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Original Article

Tetrabromobisphenol A has immunosuppressive effects on human natural killer cells

, &
Pages 285-292 | Received 06 Jul 2009, Accepted 12 Aug 2009, Published online: 05 Oct 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Sharif Anisuzzaman & Margaret M. Whalen. (2016) Tetrabromobisphenol A and hexabromocyclododecane alter secretion of IL-1β from human immune cells. Journal of Immunotoxicology 13:3, pages 403-416.
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Felicia Udoji, Tamara Martin, Rachel Etherton & Margaret M. Whalen. (2010) Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. Journal of Immunotoxicology 7:3, pages 205-212.
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Articles from other publishers (42)

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Teruyuki Nakao, Hideki Kakutani, Tomohiro Yuzuriha & Souichi Ohta. (2022) Distribution, Metabolism, Excretion, and Lactational Transfer to Pups of Tetrabromobisphenol A and Its Metabolites in C57BL/6 Mice. BPB Reports 5:3, pages 50-58.
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Joana Feiteiro, Melissa Mariana & Elisa Cairrão. (2021) Health toxicity effects of brominated flame retardants: From environmental to human exposure. Environmental Pollution 285, pages 117475.
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Wenjuan Zhang, Aijing Li, Yu Pan, Fengbang Wang, Ming Li, Yong Liang, Xinglei Yao, Jinghai Song, Maoyong Song & Guibin Jiang. (2021) Tetrabromobisphenol A induces THR β-mediated inflammation and uterine injury in mice at environmentally relevant exposure concentrations. Journal of Hazardous Materials 407, pages 124859.
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Matthew V Gomez, Moumita Dutta, Alexander Suvorov, Xiaojian Shi, Haiwei Gu, Sridhar Mani & Julia Yue Cui. (2021) Early Life Exposure to Environmental Contaminants (BDE-47, TBBPA, and BPS) Produced Persistent Alterations in Fecal Microbiome in Adult Male Mice. Toxicological Sciences 179:1, pages 14-30.
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Masahiro Yamasaki, Shinya Hasegawa, Masahiko Imai, Tetsuya Fukui & Noriko Takahashi. (2021) Browning Effect of Brominated Flame Retardant, TBBP-A, on Undifferentiated Adipocytes. BPB Reports 4:1, pages 41-46.
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Yinan Wang, Wenjuan Zhang, Aijing Li & Maoyong Song. (2021) Tetrachlorobisphenol A induced immunosuppression and uterine injury in mice. Ecotoxicology and Environmental Safety 207, pages 111527.
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Hui Zhou, Nuoya Yin & Francesco Faiola. (2020) Tetrabromobisphenol A (TBBPA): A controversial environmental pollutant. Journal of Environmental Sciences 97, pages 54-66.
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Irina Elcheva, Mechelle Sneed, Scott Frazee, Zhenqiu Liu, Junjia Zhu, Tyler Wood, Sara Hendrickson, Chuck Oehler, Brad Garcia & Vladimir S. Spiegelman. (2019) A novel hiPSC-derived system for hematoendothelial and myeloid blood toxicity screens identifies compounds promoting and inhibiting endothelial-to-hematopoietic transition. Toxicology in Vitro 61, pages 104622.
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Yunjiang Yu, Ziling Yu, Haibo Chen, Yajing Han, Mingdeng Xiang, Xichao Chen, Ruixue Ma & Zhengdong Wang. (2019) Tetrabromobisphenol A: Disposition, kinetics and toxicity in animals and humans. Environmental Pollution 253, pages 909-917.
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Shijin Wu, Zhenzhen Zhu, Jialin Chen, Mei Wu & Lequan Qiu. (2019) Transcriptomic analyses of human bronchial epithelial cells BEAS‐2B exposed to brominated flame retardant (tetrabromobisphenol A). Environmental Toxicology 34:6, pages 742-752.
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Sharia Yasmin & Margaret Whalen. (2018) Flame retardants, hexabromocyclododecane (HCBD) and tetrabromobisphenol a (TBBPA), alter secretion of tumor necrosis factor alpha (TNFα) from human immune cells. Archives of Toxicology 92:4, pages 1483-1494.
