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Journal of Immunotoxicology Volume 11, 2014 - Issue 1
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Research Article

Measuring T-cell responses against LCV and CMV in cynomolgus macaques using ELISPOT: Potential application to non-clinical testing of immunomodulatory therapeutics

Cris KamperschroerDrug Safety Research and Development, Pfizer Global Research and Development Pfizer, Inc., Groton, CTUSACorrespondence[email protected]
,
Lynn M. O’DonnellDrug Safety Research and Development, Pfizer Global Research and Development Pfizer, Inc., Groton, CTUSA
,
Patricia A. SchneiderDrug Safety Research and Development, Pfizer Global Research and Development Pfizer, Inc., Groton, CTUSA
,
Dingzhou LiDrug Safety Research and Development, Pfizer Global Research and Development Pfizer, Inc., Groton, CTUSA
,
Marc RoyDrug Safety Research and Development, Pfizer Global Research and Development Pfizer, Inc., Groton, CTUSA
,
Timothy M. CoskranDrug Safety Research and Development, Pfizer Global Research and Development Pfizer, Inc., Groton, CTUSA
&
Thomas T. KawabataDrug Safety Research and Development, Pfizer Global Research and Development Pfizer, Inc., Groton, CTUSA
 show all
Pages 35-43 | Received 25 Nov 2012, Accepted 07 Jan 2013, Published online: 06 Mar 2013

Citations (8)

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Cris Kamperschroer, Brendon Frank, Caroline Genell, Hervé Lebrec, Shermaine Mitchell-Ryan, Brigitte Molinier, Courtni Newsome, Marie-Soleil Piche, Daniel Weinstock, Mark Collinge, Wendy Freebern & Daniel Rubio. (2023) Current approaches to evaluate the function of cytotoxic T-cells in non-human primates. Journal of Immunotoxicology 20:1.
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Richard Graveline, Morad Haida, Carolyne Dumont, Dominic Poulin, Florence Poitout-Belissent, Rana Samadfam, Sven Kronenberg, Franziska Regenass-Lechner, Rodney Prell & Marie-Soleil Piche. (2022) Development of a nonhuman primate challenge model to evaluate CD8+ T cell responses to an adenovirus-based vaccine expressing SIV proteins upon repeat-dose treatment with checkpoint inhibitors. mAbs 14:1.
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Brendon Frank, Yu-Ling Wei, Kyung-Hoon Kim, Abraham Guerrero, Hervé Lebrec, Mercedesz Balazs & Xiaoting Wang. (2018) Development of a BiTE®-mediated CD8+ cytotoxic T-lymphocyte activity assay to assess immunomodulatory potential of drug candidates in Cynomolgus macaque. Journal of Immunotoxicology 15:1, pages 119-125.
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Articles from other publishers (5)

Martyn T. Smith, Kathryn Z. Guyton, Nicole Kleinstreuer, Alexandre Borrel, Andres Cardenas, Weihsueh A. Chiu, Dean W. Felsher, Catherine F. Gibbons, William H. GoodsonIIIIII, Keith A. Houck, Agnes B. Kane, Michele A. La Merrill, Herve Lebrec, Leroy Lowe, Cliona M. McHale, Sheroy Minocherhomji, Linda Rieswijk, Martha S. Sandy, Hideko Sone, Amy Wang, Luoping Zhang, Lauren Zeise & Mark Fielden. (2020) The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them. Cancer Epidemiology, Biomarkers & Prevention 29:10, pages 1887-1903.
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Sally E. Henderson, Sara C. Pfeiffer, Joseph Novak & Tracy A. Peace. (2020) Large granular lymphocytosis in a cynomolgus macaque ( Macaca fascicularis ) with a subclinical Trypanosoma cruzi infection . Veterinary Clinical Pathology 49:3, pages 382-388.
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Cris Kamperschroer, Mark M. Gosink, Steven W. Kumpf, Lynn M. O’Donnell & Karrie R. Tartaro. (2016) The genomic sequence of lymphocryptovirus from cynomolgus macaque. Virology 488, pages 28-36.
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Chandrassegar Saravanan, Vito G. Sasseville & Keith G. Mansfield. 2015. The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment. The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment 187 213 .
Cris Kamperschroer, Karrie Tartaro & Steven W. Kumpf. (2014) Quantitative PCR assays reveal high prevalence of lymphocryptovirus as well as lytic phase gene expression in peripheral blood cells of cynomolgus macaques. Journal of Virological Methods 207, pages 220-225.
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