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Caffeine impact on neonatal morbidities

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Pages 20-23 | Received 16 Aug 2010, Published online: 27 Sep 2010

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Yiqun Miao, Wenwen Liu, Shuliang Zhao, Yanan Li, Huimin Jiang, Aihua Wang, Ping Teng & Yuanyuan Zhang. (2023) Effect of prophylactic caffeine in the treatment of apnea in very low birth weight infants: a meta-analysis. The Journal of Maternal-Fetal & Neonatal Medicine 36:1.
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João Monteiro, Marco G. Alves, Pedro F. Oliveira & Branca M. Silva. (2019) Pharmacological potential of methylxanthines: Retrospective analysis and future expectations. Critical Reviews in Food Science and Nutrition 59:16, pages 2597-2625.
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Mohamed A. Abdel Wahed, Hanan M. Issa, Soha M. Khafagy & Shaimaa M. Abdel Raouf. (2019) Effect of caffeine on superior mesenteric artery blood flow velocities in preterm neonates. The Journal of Maternal-Fetal & Neonatal Medicine 32:3, pages 357-361.
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S. Picone, M. Bedetta & P. Paolillo. (2012) Caffeine citrate: when and for how long. A literature review. The Journal of Maternal-Fetal & Neonatal Medicine 25:sup3, pages 11-14.
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Articles from other publishers (55)

Zheng Xie & Aaron P. Fox. (2023) Rapid emergence from dexmedetomidine sedation in Sprague Dawley rats by repurposing an α2-adrenergic receptor competitive antagonist in combination with caffeine. BMC Anesthesiology 23:1.
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Negar Sajjadian, Peymaneh Alizadeh Taheri & Mahboobeh Jabbari. (2022) Is Early Preventive Caffeine Safe and Effective in Premature Neonates? A Clinical Trial. International Journal of Pediatrics 2022, pages 1-8.
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Yi-Chieh Lin, Yin-Ling Tan, Ting-An Yen, Chien-Yi Chen, Po-Nien Tsao & Hung-Chieh Chou. (2022) Specific Premature Groups Have Better Benefits When Treating Apnea With Caffeine Than Aminophylline/Theophylline. Frontiers in Pediatrics 10.
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Vivien Yap & Jeffrey M. Perlman. 2022. Goldsmith's Assisted Ventilation of the Neonate. Goldsmith's Assisted Ventilation of the Neonate 532 540.e4 .
Vanessa P. Gaspar, Sahar Ibrahim, René P. Zahedi & Christoph H. Borchers. (2021) Utility, promise, and limitations of liquid chromatography‐mass spectrometry‐based therapeutic drug monitoring in precision medicine. Journal of Mass Spectrometry 56:11.
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Jia-Yi Long, Hong-Li Guo, Xin He, Ya-Hui Hu, Ying Xia, Rui Cheng, Xuan-Sheng Ding, Feng Chen & Jing Xu. (2021) Caffeine for the Pharmacological Treatment of Apnea of Prematurity in the NICU: Dose Selection Conundrum, Therapeutic Drug Monitoring and Genetic Factors. Frontiers in Pharmacology 12.
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Alyce M. Swinbourne, Karen L. Kind, Tom Flinn, David O. Kleemann & William H.E.J. van Wettere. (2021) Caffeine: A potential strategy to improve survival of neonatal pigs and sheep. Animal Reproduction Science 226, pages 106700.
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Jacob V. Aranda & Kay D. Beharry. (2020) Pharmacokinetics, pharmacodynamics and metabolism of caffeine in newborns. Seminars in Fetal and Neonatal Medicine 25:6, pages 101183.
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Chen Kou, Dong Han, Zhaona Li, Wei Wu, Zunjie Liu, Yanan Zhang & Zhengping Gao. (2020) Influence of prevention of caffeine citrate on cytokine profile and bronchopulmonary dysplasia in preterm infants with apnea. Minerva Pediatrica 72:2.
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Laura Moschino, Sanja Zivanovic, Caroline Hartley, Daniele Trevisanuto, Eugenio Baraldi & Charles Christoph Roehr. (2020) Caffeine in preterm infants: where are we in 2020?. ERJ Open Research 6:1, pages 00330-2019.