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Jacek Lenart, Elzbieta Zieminska, Dominik Diamandakis & Jerzy W. Lazarewicz. (2017) Altered expression of genes involved in programmed cell death in primary cultured rat cerebellar granule cells acutely challenged with tetrabromobisphenol A. NeuroToxicology 63, pages 126-136.
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KE Pelch, JA Wignall, AE Goldstone, PK Ross, RB Blain, AJ Shapiro, SD Holmgren, J-H Hsieh, D Svoboda, SS Auerbach, FM Parham, SA Masten & KA Thayer. (2017) NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives. NTP Research Report.
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Yanying Wang, Fang Chen, Xiaoxue Ye, Tsunghsueh Wu, Kangbing Wu & Chunya Li. (2017) Photoelectrochemical immunosensing of tetrabromobisphenol A based on the enhanced effect of dodecahedral gold nanocrystals/MoS2 nanosheets. Sensors and Actuators B: Chemical 245, pages 205-212.
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Samantha M. Hall, Sherry J. Coulter, Gabriel A. Knudsen, J. Michael Sanders & Linda S. Birnbaum. (2017) Gene expression changes in immune response pathways following oral administration of tetrabromobisphenol A (TBBPA) in female Wistar Han rats. Toxicology Letters 272, pages 68-74.
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Arnaud Bruyere, Céline Hubert, Marc Le Vee, Lisa Chedik, Katia Sayyed, Bruno Stieger, Claire Denizot, Yannick Parmentier & Olivier Fardel. (2017) Inhibition of SLC drug transporter activities by environmental bisphenols. Toxicology in Vitro 40, pages 34-44.
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J.K. Dunnick, D.L. Morgan, S.A. Elmore, K. Gerrish, A. Pandiri, T.V. Ton, K.R. Shockley & B.A. Merrick. (2017) Tetrabromobisphenol A activates the hepatic interferon pathway in rats. Toxicology Letters 266, pages 32-41.
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Katharina R. Beck, Tanja J. Sommer, Daniela Schuster & Alex Odermatt. (2016) Evaluation of tetrabromobisphenol A effects on human glucocorticoid and androgen receptors: A comparison of results from human- with yeast-based in vitro assays. Toxicology 370, pages 70-77.
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Haifa Almughamsi & Margaret M. Whalen. (2015) Hexabromocyclododecane and tetrabromobisphenol A alter secretion of interferon gamma (IFN-γ) from human immune cells. Archives of Toxicology 90:7, pages 1695-1707.
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Hongbo Gu, Han Lou, Jinglin Tian, Shulin Liu & Yulin Tang. (2016) Reproducible magnetic carbon nanocomposites derived from polystyrene with superior tetrabromobisphenol A adsorption performance. Journal of Materials Chemistry A 4:26, pages 10174-10185.
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Kai Wang, Zhiping Liu, Pei Ji, Jianfeng Liu, Sergei A. Eremin, Qing X. Li, Ji Li & Ting Xu. (2016) A camelid VHH-based fluorescence polarization immunoassay for the detection of tetrabromobisphenol A in water. Analytical Methods 8:39, pages 7265-7271.
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Ema Akiyama, Hideki Kakutani, Teruyuki Nakao, Yuka Motomura, Yuki Takano, Ryota Sorakubo, Ayami Mizuno, Osamu Aozasa, Keisuke Tachibana, Takefumi Doi & Souichi Ohta. (2015) Facilitation of adipocyte differentiation of 3T3-L1 cells by debrominated tetrabromobisphenol A compounds detected in Japanese breast milk. Environmental Research 140, pages 157-164.
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Christopher A. Barrett, David A. Orban, Shannon E. Seebeck, Luis E. Lowe & Janel E. Owens. (2015) Development of a low-density-solvent dispersive liquid-liquid microextraction with gas chromatography and mass spectrometry method for the quantitation of tetrabromobisphenol-A from dust. Journal of Separation Science 38:14, pages 2503-2509.
