Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 30, Issue 4 (2015)

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Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 30, Issue 4 (2015)

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Original Article

Article
Exploring QSARs of some benzenesulfonamides incorporating cyanoacrylamide moieties as a carbonic anhydrase inhibitors (specifically against tumor-associated isoforms IX and XII)
Ahmed M. Alafeefy, Hatem A. Abdel-Aziz, F. Carta, Claudiu T. Supuran, Shilendra K. Pathak, Onkar Prasad & Leena Sinha
Pages: 519-523
Published online: 08 Sep 2014
AbstractforExploring QSARs of some benzenesulfonamides incorporating cyanoacrylamide moieties as a carbonic anhydrase inhibitors (specifically against tumor-associated isoforms IX and XII) | Full Text | References | PDF (384.2 KB) | Supplemental
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Original Articles

Article
A new affinity method for purification of bovine testicular hyaluronidase enzyme and an investigation of the effects of some compounds on this enzyme
Mustafa Oguzhan Kaya, Oktay Arslan & Ozen Ozensoy Guler
Pages: 524-527
Published online: 06 Nov 2014
AbstractforA new affinity method for purification of bovine testicular hyaluronidase enzyme and an investigation of the effects of some compounds on this enzyme | Full Text | References | PDF (318.7 KB)
  • 1956 Views
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Short Communication

A computational insight into acetylcholinesterase inhibitory activity of a new lichen depsidone
Abdulilah Ece & Boris Pejin
Pages: 528-532
Published online: 08 Sep 2014
AbstractforA computational insight into acetylcholinesterase inhibitory activity of a new lichen depsidone | Full Text | References | PDF (1,021.6 KB)
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Research Article

Article
Effects of prodigiosin family compounds from Pseudoalteromonas sp. 1020R on the activities of protein phosphatases and protein kinases
Azamjon B. Soliev, Kakushi Hosokawa & Keiichi Enomoto
Pages: 533-538
Published online: 06 Nov 2014
AbstractforEffects of prodigiosin family compounds from Pseudoalteromonas sp. 1020R on the activities of protein phosphatases and protein kinases | Full Text | References | PDF (548 KB)
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Original Article

Article
Stability and binding effects of silver(I) complexes at lipoxygenase-1
Eleni Vrontaki, Georgios Leonis, Aggelos Avramopoulos, Manthos G. Papadopoulos, Mihael Simčič, Simona Golič Grdadolnik, Antreas Afantitis, Georgia Melagraki, Sotiris K. Hadjikakou & Thomas Mavromoustakos
Pages: 539-549
Published online: 06 Nov 2014
AbstractforStability and binding effects of silver(I) complexes at lipoxygenase-1 | Full Text | References | PDF (1.8 MB) | Supplemental
  • 1064 Views
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Review Article

Synthesis of the inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors
Grzegorz Cholewiński, Dorota Iwaszkiewicz-Grześ, Michał Prejs, Agnieszka Głowacka & Krystyna Dzierzbicka
Pages: 550-563
Published online: 08 Sep 2014
AbstractforSynthesis of the inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors | Full Text | References | PDF (1.9 MB)
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Original Article

Article
Synthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines
Kaan Kucukoglu, Ebru Mete, Rengul Cetin-Atalay & Halise Inci Gul
Pages: 564-568
Published online: 08 Sep 2014
AbstractforSynthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell lines | Full Text | References | PDF (190.1 KB)
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Research Article

Article
Purification and characterization of a phenoloxidase in the hemocytes of Ephestia kuehniella Zeller (Lepidoptera: Pyralidae): effects of insect growth regulators and endogenous inhibitors
Sahar Delkash-Roudsari, Arash Zibaee & Zargham Bigham
Pages: 569-574
Published online: 06 Nov 2014
AbstractforPurification and characterization of a phenoloxidase in the hemocytes of Ephestia kuehniella Zeller (Lepidoptera: Pyralidae): effects of insect growth regulators and endogenous inhibitors | Full Text | References | PDF (235.5 KB) | Supplemental
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Review Article

Cyclotides: a natural combinatorial peptide library or a bioactive sequence player?
Adriano Mollica, Roberto Costante, Azzurra Stefanucci & Ettore Novellino
Pages: 575-580
Published online: 22 Sep 2014
AbstractforCyclotides: a natural combinatorial peptide library or a bioactive sequence player? | Full Text | References | PDF (881.4 KB)
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Original Articles

Article
A new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase from Trypanosoma cruzi
Ahmed M. Alafeefy, Mariangela Ceruso, Nabila A. Al-Jaber, Seppo Parkkila, Alane Beatriz Vermelho & Claudiu T. Supuran
Pages: 581-585
Published online: 06 Nov 2014
AbstractforA new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase from Trypanosoma cruzi | Full Text | References | PDF (307.1 KB)
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Article
Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII)
Andrea Scozzafava, Maurizio Passaponti, Claudiu T. Supuran & İlhami Gülçin
Pages: 586-591
Published online: 06 Nov 2014
AbstractforCarbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII) | Full Text | References | PDF (292.9 KB)
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Research Article