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Guanghui Chen, Qi Zhang, Can Ai, Songqiang Huang, Huizhen Zhang, Xiaoyu Guo, Wenju Wang, Weiying Hua, Huichang Bi & Hui Wang. (2019) Serum metabolic profile characteristics of offspring rats before and after birth caused by prenatal caffeine exposure. Toxicology 427, pages 152302.
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Mihai Puia-Dumitrescu, P. Brian Smith, Jian Zhao, Angela Soriano, Elizabeth H. Payne, Barrie Harper, Ellen Bendel-Stenzel, Fernando Moya, Rakesh Chhabra, Lawrence Ku, Matthew Laughon, Kelly C. Wade, Gary Furda, Danny Benjamin, Edmund Capparelli, Gregory L. Kearns, Ian M. Paul & Christoph Hornik. (2019) Dosing and Safety of Off-label Use of Caffeine Citrate in Premature Infants. The Journal of Pediatrics 211, pages 27-32.e1.
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Saranya Ravichandran, Nitin Shashikant Chouthai, Bhavyata Patel, Amit Sharma, Avanti Gupte, Mia Michelle Ma, Divya Mamilla, Mirjana Lulic‐Botica, Ronald Thomas & Deepak Kamat. (2018) Higher daily doses of caffeine lowered the incidence of moderate to severe neurodevelopmental disabilities in very low birth weight infants. Acta Paediatrica 108:3, pages 430-435.
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Julie T. Millard, Tenzin Passang, Jiayu Ye, Gabriel M. Kline, Tina M. Beachy, Victoria L. Hepburn & Edmund J. Klinkerch. (2018) Genotype and Phenotype of Caffeine Metabolism: A Biochemistry Laboratory Experiment. Journal of Chemical Education 95:10, pages 1856-1860.
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Stefanie Endesfelder, Ulrike Weichelt, Cornelia Schiller, Katja Winter, Clarissa von Haefen & Christoph Bührer. (2018) Caffeine Protects Against Anticonvulsant-Induced Impaired Neurogenesis in the Developing Rat Brain. Neurotoxicity Research 34:2, pages 173-187.
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A. Lodha, Y. Rabi, A. Soraisham, J. Dobry, Arijit Lodha, H. Amin, E. Al Awad, S. Tang, A. Sahai & V. Bhandari. (2018) Does duration of caffeine therapy in preterm infants born ≤1250 g at birth influence neurodevelopmental (ND) outcomes at 3 years of age?. Journal of Perinatology 38:7, pages 889-899.
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John Evered, Eric Pfeifer & Matthew Gracianette. (2018) Caffeine to prevent respiratory failure and improve outcome in infant pertussis. BMJ Case Reports, pages bcr-2017-223102.
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Kevin K. Noguchi, Stephen A. Johnson, Francesca M. Manzella, Kobe L. Masuoka, Sasha L. Williams, Lauren D. Martin, Gregory A. Dissen, Chrysanthy Ikonomidou, Katie J. Schenning, John W. Olney & Ansgar M. Brambrink. (2018) Caffeine Augments Anesthesia Neurotoxicity in the Fetal Macaque Brain. Scientific Reports 8:1.
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Funmilayo Eniola OlopadeMatthew Temitayo Shokunbi. (2018) The Development of the External Granular Layer of the Cerebellum and Neurobehavioral Correlates in Neonatal Rats Following Intrauterine and Postnatal Exposure to Caffeine. Journal of Caffeine and Adenosine Research 8:1, pages 27-36.
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Funmilayo Eniola OlopadeMatthew Temitayo Shokunbi. (2017) The Development of the External Granular Layer of the Cerebellum and Neurobehavioral Correlates in Neonatal Rats Following Intrauterine and Postnatal Exposure to Caffeine. Journal of Caffeine Research.
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Chuan-Fa Tang, Dewei Wang & Joshua M. Tebbs. (2017) Nonparametric goodness-of-fit tests for uniform stochastic ordering. The Annals of Statistics 45:6.
