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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 31, 2016 - Issue 4
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Research Article

Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target

Claudia BeatoDipartimento di Farmacia, Università degli studi di Parma, Parma, Italy,
,
Chiara PecchiniDipartimento di Farmacia, Università degli studi di Parma, Parma, Italy,
,
Chiara CocconcelliDipartimento di Farmacia, Università degli studi di Parma, Parma, Italy,
,
Barbara CampaniniDipartimento di Farmacia, Università degli studi di Parma, Parma, Italy,
,
Marialaura MarchettiDipartimento di Farmacia, Università degli studi di Parma, Parma, Italy,
,
Marco PieroniDipartimento di Farmacia, Università degli studi di Parma, Parma, Italy,
,
Andrea MozzarelliDipartimento di Farmacia, Università degli studi di Parma, Parma, Italy, ;Istituto Nazionale Biostrutture e Biosistemi -- Consorzio Interuniversitario, Roma, Italy, and ;Istituto di Biofisica, CNR, Pisa, Italy
&
Gabriele CostantinoDipartimento di Farmacia, Università degli studi di Parma, Parma, Italy, Correspondence[email protected]
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Pages 645-652 | Received 23 Mar 2015, Accepted 17 Apr 2015, Published online: 02 Jul 2015

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Giannamaria Annunziato, Marco Pieroni, Roberto Benoni, Barbara Campanini, Thelma A. Pertinhez, Chiara Pecchini, Agostino Bruno, Joana Magalhães, Stefano Bettati, Nina Franko, Andrea Mozzarelli & Gabriele Costantino. (2016) Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 78-87.
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Articles from other publishers (11)

Stephany M. Ramos de Dios, Jared L. Hass, Danielle L. Graham, Nivesh Kumar, Aina E. Antony, Martha D. Morton & David B. Berkowitz. (2023) Information-Rich, Dual-Function 13 C/ 2 H-Isotopic Crosstalk NMR Assay for Human Serine Racemase (hSR) Provides a PLP-Enzyme “Partitioning Fingerprint” and Reveals Disparate Chemotypes for hSR Inhibition . Journal of the American Chemical Society 145:5, pages 3158-3174.
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Giulia Murtas, Giorgia Letizia Marcone, Alessio Peracchi, Erika Zangelmi & Loredano Pollegioni. (2021) Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase. International Journal of Molecular Sciences 22:8, pages 4231.
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Komal Rani, Mitali Tyagi, Mohit Mazumder, Akanksha Singh, Annaian Shanmugam, Krishna Dalal, Manoj Pillai, Gourinath Samudrala, Saroj Kumar & Alagiri Srinivasan. (2020) Accelerated identification of serine racemase inhibitor from Centella asiatica. Scientific Reports 10:1.
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Chloe R. Koulouris, Benjamin D. Bax, John R. Atack & S. Mark Roe. (2020) Conformational flexibility within the small domain of human serine racemase. Acta Crystallographica Section F Structural Biology Communications 76:2, pages 65-73.
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Jean‐Pierre Mothet, Jean‐Marie Billard, Loredano Pollegioni, Joseph T. Coyle & Jonathan V. Sweedler. (2019) Investigating brain d ‐serine: Advocacy for good practices . Acta Physiologica 226:1, pages e13257.
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Samanta Raboni, Marialaura Marchetti, Serena Faggiano, Barbara Campanini, Stefano Bruno, Francesco Marchesani, Marilena Margiotta & Andrea Mozzarelli. (2019) The Energy Landscape of Human Serine Racemase. Frontiers in Molecular Biosciences 5.
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Loredano Pollegioni, Silvia Sacchi & Giulia Murtas. (2018) Human D-Amino Acid Oxidase: Structure, Function, and Regulation. Frontiers in Molecular Biosciences 5.
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Satoyuki Takahara, Kiyomi Nakagawa, Tsugumi Uchiyama, Tomoyuki Yoshida, Kazunori Matsumoto, Yasuo Kawasumi, Mineyuki Mizuguchi, Takayuki Obita, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Hisashi Mori & Naoki Toyooka. (2018) Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase. Bioorganic & Medicinal Chemistry Letters 28:3, pages 441-445.
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Stefano Bruno, Francesco Marchesani, Luca Dellafiora, Marilena Margiotta, Serena Faggiano, Barbara Campanini & Andrea Mozzarelli. (2016) Human serine racemase is allosterically modulated by NADH and reduced nicotinamide derivatives. Biochemical Journal 473:20, pages 3505-3516.
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Marco Pieroni, Giannamaria Annunziato, Claudia Beato, Randy Wouters, Roberto Benoni, Barbara Campanini, Thelma A. Pertinhez, Stefano Bettati, Andrea Mozzarelli & Gabriele Costantino. (2016) Rational Design, Synthesis, and Preliminary Structure–Activity Relationships of α-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O -Acetylserine Sulfhydrylase . Journal of Medicinal Chemistry 59:6, pages 2567-2578.
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Song Cao, Zhi Xiao, Mengjie Sun & Youyan Li. (2016) D-serine in the midbrain periaqueductal gray contributes to morphine tolerance in rats. Molecular Pain 12, pages 174480691664678.
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