1,465
Views
56
CrossRef citations to date
0
Altmetric
Original Article

The relationship between the intensity of intra-amniotic inflammation and the presence and severity of acute histologic chorioamnionitis in preterm gestation

, , , , &
Pages 1500-1509 | Received 15 Aug 2014, Accepted 30 Aug 2014, Published online: 20 Oct 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

Sun Min Kim, Roberto Romero, JoonHo Lee, Piya Chaemsaithong, Min-Woo Lee, Noppadol Chaiyasit, Hyo-Jin Lee & Bo Hyun Yoon. (2023) About one-half of early spontaneous preterm deliveries can be identified by a rapid matrix metalloproteinase-8 (MMP-8) bedside test at the time of mid-trimester genetic amniocentesis*. The Journal of Maternal-Fetal & Neonatal Medicine 29:15, pages 2414-2422.
Read now
Sunil Jaiman, Roberto Romero, Francesca Gotsch, Swarnalata Gowrishankar, Kashif Mohiuddin, Dahiana M. Gallo, Eunjung Jung, Manaphat Suksai & Evita Fernandez. (2022) Fetal sepsis: a cause of stillbirth. The Journal of Maternal-Fetal & Neonatal Medicine 35:25, pages 9966-9970.
Read now
Ji-Hee Sung, Suk-Joo Choi, Soo-young Oh & Cheong-Rae Roh. (2021) Should the diagnostic criteria for suspected clinical chorioamnionitis be changed?. The Journal of Maternal-Fetal & Neonatal Medicine 34:5, pages 824-833.
Read now
Kyung Joon Oh, Joon-Seok Hong, Roberto Romero & Bo Hyun Yoon. (2019) The frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes. The Journal of Maternal-Fetal & Neonatal Medicine 32:4, pages 527-541.
Read now
Piya Chaemsaithong, Roberto Romero, Nikolina Docheva, Noppadol Chaiyasit, Gaurav Bhatti, Percy Pacora, Sonia S. Hassan, Lami Yeo & Offer Erez. (2018) Comparison of rapid MMP-8 and interleukin-6 point-of-care tests to identify intra-amniotic inflammation/infection and impending preterm delivery in patients with preterm labor and intact membranes. The Journal of Maternal-Fetal & Neonatal Medicine 31:2, pages 228-244.
Read now
Gloria Mercedes Galán Henríquez & Fermín García-Muñoz Rodrigo. (2017) Chorioamnionitis and neonatal morbidity: current perspectives. Research and Reports in Neonatology 7, pages 41-52.
Read now
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Ondrej Soucek, Lenka Pliskova, Martin Stepan, Tomas Bestvina, Jan Maly, Bo Jacobsson & Marian Kacerovsky. (2017) Amniotic fluid cathepsin-G in pregnancies complicated by the preterm prelabor rupture of membranes. The Journal of Maternal-Fetal & Neonatal Medicine 30:17, pages 2097-2104.
Read now
Sun Min Kim, Roberto Romero, JoonHo Lee, Piya Chaemsaithong, Nikolina Docheva & Bo Hyun Yoon. (2016) Gastric fluid versus amniotic fluid analysis for the identification of intra-amniotic infection due to Ureaplasma species. The Journal of Maternal-Fetal & Neonatal Medicine 29:16, pages 2579-2587.
Read now
JoonHo Lee, Roberto Romero, Sun Min Kim, Piya Chaemsaithong, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun & Bo Hyun Yoon. (2016) A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. The Journal of Maternal-Fetal & Neonatal Medicine 29:5, pages 707-720.
Read now
Piya Chaemsaithong, Roberto Romero, Steven J. Korzeniewski, Alicia Martinez-Varea, Zhong Dong, Bo Hyun Yoon, Sonia S. Hassan, Tinnakorn Chaiworapongsa & Lami Yeo. (2016) A point of care test for interleukin-6 in amniotic fluid in preterm prelabor rupture of membranes: a step toward the early treatment of acute intra-amniotic inflammation/infection. The Journal of Maternal-Fetal & Neonatal Medicine 29:3, pages 360-367.