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Bikash Shrestha & Gaurav Jawa. (2017) Caffeine citrate – Is it a silver bullet in neonatology?. Pediatrics & Neonatology 58:5, pages 391-397.
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Stefanie Endesfelder, Ulrike Weichelt, Cornelia Schiller, Marco Sifringer, Ivo Bendix & Christoph Bührer. (2017) Caffeine Protects Against Anticonvulsant-Induced Neurotoxicity in the Developing Rat Brain. Neurotoxicity Research 32:3, pages 460-472.
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Xigang Jing, Yi-Wen Huang, Jason Jarzembowski, Yang Shi, Girija G Konduri & Ru-Jeng Teng. (2017) Caffeine ameliorates hyperoxia-induced lung injury by protecting GCH1 function in neonatal rat pups. Pediatric Research 82:3, pages 483-489.
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Prerna Chaudhary, Amitabh Singh, Rahul Jain & Anirban Mandal. (2017) Recurrent Apnea Following Occipital Encephalocele Surgery in A Child -Responding to Caffeine Citrate. Journal of Comprehensive Pediatrics In Press:In Press.
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Matthew A. Rainaldi & Jeffrey M. Perlman. 2017. Assisted Ventilation of the Neonate. Assisted Ventilation of the Neonate 451 458.e2 .
Zhexiao Jiao, Hao Kou, Dan Xu, Hanwen Luo & Hui Wang. 2017. Diet, Nutrition, and Fetal Programming. Diet, Nutrition, and Fetal Programming 339 353 .
Matthias C. Hütten, Tim G. A. M. Wolfs & Boris W. Kramer. (2016) Can the preterm lung recover from perinatal stress?. Molecular and Cellular Pediatrics 3:1.
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Jacob V. Aranda, Charles L. Cai, Taimur Ahmad, Vadim Bronshtein, Jonathan Sadeh, Gloria B. Valencia, Douglas R. Lazzaro & Kay D. Beharry. (2016) Pharmacologic synergism of ocular ketorolac and systemic caffeine citrate in rat oxygen-induced retinopathy. Pediatric Research 80:4, pages 554-565.
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Matteo Bruschettini, Sebastiano Barco, Olga Romantsik, Francesco Risso, Iulian Gennai, Benito Chinea, Luca A Ramenghi, Gino Tripodi & Giuliana Cangemi. (2016) DBS–LC–MS/MS assay for caffeine: validation and neonatal application. Bioanalysis 8:18, pages 1893-1902.
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João Monteiro, Marco Alves, Pedro Oliveira & Branca Silva. (2016) Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks. Molecules 21:8, pages 974.
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J. Bryan Carmody, Matthew W. Harer, Anna R. Denotti, Jonathan R. Swanson & Jennifer R. Charlton. (2016) Caffeine Exposure and Risk of Acute Kidney Injury in a Retrospective Cohort of Very Low Birth Weight Neonates. The Journal of Pediatrics 172, pages 63-68.e1.
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Kay D. Beharry, Gloria B. Valencia, Douglas R. Lazzaro & Jacob V. Aranda. (2016) Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity. Seminars in Perinatology 40:3, pages 189-202.
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Ainhoa Oñatibia-Astibia, Eva Martínez-Pinilla & Rafael Franco. (2016) The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. Respiratory Medicine 112, pages 1-9.
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J Doyle, D Davidson, S Katz, M Varela, D Demeglio & J DeCristofaro. (2015) Apnea of prematurity and caffeine pharmacokinetics: potential impact on hospital discharge. Journal of Perinatology 36:2, pages 141-144.
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Vasiliki I. Hatzi, Maria Karakosta, Katarzyna Barszczewska, Ioanna Karachristou, Gabriel Pantelias & Georgia I. Terzoudi. (2015) Low concentrations of caffeine induce asymmetric cell division as observed in vitro by means of the CBMN-assay and iFISH. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 793, pages 71-78.
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Christopher Welsh, Jingyi Pan & Jaques Belik. (2015) Caffeine impairs gastrointestinal function in newborn rats. Pediatric Research 78:1, pages 24-28.
