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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 30, 2015 - Issue 5
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Research Article

Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling

Ahmed MalkiDepartment of Health Sciences, Biomedical Sciences Program, College of Arts and Sciences, Qatar University, Doha, Qatar, ;Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt, Correspondence[email protected]
,
Rasha Y. ElbayaaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt, Correspondence[email protected]
,
Hayam M.A. AshourDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt,
,
Christopher A. LoffredoLombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, DC, USA, and
&
Amal M. YoussefDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt, ;College of Pharmacy, Al Ain University of Science and Technology, Al Ain, United Arab Emirates
Pages 786-795 | Received 24 Aug 2014, Accepted 29 Sep 2014, Published online: 27 Aug 2015

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Barbara Kaproń, Anita Płazińska, Wojciech Płaziński & Tomasz Plech. (2023) Identification of the first-in-class dual inhibitors of human DNA topoisomerase IIα and indoleamine-2,3-dioxygenase 1 (IDO 1) with strong anticancer properties. Journal of Enzyme Inhibition and Medicinal Chemistry 38:1, pages 192-202.
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Ahmed Malki, Hayam M. A. Ashour, Rasha Y. Elbayaa, Doaa A. E. Issa, Hassan A. Aziz & Xiaozhuo Chen. (2016) Novel 1,5-diphenyl-6-substituted 1H-pyrazolo[3,4-d]pyrimidin-4(5H)-ones induced apoptosis in RKO colon cancer cells. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1286-1299.
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Łucja Justyna Walczak-Nowicka, Aleksandra Szopa, Monika Pitucha, Anna Serefko, Anna Pachuta-Stec, Kamil Pawłowski, Monika Gawrońska-Grzywacz, Joanna Lachowicz & Mariola Herbet. (2024) Newly synthesized derivatives with a thiosemicarbazide group reduce the viability of cancer cell lines. Acute toxicity assessment in Zebrafish (Danio rerio) early life stages. Toxicology in Vitro 95, pages 105741.
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Shubham Jaiswal, Lokesh Yadav, Shivendra Kumar Pandey, Suryansh Chandra, M.K. Bharty, L.B. Prasad & A. Acharya. (2023) Synthesis, characterizations, crystal structure and anticancer activity of Mn(II), Co(II) and Ni(II) complexes of N′-cyclohexyl-2-thiophene-carbonyl hydrazine carbothioamide. Polyhedron 238, pages 116408.
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Akhalesh Kumar, Rakhi Mishra, Avijit Mazumder, Rupa Mazumder & Shruti Varshney. (2023) Exploring Synthesis and Chemotherapeutic Potential of Thiosemicarbazide Analogs. Anti-Cancer Agents in Medicinal Chemistry 23:1, pages 60-75.
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Kamal S. Abdelrahman, Heba A. Hassan, Salah A. Abdel-Aziz, Adel A. Marzouk, Atsushi Narumi, Hiroyuki Konno & Mohamed Abdel-Aziz. (2021) JNK signaling as a target for anticancer therapy. Pharmacological Reports 73:2, pages 405-434.
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Stephanie B. Arulnathan, Kok H. Leong, Azhar Ariffin, Huda S. Kareem & Kevin K.H. Cheah. (2020) Activation of Intrinsic Apoptosis and G1 Cell Cycle Arrest by a Triazole Precursor, N-(4-chlorophenyl)-2-(4-(3,4,5-trimethoxybenzyloxy)benzoyl)-hydrazinecarbothioamide in Breast Cancer Cell Line. Anti-Cancer Agents in Medicinal Chemistry 20:9, pages 1072-1086.
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Muafia Jabeen, Muhammad Iqbal Choudhry, Ghulam Abbas Miana, Khondaker Miraz Rahman, Umer Rashid, Hidayat-ullah Khan, Arshia & Abdul Sadiq. (2018) Synthesis, pharmacological evaluation and docking studies of progesterone and testosterone derivatives as anticancer agents. Steroids 136, pages 22-31.
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Pengfei Yuan, Jiean Chen, Jing Zhao & Yong Huang. (2018) Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species. Angewandte Chemie International Edition 57:28, pages 8503-8507.
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Pengfei Yuan, Jiean Chen, Jing Zhao & Yong Huang. (2018) Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species. Angewandte Chemie 130:28, pages 8639-8643.
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Omaima G Shaaban, Heba A Abd El Razik, Shams El-Dine A Shams El-Dine, Fawzia A Ashour, Alaa A El-Tombary, Ola S Afifi & Marwa M Abu-Serie. (2018) Purines and triazolo[4,3-e]purines containing pyrazole moiety as potential anticancer and antioxidant agents. Future Medicinal Chemistry 10:12, pages 1449-1464.
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Subbroto Saha, Kyeongseok Kim, Gwang-Mo Yang, Hye Choi & Ssang-Goo Cho. (2018) Cytokeratin 19 (KRT19) has a Role in the Reprogramming of Cancer Stem Cell-Like Cells to Less Aggressive and More Drug-Sensitive Cells. International Journal of Molecular Sciences 19:5, pages 1423.
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Yogita K. Abhale, Abhijit Shinde, Keshav K. Deshmukh, Laxman Nawale, Dhiman Sarkar & Pravin C. Mhaske. (2017) Synthesis, antitubercular and antimicrobial potential of some new thiazole substituted thiosemicarbazide derivatives. Medicinal Chemistry Research 26:10, pages 2557-2567.
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Ahmed Malki, Mona Mohsen, Hassan Aziz, Ola Rizk, Omima Shaban, Mohamed El-Sayed, Zaki Sherif & Hayam Ashour. (2016) New 3-Cyano-2-Substituted Pyridines Induce Apoptosis in MCF 7 Breast Cancer Cells. Molecules 21:2, pages 230.
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