Read now
Piya Chaemsaithong, Roberto Romero, Steven J. Korzeniewski, Alicia Martinez-Varea, Zhong Dong, Bo Hyun Yoon, Sonia S. Hassan, Tinnakorn Chaiworapongsa & Lami Yeo. (2016) A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes. The Journal of Maternal-Fetal & Neonatal Medicine 29:3, pages 349-359.
Read now

Articles from other publishers (45)

Sean W. D. Carter, Samantha Neubronner, Lin Lin Su, Pradip Dashraath, Citra Mattar, Sebastián E. Illanes, Mahesh A. Choolani & Matthew W. Kemp. (2023) Chorioamnionitis: An Update on Diagnostic Evaluation. Biomedicines 11:11, pages 2922.
Crossref
Kyo Hoon Park, Kyong‐No Lee, Eun Mi Im, Iseop Cho, Eunji Oh & Bo Young Choi. (2023) Degree of expression of inflammatory proteins in the amniotic cavity, but not prior obstetric history, is associated with the risk severity for spontaneous preterm birth after rescue cerclage for cervical insufficiency. American Journal of Reproductive Immunology 90:3.
Crossref
Jose Galaz, Kenichiro Motomura, Roberto Romero, Zhenjie Liu, Valeria Garcia-Flores, Li Tao, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Tomi Kanninen, Marcelo Farias-Jofre, Derek Miller, Adi L. Tarca & Nardhy Gomez-Lopez. (2023) A key role for NLRP3 signaling in preterm labor and birth driven by the alarmin S100B. Translational Research 259, pages 46-61.
Crossref
Hee Jeung Lim, Jiyu Sun, Banhyang Min, Myungeun Song, Tae Hun Kim, Byoung Jae Kim, Kyu Ri Hwang, Taek Sang Lee, Hye Won Jeon & Sun Min Kim. (2023) Endometriosis and Adverse Pregnancy Outcomes: A Nationwide Population-Based Study. Journal of Clinical Medicine 12:16, pages 5392.
Crossref
Ananth Kumar Kammala, Angela Mosebarger, Enkhtuya Radnaa, Emma Rowlinson, Natasha Vora, Stephen J. Fortunato, Surendra Sharma, Melody Safarzadeh & Ramkumar Menon. (2023) Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response. Frontiers in Immunology 14.
Crossref
Sébastien Molière, Amélie Jaulin, Catherine-Laure Tomasetto & Nassim Dali-Youcef. (2023) Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Metabolism: Insights into Health and Disease. International Journal of Molecular Sciences 24:13, pages 10649.
Crossref
Kanako Gondo, Fumio Yamasaki, Makoto Nomiyama, Nami Hisamoto, Natsumi Yamashita, Takuya Nakagawa, Masazumi Ikeda, Satoko Tsuda, Masato Ishimatsu, Yuko Oshima, Takeshi Ono, Yutaka Kozuma, Yukiko Nakura, Itaru Yanagihara & Keisuke Tsumura. (2023) Relationship of maternal inflammatory response and fetal inflammatory response to duration and intensity of intra-amniotic infection and inflammation. Placenta 137, pages 23-30.
Crossref
Raymond W. Redline, Drucilla J. Roberts, Mana M. Parast, Linda M. Ernst, Terry K. Morgan, Michael F. Greene, Cynthia Gyamfi-Bannerman, Judette M. Louis, Emin Maltepe, Karen K. Mestan, Roberto Romero & Joanne Stone. (2023) Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease. American Journal of Obstetrics and Gynecology 228:2, pages 187-202.
Crossref
Kyong‐No Lee, Iseop Cho, Eun Mi Im, Eunji Oh & Kyo Hoon Park. (2022) Plasma IGFBP‐1, Fas, kallistatin, and P‐selectin as predictive biomarkers of histologic chorioamnionitis and associated intra‐amniotic infection in women with preterm labor. American Journal of Reproductive Immunology 89:1.
Crossref
Lynsa M. Nguyen, David M. Aronoff & Alison J. Eastman. (2022) Matrix metalloproteinases in preterm prelabor rupture of membranes in the setting of chorioamnionitis: A scoping review. American Journal of Reproductive Immunology 89:1.
Crossref
Valeria Garcia-Flores, Roberto Romero, Azam Peyvandipour, Jose Galaz, Errile Pusod, Bogdan Panaitescu, Derek Miller, Yi Xu, Li Tao, Zhenjie Liu, Adi L. Tarca, Roger Pique-Regi & Nardhy Gomez-Lopez. (2023) A single-cell atlas of murine reproductive tissues during preterm labor. Cell Reports 42:1, pages 111846.
