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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 4
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Research Article

Cinnoline derivatives as human neutrophil elastase inhibitors

Maria Paola GiovannoniNEUROFARBA, Sezione di Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino, Italy, Correspondence[email protected]
,
Igor A. SchepetkinDepartment of Immunology and Infectious Diseases, Montana State University, Bozeman, MT, USA,
,
Letizia CrocettiNEUROFARBA, Sezione di Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino, Italy,
,
Giovanna CicianiNEUROFARBA, Sezione di Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino, Italy,
,
Agostino CilibrizziDepartment of Chemistry, Imperial College London, South Kensington, London, UK,
,
Gabriella GuerriniNEUROFARBA, Sezione di Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino, Italy,
,
Andrei I. KhlebnikovDepartment of Biotechnology and Organic Chemistry, Tomsk Polytechnic University, Tomsk, Russia, and ;Department of Chemistry, Altai State Technical University, Barnaul, Russia
,
Mark T. QuinnDepartment of Immunology and Infectious Diseases, Montana State University, Bozeman, MT, USA,
&
Claudia VergelliNEUROFARBA, Sezione di Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Sesto Fiorentino, Italy,
show all
Pages 628-639 | Received 11 Mar 2015, Accepted 06 May 2015, Published online: 21 Jul 2015

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L Crocetti, MT Quinn, IA Schepetkin & MP Giovannoni. (2019) A patenting perspective on human neutrophil elastase (HNE) inhibitors (2014-2018) and their therapeutic applications. Expert Opinion on Therapeutic Patents 29:7, pages 555-578.
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Maria Paola Giovannoni, Igor A. Schepetkin, Mark T. Quinn, Niccolò Cantini, Letizia Crocetti, Gabriella Guerrini, Antonella Iacovone, Paola Paoli, Patrizia Rossi, Gianluca Bartolucci, Marta Menicatti & Claudia Vergelli. (2018) Synthesis, biological evaluation, and molecular modelling studies of potent human neutrophil elastase (HNE) inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 33:1, pages 1108-1124.
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Claudia Vergelli, Igor A. Schepetkin, Letizia Crocetti, Antonella Iacovone, Maria Paola Giovannoni, Gabriella Guerrini, Andrei I. Khlebnikov, Samuele Ciattini, Giovanna Ciciani & Mark T. Quinn. (2017) Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 821-831.
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