Journal of the Indian Chemical Society 98:2, pages 100005.
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Alessio Nocentini, Alane B. Vermelho & Claudiu T. Supuran. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 83 111 .
Claudiu T. Supuran, Anna Di Fiore, Seppo Parkkila & Giuseppina De Simone. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 279 292 .
Clemente Capasso & Claudiu T. Supuran. 2022. Antiprotozoal Drug Development and Delivery. Antiprotozoal Drug Development and Delivery 241 258 .
Cauê B. Scarim, Rafael C. Chelucci, Jean L. dos Santos & Chung M. Chin. (2020) The use of Sulfonamide Derivatives in the Treatment of Trypanosomatid Parasites including Trypanosoma cruzi, Trypanosoma brucei , and Leishmania ssp . Medicinal Chemistry 16:1, pages 24-38.
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Ahmed I. Khodair, Mona A. Elsafi & Siham A. Al‐Issa. (2019) Simple and Efficient Synthesis of Novel 3‐Substituted 2‐Thioxo‐2,3‐dihydro‐1 H ‐benzo[ g ]quinazolin‐4‐ones and Their Reactions with Alkyl Halides and α‐Glycopyranosyl Bromides . Journal of Heterocyclic Chemistry 56:9, pages 2358-2368.
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Alessandro Bonardi, Alane Beatriz Vermelho, Veronica da Silva Cardoso, Mirian Claudia de Souza Pereira, Leonardo da Silva Lara, Silvia Selleri, Paola Gratteri, Claudiu T. Supuran & Alessio Nocentini. (2018) N -Nitrosulfonamides as Carbonic Anhydrase Inhibitors: A Promising Chemotype for Targeting Chagas Disease and Leishmaniasis . ACS Medicinal Chemistry Letters 10:4, pages 413-418.
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Ashok Aspatwar, Harlan Barker, Martti Tolvanen, Reza Zolfaghari Emameh & Seppo Parkkila. 2019. Carbonic Anhydrases. Carbonic Anhydrases 449 475 .
Hatem A. Abuelizz, Mohamed Marzouk, Hazem Ghabbour & Rashad Al-Salahi. (2017) Synthesis and anticancer activity of new quinazoline derivatives. Saudi Pharmaceutical Journal 25:7, pages 1047-1054.
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Sonia Del Prete, Daniela Vullo, Viviana De Luca, Vincenzo Carginale, Pietro di Fonzo, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran & Clemente Capasso. (2016) Anion inhibition profiles of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum. Bioorganic & Medicinal Chemistry 24:18, pages 4410-4414.
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Claudiu T Supuran. (2016) Inhibition of carbonic anhydrase from Trypanosoma cruzi for the management of Chagas disease: an underexplored therapeutic opportunity . Future Medicinal Chemistry 8:3, pages 311-324.
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Claudiu T. Supuran & Clemente Capasso. 2017. Zinc Enzyme Inhibitors. Zinc Enzyme Inhibitors 111 133 .

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