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ArticlesCritical Care

Tramadol overdose as a cause of serotonin syndrome: a case series

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Pages 337-341 | Received 13 Nov 2009, Accepted 17 Feb 2010, Published online: 05 Apr 2010

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Tarek Soliman, Hussein Shaher, Ahmed Mohey, Waleed El-Shaer & Ahmed Sebaey. (2022) Gonadotoxic effect of tramadol administration: A prospective controlled study. Arab Journal of Urology 20:1, pages 54-60.
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Camille Lagard, Isabelle Malissin, Wassila Indja, Patricia Risède, Lucie Chevillard & Bruno Mégarbane. (2018) Is naloxone the best antidote to reverse tramadol-induced neuro-respiratory toxicity in overdose? An experimental investigation in the rat. Clinical Toxicology 56:8, pages 737-743.
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Ahmed Amin Ali, Mahmoud Mohamed Abdeshafy, Khaled Abdelkawy, Ramy M. Elsabaa & Fawzy Elbarbry. (2023) Clinical and Laboratory Factors Related to Seizure and Serotonin Toxicity in Tramadol Intoxication: An Egyptian Study. Clinical Drug Investigation 43:12, pages 963-971.
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Alireza Amanollahi, Yadollah Mehrabi, Mohsen Sedighi, Hamed Basir Ghafouri, Amir Zahedi, Shahin Shadnia & Koorosh Etemad. (2023) Assessment of renal function indexes in methamphetamine or tramadol intoxication adults to the emergency departments: a systematic review and meta-analysis. BMC Emergency Medicine 23:1.
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Aliasghar Manouchehri, Zahra Nekoukar, Abdollah Malakian & Zakaria Zakariaei. (2023) Tramadol poisoning and its management and complications: a scoping review. Annals of Medicine & Surgery 85:8, pages 3982-3989.
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Anthony Spadaro, Kevin R. Scott, Alex Koyfman & Brit Long. (2022) High risk and low prevalence diseases: Serotonin syndrome. The American Journal of Emergency Medicine 61, pages 90-97.
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Camille Lagard, Dominique Vodovar, Lucie Chevillard, Jacques Callebert, Fabien Caillé, Géraldine Pottier, Hao Liang, Patricia Risède, Nicolas Tournier & Bruno Mégarbane. (2022) Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat. Pharmaceuticals 15:10, pages 1254.
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Ali Reza Fakhari, Seyedeh Mahsa Safavi, Ardeshir D. Yeganeh, Mostafa M. Amini & Ali Sahragard. (2022) Application of amine-functionalized mesostructured cellular foam assisted electromembrane extraction for the determination of tramadol and methadone from urine samples. Journal of the Iranian Chemical Society 19:8, pages 3431-3440.
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Olaf H. Drummer, Dimitri Gerostamoulos & Jennifer L. Schumann. 2022. Handbook of Forensic Medicine. Handbook of Forensic Medicine 1099 1105 .
Leila Mohammadnejad, Kambiz Soltaninejad, Mohammad Seyedabadi, Seyed Khosro Ghasem Pouri, Mohammad Shokrzadeh & Hamidreza Mohammadi. (2021) Evaluation of mitochondrial dysfunction due to oxidative stress in therapeutic, toxic and lethal concentrations of tramadol. Toxicology Research 10:6, pages 1162-1170.
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Nadia Fathy Hassabou & Mohamed M. Elseweidy. (2021) Histopathological changes in submandibular gland and dorsal tongue of experimental rats due to prolonged tramadol intake focusing on novel modulatory effect of 10-dehydrogingerdione. Archives of Oral Biology 130, pages 105223.
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Saud Alrashdi, Vibhu Paudyal, Mohamed Hassan Elnaem & Ejaz Cheema. (2021) Causes, Nature and Toxicology of Tramadol-Associated Deaths Reported in the Peer-Reviewed Literature: A Systematic Review of Case Studies and Case Series. Drugs & Therapy Perspectives 37:9, pages 422-432.
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Samaneh Nakhaee, Christopher Hoyte, Richard C. Dart, Masoumeh Askari, Roland J. Lamarine & Omid Mehrpour. (2021) A review on tramadol toxicity: mechanism of action, clinical presentation, and treatment. Forensic Toxicology 39:2, pages 293-310.
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Samaneh Nakhaee, Khadijeh Farrokhfall, Ebrahim Miri-Moghaddam, Mohsen Foadoddini, Masoumeh Askari, Alireza Amirabadizadeh, Jeffrey Brent, Bruno Megarbane & Omid Mehrpour. (2021) The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study. Behavioral and Brain Functions 17:1.
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PrasannaVenkatesh Ramesh, ShruthyVaishali Ramesh, Ramesh Rajasekaran & MeenaKumari Ramesh. (2021) Dangerous and deadly phenytoin-induced idiosyncratic mydriatic reaction in an epileptic patient precipitating a bilateral acute angle-closure attack. Indian Journal of Ophthalmology - Case Reports 1:3, pages 509.
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Laura M. Tormoehlen. 2021. Emergency Neurology. Emergency Neurology 373 401 .
Yasna Rostam‐Abadi, Jaleh Gholami, Masoumeh Amin‐Esmaeili, Anousheh Safarcherati, Ramin Mojtabai, Mohammad Reza Ghadirzadeh, Hosein Rahimi & Afarin Rahimi‐Movaghar. (2020) Tramadol use and public health consequences in Iran: a systematic review and meta‐analysis. Addiction 115:12, pages 2213-2242.
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Hyunji Koo, Min Taek Lee, Seung Hun You, Jeong Yeon Seon, Sieun Lee, Kyeong Hye Jeong & Sun‐Young Jung. (2019) Duplicated tramadol use in chronic low back pain: A nationwide cross‐sectional study. Basic & Clinical Pharmacology & Toxicology 126:3, pages 226-235.