Crossref
Kyung Joon Oh, Roberto Romero, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch, Manaphat Suksai & Bo Hyun Yoon. (2022) The role of intraamniotic inflammation in threatened midtrimester miscarriage. American Journal of Obstetrics and Gynecology 227:6, pages 895.e1-895.e13.
Crossref
Danielle Kozlosky, Emily Barrett & Lauren M. Aleksunes. (2022) Regulation of Placental Efflux Transporters during Pregnancy Complications. Drug Metabolism and Disposition 50:10, pages 1364-1375.
Crossref
Il-Yeo Jang, Hye-Ji Jung, Ji-Hee Sung, Suk-Joo Choi, Soo-Young Oh, Jung-Sun Kim & Cheong-Rae Roh. (2022) Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?. Diagnostics 12:9, pages 2126.
Crossref
Seung Mi Lee, Kyo Hoon Park, Eunwook Joo, Da Eun Jeong, Ji Eun Lee, Kyong‐No Lee & Sue Shin. (2022) High‐throughput analysis of amniotic fluid proteins associated with histological chorioamnionitis in preterm premature rupture of membranes using an antibody‐based microarray. American Journal of Reproductive Immunology 88:3.
Crossref
Iseop Cho, Kyong‐No Lee, Eunwook Joo, Yu Mi Kim, Tae Eun Kim & Kyo Hoon Park. (2022) Plasma E‐selectin and kallistatin as predictive markers of histologic chorioamnionitis in women with preterm premature rupture of membranes. American Journal of Reproductive Immunology 88:3.
Crossref
Stefania Ronzoni, Teresa Cobo, Rohan D’Souza, Elizabeth Asztalos, Susan E. O’Rinn, Xingshan Cao, Ana Herranz, Nir Melamed, Silvia Ferrero, Jon Barrett, Victoria Aldecoa & Montse Palacio. (2022) Individualized treatment of preterm premature rupture of membranes to prolong the latency period, reduce the rate of preterm birth, and improve neonatal outcomes. American Journal of Obstetrics and Gynecology 227:2, pages 296.e1-296.e18.
Crossref
Dereje W. Gudicha, Roberto Romero, Nardhy Gomez-Lopez, Jose Galaz, Gaurav Bhatti, Bogdan Done, Eunjung Jung, Dahiana M. Gallo, Mariachiara Bosco, Manaphat Suksai, Ramiro Diaz-Primera, Piya Chaemsaithong, Francesca Gotsch, Stanley M. Berry, Tinnakorn Chaiworapongsa & Adi L. Tarca. (2022) The amniotic fluid proteome predicts imminent preterm delivery in asymptomatic women with a short cervix. Scientific Reports 12:1.
Crossref
Ji Su Seong, Chan-Wook Park, Kyung Chul Moon, Joong Shin Park & Jong Kwan Jun. (2021) Necrotizing funisitis is an indicator that intra-amniotic inflammatory response is more severe and amnionitis is more frequent in the context of the extension of inflammation into Wharton's jelly. Taiwanese Journal of Obstetrics and Gynecology 60:5, pages 840-850.
Crossref
Drucilla J. Roberts & Carolyn Polizzano. 2021. Atlas of Placental Pathology. Atlas of Placental Pathology 117 180 .
Joon Hyung Lee, Chan-Wook Park, Kyung Chul Moon, Joong Shin Park & Jong Kwan Jun. (2021) The Inflammatory Milieu of Amniotic Fluid Increases with Chorio-Deciduitis Grade in Inflammation-Restricted to Choriodecidua, but Not Amnionitis, of Extra-Placental Membranes. Journal of Clinical Medicine 10:14, pages 3041.
Crossref
Soo Ran Choi, Taehee Kim, Yejeong Kim, Sugyung Jung & Suk Jin Choi. (2021) The Relationship Between Matrix Metalloproteinase-8 in After Birth Oral Fluid and Acute Histologic Chorioamnionitis in Preterm Delivery. Reproductive Sciences 28:7, pages 2023-2028.
