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Research Article

The Mechanism of Inhibition of S-Adenosyl-L-Homocysteine Hydrolase by Fluorine-Containing Adenosine Analogs

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Pages 1-13 | Received 05 Sep 1989, Published online: 27 Sep 2008

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Read on this site (6)

Chong-Sheng Yuan, Yoshihisa Saso, Elias Lazarides, Ronald T Borchardt & Morris J Robins. (1999) Recent advances in S-adenosyl-L-homocysteine hydrolase inhibitors and their potential clinical applications. Expert Opinion on Therapeutic Patents 9:9, pages 1197-1206.
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M. Muzard, C. Vandenplas, D. Guillerm & G. Guillerm. (1998) The Mechanism of Inactivation of S-Adenosylhomocysteine Hydrolase by Fluorinated Analogs of 5′-Methylthio Adenosine. Journal of Enzyme Inhibition 13:6, pages 443-456.
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DavidR. Borcherding, BrentT. Butler, MatthewD. Linnik, Shujaath Mehdi, MarkW. Dudley & CarlK. Edwards$suffix/text()$suffix/text(). (1996) Cis (IS,3R)-1-(9-Adenyl)-3-Hydroxycyclopentane Inhibits the Respiratory Burst from Polymorphonuclear Leukocytes and Has In Vivo Efficacy in an Acute and Chronic Model of Inflammation. Nucleosides and Nucleotides 15:5, pages 967-979.
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Chong-Sheng Yuan, Siming Liu, StanislawF. Wnuk, MomsJ. Robins & RonaldT. Borchardt. (1995) Rational Approaches to the Design of Mechanism-Based Inhibitors of S-Adenosylhomocysteine Hydrolase. Nucleosides and Nucleotides 14:3-5, pages 439-447.
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MorrisJ. Robins & StanislawF. Wnuk. (1994) Selected Aspects of the Chemistry and Biochemistry of Sulfur-Containing Nucleosides. Phosphorus, Sulfur, and Silicon and the Related Elements 95:1-4, pages 71-88.
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Articles from other publishers (13)

Benjamin M. Johnson, Yue-Zhong Shu, Xiaoliang Zhuo & Nicholas A. Meanwell. (2020) Metabolic and Pharmaceutical Aspects of Fluorinated Compounds. Journal of Medicinal Chemistry 63:12, pages 6315-6386.
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Lipirani Jana, Pikash Pratim Maity, Hasina Perveen, Moumita Dash, Suryashis Jana, Arindam Dey, Subrata Kumar De & Sandip Chattopadhyay. (2018) Attenuation of utero-toxicity, metabolic dysfunction and inflammation by soy protein concentrate in rats exposed to fluoridated water: consequence of hyperlipidemia in parallel with hypohomocysteinemia. Environmental Science and Pollution Research 25:36, pages 36462-36473.
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Shujaath Mehdi. 2013. Enzyme Technologies. Enzyme Technologies 81 129 .
Jennifer A Steere & John F Honek. (2003) Synthesis and biological activity of novel S-Adenosyl-l-homocysteine hydrolase inhibitors. Bioorganic & Medicinal Chemistry 11:15, pages 3229-3236.
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Jennifer A Steere, Peter B Sampson & John F Honek. (2002) Synthesis of an α-Aminophosphonate Nucleoside as an Inhibitor of S-Adenosyl-l-Homocysteine Hydrolase. Bioorganic & Medicinal Chemistry Letters 12:3, pages 457-460.
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Sharon Rounds, Winnie Lin Yee, Doloretta D. Dawicki, Elizabeth Harrington, Nancy Parks & Michael V. Cutaia. (1998) Mechanism of extracellular ATP- and adenosine-induced apoptosis of cultured pulmonary artery endothelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 275:2, pages L379-L388.
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A. A. Ozerov & M. S. Novikov. (1996) Synthesis of unsaturated adenine derivatives, potential inhibitors of S-adenosyl-L-homocysteine hydrolase. Chemistry of Heterocyclic Compounds 32:6, pages 712-715.
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Chong-Sheng Yuan, Siming Liu, Stanislaw F. Wnuk, Morris J. Robins & Ronald T. Borchardt. 1996. 41 88 .
Donald P. Matthews, Michael L. Edwards, Shujaath Mehdi, Jack R. Koehl, Jeffrey A. Wolos & James R. McCarthy. (1993) (E) and (Z)5′-fluoro olefin carbocyclic nucleosides: effect of olefin geometry on inhibition of s-adenosyl-l-homocysteine hydrolase. Bioorganic & Medicinal Chemistry Letters 3:2, pages 165-168.
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Stanislaw F. Wnuk. (1993) Sulfur- and seleno-sugar modified nucleosides. Synthesis, chemical transformations and biological properties.. Tetrahedron 49:44, pages 9877-9936.
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Morris J. Robins, Stanislaw F. Wnuk, Khairuzzaman B. Mullah, N. Kent Dalley, Ronald T. Borchardt, Younha Lee & Chong-Sheng Yuan. 1993. Nucleosides and Nucleotides as Antitumor and Antiviral Agents. Nucleosides and Nucleotides as Antitumor and Antiviral Agents 115 126 .
Siming Liu, Michael S. Wolfe, Chongsheng Yuan, Syed Mashhood Ali & Ronald T. Borchardt. (1992) Synthesis and evaluation of 4′-5′-dehydro-5′-fluoroaristeromycins as S-adenosyl-L-homocysteine (AdoHcy) hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters 2:12, pages 1741-1744.
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Siming Liu, Michael S. Wolfe & Ronald T. Borchardt. (1992) Rational approaches to the design of antiviral agents based on S-adenosyl-l-homocysteine hydrolase as a molecular target. Antiviral Research 19:3, pages 247-265.
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