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Research Article

Evaluation of primary and secondary responses to a T-cell-dependent antigen, keyhole limpet hemocyanin, in rats

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Pages 40-48 | Received 09 Jan 2012, Accepted 30 Apr 2012, Published online: 07 Sep 2012

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Read on this site (2)

Wenhua Zhong, Penghuan Chang, Lianfang Gan, Lifan Zhong & Zhaoxin Yang. (2022) A T-cell-dependent antibody response (TDAR) method in BALB/c mice based on a cytometric bead array. Journal of Immunotoxicology 19:1, pages 34-40.
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Penghuan Chang, Ling Huang, Mianqing Huang, Shuhong Tian & Zhaoxin Yang. (2019) Improvement and optimization of a T-cell-dependent antibody response (TDAR) method for BALB/c mice using keyhole limpet hemocyanin (KLH) as specific antigen. Journal of Immunotoxicology 16:1, pages 149-154.
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Articles from other publishers (18)

Beibei Zhao, Renhui Mei, Le Li, Di Hu & Lei Li. (2024) Enhancing immune responses in Japanese flounder (Paralichthys olivaceus) to Keyhole Limpet Hemocyanin by intramuscularly conjugating a new type of chemokine, JfCXCL8_L1b. Aquaculture 581, pages 740399.
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Amany RAMAH, Masahiro YASUDA, Yuki OHASHI, Shoichiro IMATAKE, Noriko IMAIZUMI, Tetsuo KIDA, Tenya YANAGITA, Ryoko UEMURA, Mahmoud BAAKHTARI, Hatem H. BAKRY, Nabila M. ABDELALEEM & Elham A EL-SHEWY. (2022) Protective effects of probiotics against tannin-induced immunosuppression in broiler chickens. Bioscience of Microbiota, Food and Health 41:4, pages 168-176.
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Cathy Nguyen & Lars Petter Jordheim. (2023) Évaluation de l’immunotoxicité en recherche et dans le cadre du développement biomédical. Biologie Aujourd’hui 216:3-4, pages 167-181.
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Sylvain De Guise & Milton Levin. (2021) Suppression of Th2 cytokines as a potential mechanism for reduced antibody response following PFOA exposure in female B6C3F1 mice. Toxicology Letters 351, pages 155-162.
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Uttapol Permpoon, Fatima Khan, Sri Murugan Poonkavithai Vadevoo, Smriti Gurung, Gowri Rangaswamy Gunassekaran, Min-Jong Kim, Sang-Hyun Kim, Peti Thuwajit & Byungheon Lee. (2020) Inhibition of Tumor Growth against Chemoresistant Cholangiocarcinoma by a Proapoptotic Peptide Targeting Interleukin-4 Receptor. Molecular Pharmaceutics 17:11, pages 4077-4088.
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Vladimir Talayev, Irina Zaichenko, Maria Svetlova, Alexei Matveichev, Olga Babaykina, Elena Voronina & Andrei Mironov. (2020) Low-dose influenza vaccine Grippol Quadrivalent with adjuvant Polyoxidonium induces a T helper-2 mediated humoral immune response and increases NK cell activity. Vaccine 38:42, pages 6645-6655.
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Amany Ramah, Masahiro Yasuda, Yuki Ohashi, Marimu Urakawa, Tetsuo Kida, Tenya Yanagita, Ryoko Uemura, Hatem H. Bakry, Nabila M. Abdelaleem & Elham A. El-Shewy. (2020) Different doses of tannin reflect a double-edged impact on broiler chicken immunity. Veterinary Immunology and Immunopathology 220, pages 109991.
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Michelle L. Salazar, Josè M. Jimènez, Javiera Villar, Maira Rivera, Mauricio Báez, Augusto Manubens & María Inès Becker. (2019) N-Glycosylation of mollusk hemocyanins contributes to their structural stability and immunomodulatory properties in mammals. Journal of Biological Chemistry 294:51, pages 19546-19564.
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Bunichiro Ogawa, Yutaka Nakanishi, Tomoko Koyama, Kazunori Arima & Minoru Sasaki. (2019) Strain differences in histopathological features of lymphoid tissues of SD and F344 rats in a T cell-dependent antibody response assay of cyclophosphamide. Journal of Toxicologic Pathology 32:3, pages 143-154.
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X. Wang, A. Coppi & H. Lebrec. 2018. Comprehensive Toxicology. Comprehensive Toxicology 376 398 .
Ze-Min Lin, Xiao-Qian Yang, Feng-Hua Zhu, Shi-Jun He, Wei Tang & Jian-Ping Zuo. (2016) Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells. Scientific Reports 6:1.
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Adrienne Mikovari, Jonathan Williams, Frank Oakes, Robert Brandon Lincicum, Amanda J. Zellmer & Gary G. Martin. (2015) Radula Development in the Giant Key-Hole Limpet Megathura crenulata . Journal of Shellfish Research 34:3, pages 893-902.
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Jorrit J. Hornberg, Morten Laursen, Nina Brenden, Mikael Persson, Annemette V. Thougaard, Dorthe B. Toft & Tomas Mow. (2014) Exploratory toxicology as an integrated part of drug discovery. Part II: Screening strategies. Drug Discovery Today 19:8, pages 1137-1144.
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Florence G. Burleson & Stefanie C.M. Burleson. 2014. The Role of the Study Director in Nonclinical Studies. The Role of the Study Director in Nonclinical Studies 393 404 .
Hervé Lebrec, Brigitte Molinier, Darrell Boverhof, Mark Collinge, Wendy Freebern, Kristin Henson, Daniel T. Mytych, Hans D. Ochs, Ronald Wange, Yung Yang, Lei Zhou, Joshua Arrington, Marie Soleil Christin-Piché & Jacintha Shenton. (2014) The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: Study design, data analysis, interpretation. Regulatory Toxicology and Pharmacology 69:1, pages 7-21.
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Mitsuhiro Fujihara, Daisuke Takahashi, Hideki Abe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Hisami Ikeda & Hiroshi Azuma. (2014) Primary and Secondary Immune Responses to Keyhole Limpet Hemocyanin in Rats After Infusion of Hemoglobin Vesicle, an Artificial Oxygen Carrier. Artificial Organs 38:3, pages 234-238.
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Paola Kinara Reyes Loyola, R. Campos-Rodríguez, Martiniano Bello, S. Rojas-Hernández, Mirko Zimic, Miguel Quiliano, Verónica Briz, M. Angeles Muñoz-Fernández, Luis Tolentino-López & Jose Correa-Basurto. (2013) Theoretical analysis of the neuraminidase epitope of the Mexican A H1N1 influenza strain, and experimental studies on its interaction with rabbit and human hosts. Immunologic Research 56:1, pages 44-60.
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Ryota KawaiTetsuo AidaHiroyuki HattoriTadashi FurukawaKazuhiko MoriWataru TakasakiNobuyuki Takahashi & Teruo Kawada. (2013) Evaluation of canine T-cell dependent antibody response to the primary and secondary immunization with keyhole limpet hemocyanin. The Journal of Toxicological Sciences 38:4, pages 571-579.
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