Crossref
Greta Balciuniene, Violeta Gulbiniene, Irena Dumalakiene, Rita Viliene, Daiva Bartkeviciene, Ingrida Pilypiene, Grazina S. Drasutiene & Diana Ramasauskaite. (2021) Prognostic Markers for Chorioamnionitis: IL-6, TNF-α, and MMP-8 in Vaginally Obtained Amniotic Fluid. Journal of Clinical Medicine 10:5, pages 1136.
Crossref
Tsung-Po Lai, Mark Simpson, Krunal Patel, Simon Verhulst, Jungsik Noh, Natalie Roche, Debra Heller, George Guirguis, Jerry W. Shay, Utz Herbig & Abraham Aviv. (2021) Telomeres and replicative cellular aging of the human placenta and chorioamniotic membranes. Scientific Reports 11:1.
Crossref
Nardhy Gomez-Lopez & Roberto Romero. 2021. Reproductive Immunology. Reproductive Immunology 207 237 .
Augusto F. Schmidt, Paranthaman S. Kannan, James Bridges, Pietro Presicce, Courtney M. Jackson, Lisa A. Miller, Suhas G. Kallapur, Claire A. Chougnet & Alan H. Jobe. (2020) Prenatal inflammation enhances antenatal corticosteroid–induced fetal lung maturation. JCI Insight 5:24.
Crossref
Mikael S. Huhtala, Kristiina Tertti, Juuso Juhila, Timo Sorsa & Tapani Rönnemaa. (2020) Metformin and insulin treatment of gestational diabetes: effects on inflammatory markers and IGF-binding protein-1 – secondary analysis of a randomized controlled trial. BMC Pregnancy and Childbirth 20:1.
Crossref
Kyung Joon Oh, JoonHo Lee, Roberto Romero, Hyun Soo Park, Joon-Seok Hong & Bo Hyun Yoon. (2020) A new rapid bedside test to diagnose and monitor intraamniotic inflammation in preterm PROM using transcervically collected fluid. American Journal of Obstetrics and Gynecology 223:3, pages 423.e1-423.e15.
Crossref
Amy G. Brown, Monique E. Maubert, Lauren Anton, Laura M. Heiser & Michal A. Elovitz. (2019) The tracking of lipopolysaccharide through the feto‐maternal compartment and the involvement of maternal TLR4 in inflammation‐induced fetal brain injury. American Journal of Reproductive Immunology 82:6.
Crossref
Bo Hyun Yoon, Roberto Romero, Jee Yoon Park, Kyung Joon Oh, JoonHo Lee, Agustin Conde-Agudelo & Joon-Seok Hong. (2019) Antibiotic administration can eradicate intra-amniotic infection or intra-amniotic inflammation in a subset of patients with preterm labor and intact membranes. American Journal of Obstetrics and Gynecology 221:2, pages 142.e1-142.e22.
Crossref
Kyung Joon Oh, Roberto Romero, Jee Yoon Park, JoonHo Lee, Agustin Conde-Agudelo, Joon-Seok Hong & Bo Hyun Yoon. (2019) Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency. American Journal of Obstetrics and Gynecology 221:2, pages 140.e1-140.e18.
Crossref
Kyung Joon Oh, Roberto Romero, Jee Yoon Park, Joon-Seok Hong & Bo Hyun Yoon. (2019) The earlier the gestational age, the greater the intensity of the intra-amniotic inflammatory response in women with preterm premature rupture of membranes and amniotic fluid infection by Ureaplasma species . Journal of Perinatal Medicine 47:5, pages 516-527.
Crossref
Gregory P. Goldstein, Stephanie A. Leonard, Peiyi Kan, Euna B. Koo, Henry C. Lee & Suzan L. Carmichael. (2019) Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity. Journal of Perinatology 39:7, pages 964-973.
Crossref
Kyung Joon Oh, Roberto Romero, Jee Yoon Park, Jihyun Kang, Joon-Seok Hong & Bo Hyun Yoon. (2019) A high concentration of fetal fibronectin in cervical secretions increases the risk of intra-amniotic infection and inflammation in patients with preterm labor and intact membranes. Journal of Perinatal Medicine 47:3, pages 288-303.
