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Clinical Toxicology Volume 54, 2016 - Issue 3
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Review

Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity

Michael LevineDepartment of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, CA, USA;
,
Robert S. HoffmanDivision of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, New York University School of Medicine, New York, NY, USA;
,
Valéry LavergneDepartment of Medical Biology, Sacré-Coeur Hospital, University of Montreal, Montreal, Canada;
,
Christine M. StorkDepartment of Emergency Medicine, Upstate Medical University, New York and Upstate New York Poison Center, New York, NY, USA;
,
Andis GraudinsDepartment of Medicine, School of Clinical Sciences at Monash Health, Clinical Toxicology Service at Monash Health and Monash Emergency Translational Research Group, Monash University, Clayton, Victoria, Australia;
,
Ryan ChuangDepartment of Emergency Medicine, University of Calgary, Poison and Drug Information Service, Calgary, Canada;
,
Samuel J. StellpflugDepartment of Emergency Medicine, Regions Hospital, Saint Paul, MN, USA;
,
Martin MorrisSchulich Library of Science and Engineering, McGill University, Montreal, Canada; and
,
Andrea Miller-NesbittSchulich Library of Science and Engineering, McGill University, Montreal, Canada; and
,
Sophie GosselinDepartment of Emergency Medicine, McGill University Health Centre & Department of Medicine, McGill University, Montreal, CanadaCorrespondence[email protected]
& for the Lipid Emulsion Workgroup* show all
Pages 194-221 | Received 10 Jun 2015, Accepted 25 Nov 2015, Published online: 06 Feb 2016

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Michael Levine, Jeffrey Brent, Timothy Wiegand, Bryan Maguire, Neta Cohen, David Vaerrier, Michael Beuhler, Jerrold B. Leikin, Michael Ganetsky, Samuel Stellpflug, Anne-Michelle Ruha, Jennifer Carey, Ann-Jeannette Geib, Dazhe James Cao, Kurt Kleinschmidt, Rais Vohra, Brad D. Riley, Phillip Moore, Evan Schwarz, Mark Neavyn, Daniel E. Rusyniak, Spencer Greene, Joshua Nogar, Alex Manini, Mary Wermuth, Anthony Pizon, Robert G. Hendrickson, Matthew Griswold, Kim Aldy, Paul Wax, Meghan Beth Spyres, Sharan Campleman, Erin Macdonald & Yaron Finkelstein. (2023) Lipid emulsion therapy during management of the critically-ill poisoned patient: a prospective cohort study. Clinical Toxicology 61:8, pages 584-590.
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Ju-Tae Sohn. (2022) Comment on “Efficacy of lipid emulsion therapy in treating cardiotoxicity from diphenhydramine ingestion: a review and analysis of case reports”. Clinical Toxicology 60:8, pages 992-993.
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Kotaro Hori, Tadashi Matsuura, Shogo Tsujikawa, Hideki Hino, Miyuki Kuno, Yutaka Oda, Kiyonobu Nishikawa & Takashi Mori. (2022) Lipid emulsion facilitates reversal from volatile anesthetics in a rodent model. Clinical Toxicology 60:6, pages 716-724.
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Ashok Kumar Pannu, Sahil Garg, Ashish Bhalla, Deba Prasad Dhibar & Navneet Sharma. (2022) Lipid emulsion for the treatment of acute organophosphate poisoning: an Open-Label randomized trial. Clinical Toxicology 60:5, pages 602-608.
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Joseph Clemons, Arvinder Jandu, Brandon Stein & Michael A. Chary. (2021) Early intravenous lipid emulsion therapy for diphenhydramine overdose: a case report. Toxicology Communications 5:1, pages 15-18.
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Michael E. Mullins & Donna L. Seger. (2020) Authors’ reply to Comment on antidotal use of lipid emulsion. Clinical Toxicology 58:12, pages 1357-1358.
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Robert S. Hoffman, Sophie Gosselin, Eric Villeneuve, Bryan D. Hayes, Lotte C. G. Hoegberg & Susan C. Smolinske. (2020) Comment on Antidotal use of lipid emulsion – the pendulum swings. Clinical Toxicology 58:12, pages 1355-1356.
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Michael E. Mullins & Donna L. Seger. (2020) Antidotal use of lipid emulsion – the pendulum swings. Clinical Toxicology 58:12, pages 1281-1283.
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Joe-Anthony Rotella, Shaun L. Greene, Zeff Koutsogiannis, Andis Graudins, Yit Hung Leang, Kelvin Kuan, Helen Baxter, Elyssia Bourke & Anselm Wong. (2020) Treatment for beta-blocker poisoning: a systematic review. Clinical Toxicology 58:10, pages 943-983.
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Amber M. Higgins, Randi J. LaPoint & Michael T. Vest. (2020) Intravenous lipid emulsion agglutination to Central venous catheter after treatment for intentional polysubstance overdose. Clinical Toxicology 58:5, pages 428-429.
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Bharath A. Chhabria, Ashish Bhalla, Nusrat Shafiq, Susheel Kumar, Deba Prasad Dhibar & Navneet Sharma. (2019) Lipid emulsion for acute organophosphate insecticide poisoning – a pilot observational safety study. Clinical Toxicology 57:5, pages 318-324.
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Susan Smolinske, Robert S. Hoffman, Eric Villeneuve, Lotte C. G. Hoegberg & Sophie Gosselin. (2019) Utilization of lipid emulsion therapy in fatal overdose cases: an observational study. Clinical Toxicology 57:3, pages 197-202.
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Neeraj Chhabra, Carol DesLauriers, Michael Wahl & Sean M. Bryant. (2018) Management of severe bupropion poisoning with intravenous lipid emulsion. Clinical Toxicology 56:1, pages 51-54.
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Rhadika Souza, Joshua Jauregui & Matthew Valento. (2018) Mixed propranolol and tizanidine overdose treated with intravenous lipid emulsion. Toxicology Communications 2:1, pages 71-74.
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Daniel J. Corwin, Alexis Topjian, Brenda L. Banwell & Kevin Osterhoudt. (2017) Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity. Clinical Toxicology 55:6, pages 603-607.
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Michael E. Mullins, Susan N. Miller, Candace E. Nall & William J. Meggs. (2017) Intravenous lipid emulsion therapy for flecainide toxicity. Toxicology Communications 1:1, pages 34-36.
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Michael E. Mullins. (2016) Advancing the science of antidotal use of lipid emulsion. Clinical Toxicology 54:10, pages 897-898.
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Sophie Gosselin, Lotte C. G. Hoegberg, Robert. S. Hoffman, Andis Graudins, Christine M. Stork, Simon H. L. Thomas, Samuel J. Stellpflug, Bryan D. Hayes, Michael Levine, Martin Morris, Andrea Nesbitt-Miller, Alexis F. Turgeon, Benoit Bailey, Diane P. Calello, Ryan Chuang, Theodore C. Bania, Bruno Mégarbane, Ashish Bhalla & Valéry Lavergne. (2016) Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning. Clinical Toxicology 54:10, pages 899-923.
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Sophie Gosselin, Lotte C. Hoegberg, Bryan D. Hayes, Marc Ghannoum, Robert S. Hoffman, Chibuzo Odigwe, Madiha Tariq, Kizito C. Ojiako & Nkem A. Iroegbu. (2016) Reader Comments. Baylor University Medical Center Proceedings 29:4, pages 444-445.
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