Article
Inhibition studies of quinazoline-sulfonamide derivatives against the γ-CA (PgiCA) from the pathogenic bacterium, Porphyromonas gingivalis
Ahmed M. Alafeefy, Mariangela Ceruso, Abdul-Malek S. Al-Tamimi, Sonia Del Prete, Claudiu T. Supuran & Clemente Capasso
Pages: 592-596
Published online: 19 Nov 2014
AbstractforInhibition studies of quinazoline-sulfonamide derivatives against the γ-CA (PgiCA) from the pathogenic bacterium, Porphyromonas gingivalis | Full Text | References | PDF (311.1 KB)
  • 684 Views
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Article
Novel pyrazole–pyrazoline hybrids endowed with thioamide as antimalarial agents: their synthesis and 3D-QSAR studies
Akranth Marella, Mohammad Shaquiquzzaman, Mymoona Akhter, Garima Verma & Mohammad Mumtaz Alam
Pages: 597-606
Published online: 21 Oct 2014
AbstractforNovel pyrazole–pyrazoline hybrids endowed with thioamide as antimalarial agents: their synthesis and 3D-QSAR studies | Full Text | References | PDF (694.9 KB) | Supplemental
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Article
Synthesis of quinolinylaminopyrimidines and quinazolinylmethylaminopyrimidines with antiproliferative activity against melanoma cell line
Jun A Lee, Eun Joo Roh, Chang-Hyun Oh, So Ha Lee, Taebo Sim, Jong Seung Kim & Kyung Ho Yoo
Pages: 607-614
Published online: 28 Nov 2014
AbstractforSynthesis of quinolinylaminopyrimidines and quinazolinylmethylaminopyrimidines with antiproliferative activity against melanoma cell line | Full Text | References | PDF (796.1 KB) | Supplemental
  • 766 Views
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Article
Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent
Diogo R. M. Moreira, Matheus S. de Sá, Taís S. Macedo, Maria N. Menezes, José Rui M. Reys, Antônio E. G. Santana, Thaissa L. Silva, Gabriela L. A. Maia, José M. Barbosa-Filho, Celso A. Camara, Tania M. S. da Silva, Katia N. da Silva, Elisalva T. Guimaraes, Ricardo R. dos Santos, Marília O. F. Goulart & Milena B. P. Soares
Pages: 615-621
Published online: 28 Nov 2014
AbstractforEvaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent | Full Text | References | PDF (773 KB)
  • 1139 Views
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Article
Human serum paraoxonase-1 (hPON1): in vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium
Cüneyt Türkeş, Hakan Söyüt & Şükrü Beydemir
Pages: 622-628
Published online: 18 Dec 2014
AbstractforHuman serum paraoxonase-1 (hPON1): in vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium | Full Text | References | PDF (563.1 KB)
  • 1228 Views
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Review Article

Mycobacterium tuberculosis enoyl-acyl carrier protein reductase inhibitors as potential antituberculotics: development in the past decade
Ondrej Holas, Pavel Ondrejcek & Martin Dolezal
Pages: 629-648
Published online: 10 Nov 2014
AbstractforMycobacterium tuberculosis enoyl-acyl carrier protein reductase inhibitors as potential antituberculotics: development in the past decade | Full Text | References | PDF (7.4 MB)
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Research Article

Article
Cytotoxic activities of some benzothiazole-piperazine derivatives
Enise Ece Gurdal, Irem Durmaz, Rengul Cetin-Atalay & Mine Yarim
Pages: 649-654
Published online: 21 Oct 2014
AbstractforCytotoxic activities of some benzothiazole-piperazine derivatives | Full Text | References | PDF (597.2 KB)
  • 1485 Views
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Article
Phosphorylation controls the functioning of Staphylococcus aureus isocitrate dehydrogenase – favours biofilm formation
U. Venkateswara Prasad, D. Vasu, S. Yeswanth, V. Swarupa, M. M. Sunitha, A. Choudhary & P. V. G. K. Sarma
Pages: 655-661
Published online: 06 Mar 2015
AbstractforPhosphorylation controls the functioning of Staphylococcus aureus isocitrate dehydrogenase – favours biofilm formation | Full Text | References | PDF (1.8 MB)
  • 919 Views
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Article
Receptor-based virtual screening evaluation for the identification of estrogen receptor β ligands
Tiziano Tuccinardi, Giulio Poli, Marco Dell'Agnello, Carlotta Granchi, Filippo Minutolo & Adriano Martinelli
Pages: 662-670
Published online: 29 Sep 2014
AbstractforReceptor-based virtual screening evaluation for the identification of estrogen receptor β ligands | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1185 Views
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Article
Preparation, anticholinesterase activity, and docking study of new 2-butenediamide and oxalamide derivatives
Kadir Ozden Yerdelen, Mehmet Koca, Zeynep Kasap & Baris Anil
Pages: 671-678
Published online: 28 Nov 2014
AbstractforPreparation, anticholinesterase activity, and docking study of new 2-butenediamide and oxalamide derivatives | Full Text | References | PDF (1.3 MB) | Supplemental
  • 801 Views
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Article
Antitumor evaluation and molecular docking study of substituted 2-benzylidenebutane-1,3-dione, 2-hydrazonobutane-1,3-dione and trifluoromethyl-1H-pyrazole analogues
Ibrahim A. Al-Suwaidan, Naglaa I. Abdel-Aziz, Adel S. El-Azab, Magda A.-A. El-Sayed, Amer M. Alanazi, Mahmoud B. El-Ashmawy & Alaa A.-M. Abdel-Aziz
Pages: 679-687
Published online: 04 Dec 2014
AbstractforAntitumor evaluation and molecular docking study of substituted 2-benzylidenebutane-1,3-dione, 2-hydrazonobutane-1,3-dione and trifluoromethyl-1H-pyrazole analogues | Full Text | References | PDF (726.8 KB)
  • 1736 Views
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