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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 4
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Synthesis and in vitro pharmacological evaluation of N-[(1-benzyl-1,2,3-triazol-4-yl)methyl]-carboxamides on d-secoestrone scaffolds

Johanna SzabóDepartment of Organic Chemistry, University of Szeged, Szeged, Hungary,
,
Ildikó BacsaDepartment of Organic Chemistry, University of Szeged, Szeged, Hungary,
,
János WölflingDepartment of Organic Chemistry, University of Szeged, Szeged, Hungary,
,
Gyula SchneiderDepartment of Organic Chemistry, University of Szeged, Szeged, Hungary,
,
István ZupkóDepartment of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary,
,
Mónika VargaCereal Research Non-Profit Ltd., Szeged, Hungary,
,
Bianka E. Herman1st Department of Medicine, University of Szeged, Szeged, Hungary, and
,
László KalmárDepartment of Obstetrics and Gynecology, University of Szeged, Szeged, Hungary
,
Mihály Szécsi1st Department of Medicine, University of Szeged, Szeged, Hungary, and
&
Erzsébet MernyákDepartment of Organic Chemistry, University of Szeged, Szeged, Hungary, Correspondence[email protected]
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Pages 574-579 | Received 23 Dec 2014, Accepted 28 Apr 2015, Published online: 11 Sep 2015

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Bianka Edina Herman, Anita Kiss, János Wölfling, Erzsébet Mernyák, Mihály Szécsi & Gyula Schneider. (2019) Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 1271-1286.
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Ildikó Bacsa, Bianka Edina Herman, Rebeka Jójárt, Kevin Stefán Herman, János Wölfling, Gyula Schneider, Mónika Varga, Csaba Tömböly, Tea Lanišnik Rižner, Mihály Szécsi & Erzsébet Mernyák. (2018) Synthesis and structure–activity relationships of 2- and/or 4-halogenated 13- and 13α-estrone derivatives as enzyme inhibitors of estrogen biosynthesis. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1271-1282.
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Bianka Edina Herman, Johanna Szabó, Ildikó Bacsa, János Wölfling, Gyula Schneider, Mónika Bálint, Csaba Hetényi, Erzsébet Mernyák & Mihály Szécsi. (2016) Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 61-69.
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Alexey I. Ilovaisky, Alexander M. Scherbakov, Valentina M. Merkulova, Elena I. Chernoburova, Marina A. Shchetinina, Olga E. Andreeva, Diana I. Salnikova, Igor V. Zavarzin & Alexander O. Terent’ev. (2023) Secosteroid–quinoline hybrids as new anticancer agents. The Journal of Steroid Biochemistry and Molecular Biology 228, pages 106245.
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Alexey I. Ilovaisky, Valentina M. Merkulova, Elena I. Chernoburova, Marina A. Shchetinina, Diana I. Salnikova, Alexander M. Scherbakov, Igor V. Zavarzin & Alexander O. Terent’ev. (2021) Secosteroidal hydrazides: Promising scaffolds for anti-breast cancer agents. The Journal of Steroid Biochemistry and Molecular Biology 214, pages 106000.
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Ágnes Erika Kulmány, Bianka Edina Herman, István Zupkó, Masa Sinreih, Tea Lanišnik Rižner, Marina Savić, Aleksandar Oklješa, Andrea Nikolić, Viktória Nagy, Imre Ocsovszki, Mihály Szécsi & Suzana Jovanović-Šanta. (2021) Heterocyclic androstane and estrane d-ring modified steroids: Microwave-assisted synthesis, steroid-converting enzyme inhibition, apoptosis induction, and effects on genes encoding estrogen inactivating enzymes. The Journal of Steroid Biochemistry and Molecular Biology 214, pages 105997.
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Xiao-Man Fan, Jia-Jia Shen, Yuan-Yuan Xu, Jian Gao & Ye-Wang Zhang. (2021) Metabolic integration of azide functionalized glycan on Escherichia coli cell surface for specific covalent immobilization onto magnetic nanoparticles with click chemistry. Bioresource Technology 324, pages 124689.
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Bianka Edina Herman, János Gardi, János Julesz, Csaba Tömböly, Eszter Szánti-Pintér, Klaudia Fehér, Rita Skoda-Földes & Mihály Szécsi. (2020) Steroidal ferrocenes as potential enzyme inhibitors of the estrogen biosynthesis. Biologia Futura 71:3, pages 249-264.
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Mohamed El-Naggar, Abd El-Galil E. Amr, Ahmed A. Fayed, Elsayed A. Elsayed, Mohamed A. Al-Omar & Mohamed M. Abdalla. (2019) Potent Anti-Ovarian Cancer with Inhibitor Activities on Both Topoisomerase II and V600EBRAF of Synthesized Substituted Estrone Candidates. Molecules 24:11, pages 2054.
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Abd Amr, Mohamed El-Naggar, Mohamed Al-Omar, Elsayed Elsayed & Mohamed Abdalla. (2018) In Vitro and In Vivo Anti-Breast Cancer Activities of Some Synthesized Pyrazolinyl-estran-17-one Candidates. Molecules 23:7, pages 1572.
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Ildikó Bacsa, Csilla Konc, Anna Orosz, Gábor Kecskeméti, Réka Rigó, Csilla Özvegy-Laczka & Erzsébet Mernyák. (2018) Synthesis of Novel C-2- or C-15-Labeled BODIPY—Estrone Conjugates. Molecules 23:4, pages 821.
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Ildikó Bacsa, Rebeka Jójárt, János Wölfling, Gyula Schneider, Bianka Edina Herman, Mihály Szécsi & Erzsébet Mernyák. (2017) Synthesis of novel 13α-estrone derivatives by Sonogashira coupling as potential 17β-HSD1 inhibitors. Beilstein Journal of Organic Chemistry 13, pages 1303-1309.
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Brigitta Bodnár, Erzsébet Mernyák, Johanna Szabó, János Wölfling, Gyula Schneider, István Zupkó, Zoltán Kupihár & Lajos Kovács. (2017) Synthesis and in vitro investigation of potential antiproliferative monosaccharide–d-secoestrone bioconjugates. Bioorganic & Medicinal Chemistry Letters 27:9, pages 1938-1942.
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Brigitta Bodnár, Erzsébet Mernyák, János Wölfling, Gyula Schneider, Bianka Herman, Mihály Szécsi, Izabella Sinka, István Zupkó, Zoltán Kupihár & Lajos Kovács. (2016) Synthesis and Biological Evaluation of Triazolyl 13α-Estrone–Nucleoside Bioconjugates. Molecules 21:9, pages 1212.
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Olivera R. Klisurić, Mihály Szécsi, Evgenija A. Djurendić, Szabó Nikoletta, Bianka Edina Herman, Suzana S. Jovanović Šanta, Sanja V. Dojčinović Vujašković, Andrea R. Nikolić, Ksenija J. Pavlović, Jovana J. Ajduković, Aleksandar M. Oklješa, Edward T. Petri, Vesna V. Kojić, Marija N. Sakač & Katarina M. Penov Gaši. (2015) Structural analysis and biomedical potential of novel salicyloyloxy estrane derivatives synthesized by microwave irradiation. Structural Chemistry 27:3, pages 947-960.
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Johanna Szabó, Nóra Jerkovics, Gyula Schneider, János Wölfling, Noémi Bózsity, Renáta Minorics, István Zupkó & Erzsébet Mernyák. (2016) Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols: The First Potent 13α-d-Secoestrone Derivative. Molecules 21:5, pages 611.
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