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Abdelmoty Kabbash, Rabab El Kelany, Merfat Oreby & Dina El Gameel. (2019) Effect of tramadol dependence on male sexual dysfunction. Interdisciplinary Toxicology 12:4, pages 157-162.
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Nastaran Eizadi-Mood, Maliheh Ghandehari, Marjan Mansourian, AliMohammad Sabzghabaee, Shiva Samasamshariat & Erfan Sadeghi. (2019) Risk of seizure after naloxone therapy in acute tramadol poisoning: A systematic review with meta-analysis. International Journal of Preventive Medicine 10:1, pages 183.
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T. M. Ostroumova, O. D. Ostroumova, E. S. Akimova & A. I. Kochetkov. (2019) Drug-induced seizures: prevalence, risk factors, treatment and prevention. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 119:11, pages 86.
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Anis Mahmoud, Fatma Abid, Imen Ksiaa, Sourour Zina, Riadh Messaoud & Moncef Khairallah. (2018) Bilateral acute angle-closure glaucoma following tramadol subcutaneous administration. BMC Ophthalmology 18:1.
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Sameer Hassamal, Karen Miotto, William Dale & Itai Danovitch. (2018) Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures. The American Journal of Medicine 131:11, pages 1382.e1-1382.e6.
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Mugtaba Osman & Mashael Mustafa. (2018) Tramadol-Induced Mood Elevation in a Patient with No Previous Psychiatric History. Case Reports in Psychiatry 2018, pages 1-3.
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Brian A. Baldo. (2018) Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects. Archives of Toxicology 92:8, pages 2457-2473.
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Arnold YL Wong, Jaro Karppinen & Dino Samartzis. (2017) Low back pain in older adults: risk factors, management options and future directions. Scoliosis and Spinal Disorders 12:1.
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Nicolas Belin, Anne-Laure Clairet, Sidney Chocron, Gilles Capellier & Gaël Piton. (2016) Refractory Cardiogenic Shock During Tramadol Poisoning: A Case Report. Cardiovascular Toxicology 17:2, pages 219-222.
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Fares Najari, Anahita Alizadeh-Ghamsari, Maryam Vahabzadeh, Bita Dadpour, Seyed Reza Mousavi & Ideh Baradaran Kayal. (2017) A Study of the Importance of Clonus Symptoms in Patients with Tramadol Poisoning. Journal of Toxicology 2017, pages 1-4.
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Scott Lucyk & Lewis S. Nelson. 2017. Critical Care Toxicology. Critical Care Toxicology 1237 1249 .
Peyman Hafezi Moghadam, Najmeh Zarei, Davood Farsi, Saeed Abbasi, Mani Mofidi, Mahdi Rezai & Babak Mahshidfar. (2016) Electrocardiographic changes in patients with tramadol-induced idiosyncratic seizures. Turkish Journal of Emergency Medicine 16:4, pages 151-154.
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Camille Lagard, Lucie Chevillard, Isabelle Malissin, Patricia Risède, Jacques Callebert, Laurence Labat, Jean-Marie Launay, Jean-Louis Laplanche & Bruno Mégarbane. (2016) Mechanisms of tramadol-related neurotoxicity in the rat: Does diazepam/tramadol combination play a worsening role in overdose?. Toxicology and Applied Pharmacology 310, pages 108-119.
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Meredith R. Brooks & Brenda Golianu. (2016) Perioperative management in children with chronic pain. Pediatric Anesthesia 26:8, pages 794-806.
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Hossein Ansari & Leila Kouti. (2016) Drug Interaction and Serotonin Toxicity with Opioid Use: Another Reason to Avoid Opioids in Headache and Migraine Treatment. Current Pain and Headache Reports 20:8.
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Ibrahim A. Abdel-Hamid, Karl-Erik Andersson, Marcel D. Waldinger & Tarek H. Anis. (2016) Tramadol Abuse and Sexual Function. Sexual Medicine Reviews 4:3, pages 235-246.
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Bruno Mégarbane. (2016) Overdose aux opioïdes : présentation clinique et place de la naloxone. Bulletin de l'Académie Nationale de Médecine 200:4-5, pages 843-856.
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Mina Maher Mikhail Rizk, Ahmed Mohamed Kamal, Mohamed Ayman Abdelhameed Bakheet, Nashaat Adel Mohamed Abdelfadeel, Enas Mahmoud Hassan & Amal Tawfik Mohamed Khafagi. (2016) Frequency and Factors Associated With Occurrence of Seizures in Patients With Tramadol Abuse. Addictive Disorders & Their Treatment 15:1, pages 42-48.
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Adam R. Bosak & Aaron B. Skolnik. (2014) Serotonin Syndrome Associated with Metaxalone Overdose. Journal of Medical Toxicology 10:4, pages 402-405.
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Yenny Indrawirawan & Trudi McAlees. (2014) Tramadol toxicity in a cat: case report and literature review of serotonin syndrome. Journal of Feline Medicine and Surgery 16:7, pages 572-578.
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Hossein Sanaei-Zadeh. (2013) Is prophylactic administration of the anticonvulsants necessary in tramadol-intoxicated patients after an initial seizure?. DARU Journal of Pharmaceutical Sciences 21:1.
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Hamid Khosrojerdi, Reza Afshari & Omid Mehrpour. (2013) Should activated charcoal be given after tramadol overdose?. DARU Journal of Pharmaceutical Sciences 21:1.
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Chiara Angeletti, Cristiana Guetti, Antonella Paladini & Giustino Varrassi. (2013) Tramadol Extended-Release for the Management of Pain due to Osteoarthritis. ISRN Pain 2013, pages 1-16.
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