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Short Reports

Status epilepticus and wide-complex tachycardia secondary to diphenhydramine overdose

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Pages 945-948 | Received 07 Jun 2010, Accepted 22 Sep 2010, Published online: 20 Dec 2010

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Joseph Clemons, Arvinder Jandu, Brandon Stein & Michael Chary. (2022) Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports. Clinical Toxicology 60:5, pages 550-558.
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Adrienne R. Hughes, Amber Lin & Robert G. Hendrickson. (2021) Clinical and patient characteristics associated with severe outcome in diphenhydramine toxicity. Clinical Toxicology 59:10, pages 918-925.
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Salim M Bastaki, Yousef M Abdulrazzaq, Mohamed Shafiullah, Małgorzata Więcek, Katarzyna Kieć-Kononowicz & Bassem Sadek. (2018) Anticonvulsant and reproductive toxicological studies of the imidazole-based histamine H3R antagonist 2-18 in mice. Drug Design, Development and Therapy 12, pages 179-194.
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Sophie Gosselin, Lotte C. G. Hoegberg, Robert. S. Hoffman, Andis Graudins, Christine M. Stork, Simon H. L. Thomas, Samuel J. Stellpflug, Bryan D. Hayes, Michael Levine, Martin Morris, Andrea Nesbitt-Miller, Alexis F. Turgeon, Benoit Bailey, Diane P. Calello, Ryan Chuang, Theodore C. Bania, Bruno Mégarbane, Ashish Bhalla & Valéry Lavergne. (2016) Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clinical Toxicology 54:10, pages 899-923.
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Joshua N. Nogar, Alicia B. Minns, Davut J. Savaser & Bihn T. Ly. (2011) Severe sodium channel blockade and cardiovascular collapse due to a massive Lamotrigine overdose. Clinical Toxicology 49:9, pages 854-857.
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Articles from other publishers (35)