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S. Carrera Muiños, V. Santillán Briceño, G. Cordero González, E. Yllescas Medrano, L. Fernández Carrocera, P.I. Barrera Martínez & E. Corral Kassian. (2015) Citrato de cafeína: ¿por qué usarlo en los recién nacidos?. Perinatología y Reproducción Humana 29:3, pages 106-112.
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P Alur, V Bollampalli, T Bell, N Hussain & J Liss. (2014) Serum caffeine concentrations and short-term outcomes in premature infants of ⩽29 weeks of gestation. Journal of Perinatology 35:6, pages 434-438.
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Anjali Iyengar & Jonathan M. Davis. (2015) Drug therapy for the prevention and treatment of bronchopulmonary dysplasia. Frontiers in Pharmacology 6.
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Kumi JeongHo Sung KimEun Song SongYoung Youn Choi. (2015) Comparison between Caffeine and Theophylline Therapy for Apnea of Prematurity. Neonatal Medicine 22:1, pages 14.
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Hye Won Park, Gina Lim, Sung-Hoon Chung, Sochung Chung, Kyo Sun Kim & Soo-Nyung Kim. (2015) Early Caffeine Use in Very Low Birth Weight Infants and Neonatal Outcomes: A Systematic Review and Meta-Analysis. Journal of Korean Medical Science 30:12, pages 1828.
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Özge A. Köroğlu, Peter M. MacFarlane, Kannan V. Balan, Woineshet J. Zenebe, Anjum Jafri, Richard J. Martin & Prabha Kc. (2014) Anti-Inflammatory Effect of Caffeine Is Associated with Improved Lung Function after Lipopolysaccharide-Induced Amnionitis. Neonatology 106:3, pages 235-240.
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Markus FehrholzMatthias Hütten, Boris W. Kramer, Christian P. SpeerSteffen Kunzmann. (2014) Amplification of steroid-mediated SP-B expression by physiological levels of caffeine. American Journal of Physiology-Lung Cellular and Molecular Physiology 306:1, pages L101-L109.
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Nicole R. DobsonCarl E. Hunt. (2013) Pharmacology Review: Caffeine Use in Neonates: Indications, Pharmacokinetics, Clinical Effects, Outcomes. NeoReviews 14:11, pages e540-e550.
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Rafael Franco, Ainhoa Oñatibia-Astibia & Eva Martínez-Pinilla. (2013) Health Benefits of Methylxanthines in Cacao and Chocolate. Nutrients 5:10, pages 4159-4173.
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Paola Superchi, Claudio Mazzoni, Paola Zanardelli, Chiara Piancastelli, Ernesto Mario Zambini, Valentino Beretti & Alberto Sabbioni. (2013) Effects of oral caffeine administration to sows with induced parturition on hypoxia in piglets. Livestock Science 157:1, pages 372-377.
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Carla Yuede, John Olney & Catherine Creeley. (2013) Developmental Neurotoxicity of Alcohol and Anesthetic Drugs Is Augmented by Co-Exposure to Caffeine. Brain Sciences 3:4, pages 1128-1152.
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Nadia BoudaaNathalie SamsonVincent CarrièrePamela Samanta GermimJean-Charles Pasquier, Aida Bairam & Jean-Paul Praud. (2013) Effects of caffeine and/or nasal CPAP treatment on laryngeal chemoreflexes in preterm lambs. Journal of Applied Physiology 114:5, pages 637-646.
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Kevin J. Cummings, Kathryn G. Commons, Felicia L. Trachtenberg, Aihua Li, Hannah C. Kinney & Eugene E. Nattie. (2012) Caffeine improves the ability of serotonin-deficient (Pet-1−/−) mice to survive episodic asphyxia. Pediatric Research 73:1, pages 38-45.
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Alan R. Spitzer. (2012) Evidence-Based Methylxanthine Use in the NICU. Clinics in Perinatology 39:1, pages 137-148.
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Reginald P. Sequeira. 2012. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 1 16 .
Alan R. Spitzer. 2012. Manual of Neonatal Respiratory Care. Manual of Neonatal Respiratory Care 593 608 .
Jing Zhao, Fernando Gonzalez & Dezhi Mu. (2011) Apnea of prematurity: from cause to treatment. European Journal of Pediatrics 170:9, pages 1097-1105.
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