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Research Articles

Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies

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Pages 801-809 | Received 01 Jul 2011, Accepted 21 Aug 2011, Published online: 07 Oct 2011

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Ilin KuoBelinda S. Akpa. (2013) Validity of the Lipid Sink as a Mechanism for the Reversal of Local Anesthetic Systemic Toxicity. Anesthesiology 118:6, pages 1350-1361.
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Martyn Harvey & Grant Cave. (2012) Case report: successful lipid resuscitation in multi-drug overdose with predominant tricyclic antidepressant toxidrome. International Journal of Emergency Medicine 5:1.
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. (2012) Proceedings of the Royal College of Anaesthetists Annual Congress 2012. British Journal of Anaesthesia 109:3, pages 473P-484P.
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Erik Litonius, Jana Lokajova, Gebrenegus Yohannes, Pertti J. Neuvonen, Juha M. Holopainen, Per H. Rosenberg & Susanne K. Wiedmer. (2012) In vitro and in vivo entrapment of bupivacaine by lipid dispersions. Journal of Chromatography A 1254, pages 125-131.
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Guy L. Weinberg. (2012) Lipid resuscitation. Critical Care Medicine 40:8, pages 2521.
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Joseph Eldor & Vladimir Kotlovker. (2012) Intralipid treatment: Is it only the tip of an iceberg? A new suggestion: Bone cement implantation syndrome (BCIS). journal of Anesthesiology and Clinical Science 1:1, pages 12.
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Joseph Eldor & Vladimir Kotlovker. (2012) Intralipid for Amniotic Fluid Embolism (AFE)?. Open Journal of Anesthesiology 02:04, pages 127-133.
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