Crossref
Valeria Garcia-Flores, Roberto Romero, Derek Miller, Yi Xu, Bogdan Done, Chharitha Veerapaneni, Yaozhu Leng, Marcia Arenas-Hernandez, Nabila Khan, Bogdan Panaitescu, Sonia S. Hassan, Luis Marat Alvarez-Salas & Nardhy Gomez-Lopez. (2018) Inflammation-Induced Adverse Pregnancy and Neonatal Outcomes Can Be Improved by the Immunomodulatory Peptide Exendin-4. Frontiers in Immunology 9.
Crossref
Roberto Romero, Piya Chaemsaithong, Noppadol Chaiyasit, Nikolina Docheva, Zhong Dong, Chong Jai Kim, Yeon Mee Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Bo Hyun Yoon, Tinnakorn Chaiworapongsa, Lami Yeo, Sonia S. Hassan, Offer Erez & Steven J. Korzeniewski. (2017) CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor. American Journal of Reproductive Immunology 78:1, pages e12685.
Crossref
E. Maisonneuve, P.-Y. Ancel, L. Foix-L’Hélias, S. Marret & G. Kayem. (2017) Impact of clinical and/or histological chorioamnionitis on neurodevelopmental outcomes in preterm infants: A literature review. Journal of Gynecology Obstetrics and Human Reproduction 46:4, pages 307-316.
Crossref
Noppadol Chaiyasit, Roberto Romero, Piya Chaemsaithong, Nikolina Docheva, Gaurav Bhatti, Juan Pedro Kusanovic, Zhong Dong, Lami Yeo, Percy Pacora, Sonia S. Hassan & Offer Erez. (2017) Clinical chorioamnionitis at term VIII: a rapid MMP-8 test for the identification of intra-amniotic inflammation. Journal of Perinatal Medicine 45:5.
Crossref
Tarja Myntti, Leena Rahkonen, Irmeli Nupponen, Anu Pätäri-Sampo, Minna Tikkanen, Timo Sorsa, Juuso Juhila, Sture Andersson, Jorma Paavonen & Vedran Stefanovic. (2017) Amniotic Fluid Infection in Preterm Pregnancies with Intact Membranes. Disease Markers 2017, pages 1-9.
Crossref
Emma L. Sweeney, Samantha J. Dando, Suhas G. Kallapur & Christine L. Knox. (2017) The Human Ureaplasma Species as Causative Agents of Chorioamnionitis. Clinical Microbiology Reviews 30:1, pages 349-379.
Crossref
T Myntti, L Rahkonen, A Pätäri-Sampo, M Tikkanen, T Sorsa, J Juhila, O Helve, S Andersson, J Paavonen & V Stefanovic. (2016) Comparison of amniotic fluid matrix metalloproteinase-8 and cathelicidin in the diagnosis of intra-amniotic infection. Journal of Perinatology 36:12, pages 1049-1054.
Crossref
Joohee Choi, Jeong Woo Park, Byoung Jae Kim, Ye-Jin Choi, Jong Hee Hwang & Seung Mi Lee. (2016) Funisitis is more common in cervical insufficiency than in preterm labor and preterm premature rupture of membranes. Journal of Perinatal Medicine 44:5.
Crossref
Jodi K. Regan, Paranthaman S. Kannan, Matthew W. Kemp, Boris W. Kramer, John P. Newnham, Alan H. Jobe & Suhas G. Kallapur. (2016) Damage-Associated Molecular Pattern and Fetal Membrane Vascular Injury and Collagen Disorganization in Lipopolysaccharide-Induced Intra-amniotic Inflammation in Fetal Sheep. Reproductive Sciences 23:1, pages 69-80.
Crossref
Anna Cyganek, Aleksandra Wyczalkowska-Tomasik, Patrycja Jarmuzek, Barbara Grzechocinska, Zoulikha Jabiry-Zieniewicz, Leszek Paczek & Miroslaw Wielgos. (2016) Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period. BioMed Research International 2016, pages 1-5.
Crossref
Roberto Romero, Piya Chaemsaithong, Nikolina Docheva, Steven J. Korzeniewski, Adi L. Tarca, Gaurav Bhatti, Zhonghui Xu, Juan P. Kusanovic, Zhong Dong, Noppadol Chaiyasit, Ahmed I. Ahmed, Bo Hyun Yoon, Sonia S. Hassan, Tinnakorn Chaiworapongsa & Lami Yeo. (2015) Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile. Journal of Perinatal Medicine 0:0.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.