Kimberly Rockley, Ruth Roberts, Hannah Jennings, Karen Jones, Myrtle Davis, Paul Levesque & Michael Morton. (2023) An integrated approach for early in vitro seizure prediction utilizing hiPSC neurons and human ion channel assays . Toxicological Sciences 196:1, pages 126-140.
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Jin Zhai, Martin Traebert, Kurt Zimmermann, Annie Delaunois, Leandro Royer, Giorgia Salvagiotto, Coby Carlson & Armando Lagrutta. (2023) Comparative study for the IMI2-NeuroDeRisk project on microelectrode arrays to derisk drug-induced seizure liability. Journal of Pharmacological and Toxicological Methods 123, pages 107297.
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Dongsun Kim, Hyun Young Shin & Bon D. Ku. (2023) A case of diphenhydramine intoxication showing prolonged false positive tricyclic antidepressant in the urine assay. Asian Biomedicine 17:1, pages 39-42.
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Yousef M. Abdulrazzaq, Salim M.A. Bastaki & Ernest Adeghate. (2022) Histamine H3 receptor antagonists – Roles in neurological and endocrine diseases and diabetes mellitus. Biomedicine & Pharmacotherapy 150, pages 112947.
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Haley N. Phillips & Laura Tormoehlen. (2022) Toxin-Induced Seizures ∗Adapted from “Toxin-Induced Seizures” in Neurologic Clinics, November 2020. Emergency Medicine Clinics of North America 40:2, pages 417-430.
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George Sam Wang, Kate M. Reynolds, William Banner, G. Randall Bond, Ralph E. Kauffman, Robert B. Palmer, Ian M. Paul, Malin Rapp-Olsson, Jody L. Green & Richard C. Dart. (2022) Adverse Events Related to Accidental Unintentional Ingestions From Cough and Cold Medications in Children. Pediatric Emergency Care 38:1, pages e100-e104.
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Sanjay Mohan, Timothy Backus, Emma Furlano, Mary Ann Howland, Silas W. Smith & Mark K. Su. (2021) A Case of Massive Diphenhydramine and Naproxen Overdose. The Journal of Emergency Medicine 61:3, pages 259-264.
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Timothy Nguyen, Beatrice Polyakova, John Cerenzio & Josh Renzo Ramilo. (2021) Diphenhydramine Use in End-Stage Kidney Disease. American Journal of Therapeutics 28:2, pages e232-e237.
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Glenn A. Burket, B. Zane Horowitz, Robert G. Hendrickson & Gillian A. Beauchamp. (2020) Endotracheal Intubation in the Pharmaceutical-Poisoned Patient: a Narrative Review of the Literature. Journal of Medical Toxicology 17:1, pages 61-69.
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Haley N. Phillips & Laura Tormoehlen. (2020) Toxin-Induced Seizures. Neurologic Clinics 38:4, pages 867-879.
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Mohamed Kreir, An De Bondt, Ilse Van den Wyngaert, Greet Teuns, Hua Rong Lu & David J. Gallacher. (2019) Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons. European Journal of Pharmacology 858, pages 172474.
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Derek Bauer & Mark Quigg. (2019) Optimizing Management of Medically Responsive Epilepsy. CONTINUUM: Lifelong Learning in Neurology 25:2, pages 343-361.
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Kosuke Yonemoto, Kazuo Okanari & Hiroshi Koga. (2018) Optimal Doses of H1 Antihistamines Do Not Increase Susceptibility to Febrile Convulsions in Children. Pediatric Neurology 87, pages 42-47.
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Mengxuan Gao, Hideyoshi Igata, Aoi Takeuchi, Kaoru Sato & Yuji Ikegaya. (2017) Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds. Journal of Pharmacological Sciences 133:2, pages 70-78.
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Aibek E. Mirrakhimov, Taha Ayach, Aram Barbaryan, Goutham Talari, Romil Chadha & Adam Gray. (2017) The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions. International Journal of Nephrology 2017, pages 1-8.
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Deepti Zutshi. 2017. Continuous EEG Monitoring. Continuous EEG Monitoring 361 382 .
Sara K. Lookabill, Anna Rouse Dulaney, Greene Shepherd & William P. KernsIIII. 2017. Critical Care Toxicology. Critical Care Toxicology 2967 2986 .
Silas W. Smith. 2017. Critical Care Toxicology. Critical Care Toxicology 821 841 .
Gillian A. Beauchamp, Robert G. Hendrickson & Benjamin W. Hatten. (2016) Endotracheal Intubation for Toxicologic Exposures: A Retrospective Review of Toxicology Investigators Consortium (ToxIC) Cases. The Journal of Emergency Medicine 51:4, pages 382-388.e11.
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Alisha C. Worth, Tina A. Wismer & David C. Dorman. (2016) Diphenhydramine exposure in dogs: 621 cases (2008–2013). Journal of the American Veterinary Medical Association 249:1, pages 77-82.
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Theoharis C. Theoharides & Julia M. Stewart. (2016) Antihistamines and Mental Status. Journal of Clinical Psychopharmacology 36:3, pages 195-197.
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G. A. Beauchamp, S. L. Giffin, B. Z. Horowitz, A. L. Laurie, R. Fu & R. G. Hendrickson. (2015) Poisonings Associated with Intubation: US National Poison Data System Exposures 2000–2013. Journal of Medical Toxicology 12:2, pages 157-164.
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F. Lee Cantrell, Gabriel Wardi & Charles O'Connell. (2016) Propofol Use for Toxin-Related Seizures. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 36:6, pages 702-704.
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Shawn M. Varney, Vikhyat S. Bebarta, Susan M. Boudreau, Toni E. Vargas, Maria Castaneda & Lee A. Zarzabal. (2016) Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model. Annals of Emergency Medicine 67:2, pages 196-205.e3.
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Kendra J. GrimPhilip R. FischerJason S. Eldrige. (2015) Inadvertent Iatrogenic Misuse of Intravenous Diphenhydramine in an Adolescent: Implications for Routine Medication Administration. Journal of Child and Adolescent Psychopharmacology 25:8, pages 661-663.
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Hannah R. Cock. (2015) Drug-induced status epilepticus. Epilepsy & Behavior 49, pages 76-82.
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Dimyana Abdelmalek, Evan S. Schwarz, Christopher Sampson, Sarah E. Halcomb, Craig McCammon, Anna Arroyo-Plasencia, Adam Stenger, Nick Krehbiel & Michael E. Mullins. (2014) Life-Threatening Diphenhydramine Toxicity Presenting With Seizures and a Wide Complex Tachycardia Improved With Intravenous Fat Emulsion. American Journal of Therapeutics 21:6, pages 542-544.
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Bassem Sadek, Johannes Stephan Schwed, Dhanasekaran Subramanian, Lilia Weizel, Miriam Walter, Abdu Adem & Holger Stark. (2014) Non-imidazole histamine H3 receptor ligands incorporating antiepileptic moieties. European Journal of Medicinal Chemistry 77, pages 269-279.
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Janice E. Sullivan & Mark J. McDonald. 2014. Pediatric Critical Care Medicine. Pediatric Critical Care Medicine 695 727 .
Bassem Sadek, Safa Shehab, Małgorzata Więcek, Dhanasekaran Subramanian, Mohamed Shafiullah, Katarzyna Kieć-Kononowicz & Abdu Adem. (2013) Anticonvulsant properties of histamine H3 receptor ligands belonging to N-substituted carbamates of imidazopropanol. Bioorganic & Medicinal Chemistry Letters 23:17, pages 4886-4891.
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Lena Eckes, Michael Tsokos, Sieglinde Herre, René Gapert & Sven Hartwig. (2012) Toxicological identification of diphenhydramine (DPH) in suicide. Forensic Science, Medicine, and Pathology 9:2, pages 145-153.
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M Bhowmik, R Khanam & D Vohora. (2012) Histamine H 3 receptor antagonists in relation to epilepsy and neurodegeneration: a systemic consideration of recent progress and perspectives . British Journal of Pharmacology 167:7, pages 1398-1414.
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Garry M. Walsh. 2012. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 271 276 .

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