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Thora Lieke, Christian Steinberg, Jingjuan Ju & Nadine Saul. (2015) Natural Marine and Synthetic Xenobiotics Get on Nematode’s Nerves: Neuro-Stimulating and Neurotoxic Findings in Caenorhabditis elegans. Marine Drugs 13:5, pages 2785-2812.
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Teruyuki Nakao, Ema Akiyama, Hideki Kakutani, Ayami Mizuno, Osamu Aozasa, Yukiko Akai & Souichi Ohta. (2015) Levels of Tetrabromobisphenol A, Tribromobisphenol A, Dibromobisphenol A, Monobromobisphenol A, and Bisphenol A in Japanese Breast Milk. Chemical Research in Toxicology 28:4, pages 722-728.
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Teruyuki NAKAO, Ema AKIYAMA, Hideki KAKUTANI, Ayami MIZUNO, Osamu AOZASA, Yukiko AKAI & Souichi OHTA. (2015) <b>Detection of Tribromobisphenol A as Debrominated Compounds of </b><b>Tetrabromobisphenol A in Breast Milk Collected in Japan </b>. Journal of Environmental Chemistry 25:2, pages 69-77.
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Hae-Ryung Park, Patricia W. Kamau, Cassandra Korte & Rita Loch-Caruso. (2014) Tetrabromobisphenol A activates inflammatory pathways in human first trimester extravillous trophoblasts in vitro. Reproductive Toxicology 50, pages 154-162.
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Anita Cato, Lindsay Celada, Esther Caroline Kibakaya, Nadia Simmons & Margaret M. Whalen. (2014) Brominated flame retardants, tetrabromobisphenol A and hexabromocyclododecane, activate mitogen-activated protein kinases (MAPKs) in human natural killer cells. Cell Biology and Toxicology 30:6, pages 345-360.
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Anna K. Wojtowicz, Konrad A. Szychowski & Małgorzata Kajta. (2013) PPAR-γ Agonist GW1929 But Not Antagonist GW9662 Reduces TBBPA-Induced Neurotoxicity in Primary Neocortical Cells. Neurotoxicity Research 25:3, pages 311-322.
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Dan Bu, Huisheng Zhuang, Xinchu Zhou & Guangxin Yang. (2014) Biotin–streptavidin enzyme-linked immunosorbent assay for detecting Tetrabromobisphenol A in electronic waste. Talanta 120, pages 40-46.
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P.D. Jones, R. Mankidy & J. Newsted. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 490 492 .
Susan D. Shaw, Jennifer H. Harris, Michelle L. Berger, Bikram Subedi & Kurunthachalam Kannan. 2014. Toxicants in Food Packaging and Household Plastics. Toxicants in Food Packaging and Household Plastics 61 93 .
Gina Di Napoli-Davis & Janel E. Owens. (2013) Quantitation of tetrabromobisphenol-A from dust sampled on consumer electronics by dispersed liquid-liquid microextraction. Environmental Pollution 180, pages 274-280.
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Tasia Hurd‐Brown, Felicia Udoji, Tamara Martin & Margaret M. Whalen. (2012) Effects of DDT and triclosan on tumor‐cell binding capacity and cell‐surface protein expression of human natural killer cells. Journal of Applied Toxicology 33:6, pages 495-502.
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Yunhai Zhang, Yulin Tang, Shuyan Li & Shuili Yu. (2013) Sorption and removal of tetrabromobisphenol A from solution by graphene oxide. Chemical Engineering Journal 222, pages 94-100.
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Ting Xu, Jia Wang, Shang-zhong Liu, Cong Lü, Weilin L. Shelver, Qing X. Li & Ji Li. (2012) A highly sensitive and selective immunoassay for the detection of tetrabromobisphenol A in soil and sediment. Analytica Chimica Acta 751, pages 119-127.
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Tasia Hurd, Jasmine Walker & Margaret M. Whalen. (2012) Pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells. Journal of Applied Toxicology 32:8, pages 627-634.
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E.K. Kopp, H. Fromme & W. Völkel. (2012) Analysis of common and emerging brominated flame retardants in house dust using ultrasonic assisted solvent extraction and on-line sample preparation via column switching with liquid chromatography–mass spectrometry. Journal of Chromatography A 1241, pages 28-36.
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