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Clinical Toxicology Volume 17, 1980 - Issue 3
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Research Article

Chloramphenicol Toxicity: Pathogenetic Mechanisms and the Role of the p-NO2 in Aplastic Anemia

Adel A. Yunis Departments of Medicine, Biochemistry, and Oncology, University of Miami School of Medicine; Howard Hughes Medical Institute, Miami, Florida, 33101
,
Alan M. Miller Departments of Medicine, Biochemistry, and Oncology, University of Miami School of Medicine; Howard Hughes Medical Institute, Miami, Florida, 33101
,
Ziad Salem Departments of Medicine, Biochemistry, and Oncology, University of Miami School of Medicine; Howard Hughes Medical Institute, Miami, Florida, 33101
&
Grace K. Arimura Departments of Medicine, Biochemistry, and Oncology, University of Miami School of Medicine; Howard Hughes Medical Institute, Miami, Florida, 33101
Pages 359-373 | Published online: 25 Sep 2008

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Peter Jacobs & Nicolas Novitzky. (1996) Acquired Aplasia of the Bone Marrow. Hematology 1:1, pages 59-64.
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Georges F. Bories & Jean-Pierre Cravedi. (1994) Metabolism of Chloramphenicol: A Story of Nearly 50 Years. Drug Metabolism Reviews 26:4, pages 767-783.
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Articles from other publishers (39)

Alexis N. Edwards, Anthony J. Blue, Jessica M. Conforti, Michael S. Cordes, Michael A. Trakselis & Elyssia S. Gallagher. (2023) Gas-phase stability and thermodynamics of ligand-bound, binary complexes of chloramphenicol acetyltransferase reveal negative cooperativity. Analytical and Bioanalytical Chemistry.
Crossref
ALA F. NASSAR. 2022. Drug Metabolism Handbook. Drug Metabolism Handbook 345 372 .
Dafeng Lu, Taiwu Wang, Zhenghan Luo, Fuqiang Ye, Jiaojiao Qian, Jinhai Zhang & Chunhui Wang. (2022) Evaluation of the Therapeutic Effect of Antibiotics on Scrub Typhus: A Systematic Review and Network Meta-Analysis. Frontiers in Public Health 10.
Crossref
Smita PattanaikArihant Jain & Jasmina Ahluwalia. (2021) Evolving Role of Pharmacogenetic Biomarkers to Predict Drug-Induced Hematological Disorders. Therapeutic Drug Monitoring 43:2, pages 201-220.
Crossref
Mintong Yu, Tian Xia, Wanchen Bai, Jinyu Ji, Huan Wang, Yaqi Huang, Shengyuan Deng, Kefeng Ma, Yan Su & Ying Wan. (2020) Handheld Aptasensor for Sandwiched Detection of Chloramphenicol. Chemical Research in Chinese Universities 36:2, pages 291-295.
Crossref
Lorenzo. (2019) Chloramphenicol Resurrected: A Journey from Antibiotic Resistance in Eye Infections to Biofilm and Ocular Microbiota. Microorganisms 7:9, pages 278.
Crossref
. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 836 840 .
. (2014) Scientific Opinion on Chloramphenicol in food and feed. EFSA Journal 12:11.
Crossref
Ala F. Nassar. 2010. Biotransformation and Metabolite Elucidation of Xenobiotics. Biotransformation and Metabolite Elucidation of Xenobiotics 163 216 .
Ala F. Nassar. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 24 .
Ala F. Nassar. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 13 .
D. Parent-Massin, N. Hymery & Y. Sibiril. (2010) Stem cells in myelotoxicity. Toxicology 267:1-3, pages 112-117.
Crossref
. 2010. Meyler's Side Effects of Antimicrobial Drugs. Meyler's Side Effects of Antimicrobial Drugs 1 443 .
Silvia Regina Rocha Siqueira, José Luiz Donato, Gilberto de Nucci & Felix Guillermo Reyes Reyes. (2010) A high‐throughput method for determining chloramphenicol residues in poultry, egg, shrimp, fish, swine and bovine using LC‐ESI‐MS/MS. Journal of Separation Science 32:23-24, pages 4012-4019.
Crossref
Ala F. Nassar. 2009. Drug Metabolism Handbook. Drug Metabolism Handbook 283 306 .
Curtis Wright IV, Sidney Schnoll & David Bernstein. (2008) Risk Evaluation and Mitigation Strategies for Drugs with Abuse Liability. Annals of the New York Academy of Sciences 1141:1, pages 284-303.
Crossref
. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 3373 3375 .
A.K. Nyarko, L.K.N. Okine, R.K. Wedzi, P.A. Addo & M. Ofosuhene. (2005) Subchronic toxicity studies of the antidiabetic herbal preparation ADD-199 in the rat: absence of organ toxicity and modulation of cytochrome P450. Journal of Ethnopharmacology 97:2, pages 319-325.
Crossref
Alaa-Eldin F. Nassar, Amin M. Kamel & Caroline Clarimont. (2004) Improvingthe decision-making process in structural modification of drug candidates: reducing toxicity. Drug Discovery Today 9:24, pages 1055-1064.
Crossref
J.A Turton, C.M Andrews, A.C Havard, S Robinson, M York, T.C Williams & F.M Gibson. (2002) Haemotoxicity of thiamphenicol in the BALB/c mouse and Wistar Hanover rat. Food and Chemical Toxicology 40:12, pages 1849-1861.
Crossref
P Eyer. (1994) Reactions of oxidatively activated arylamines with thiols: reaction mechanisms and biologic implications. An overview.. Environmental Health Perspectives 102:suppl 6, pages 123-132.
Crossref
T. Midtvedt. 1992. 273 284 .
Carl W. Peterson. 1992. Applied Therapeutics. Applied Therapeutics 931 944 .
J.P. Cravedi & M. Baradat. (1991) Comparative metabolic profiling of chloramphenicol by isolated hepatocytes from rat and trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 100:3, pages 649-652.
Crossref
J.J. Jimenez, J.G. Jimenez, D. Daghistani & A.A. Yunis. (1990) Interaction of Chloramphenicol and Metabolites with Colony Stimulating Factors: Possible Role in Chloramphenicol-Induced Bone Marrow Injury. The American Journal of the Medical Sciences 300:6, pages 350-353.
Crossref
Catherine Nissen-Druey. (1989) 3 Pathophysiology of aplastic anaemia. Bailli?re's Clinical Haematology 2:1, pages 37-49.
Crossref
E.C. Gordon-Smith. (1989) 1 Aplastic anaemia?aetiology and clinical features. Bailli?re's Clinical Haematology 2:1, pages 1-18.
Crossref
Mike Isildar, Wafa H. Abou-Khalil, Joaquin J. Jimenez, Samir Abou-Khalil & Adel A. Yunis. (1988) Aerobic nitroreduction of dehydrochloramphenicol by bone marrow. Toxicology and Applied Pharmacology 94:2, pages 305-310.
Crossref
Mike Isildar, Joaquin J. Jimenez, Grace K. Arimura & Adel A. Yunis. (2006) DNA damage in intact cells induced by bacterial metabolites of chloramphenicol. American Journal of Hematology 28:1, pages 40-46.
Crossref
Craig G. Schilling, Tom A. Larson & Donald L. Uden. (2016) Chloramphenicol-Associated Aplastic Anemia. Journal of Pharmacy Technology 4:2, pages 54-59.
Crossref
Lorraine E. Twerdok & Michael A. Trush. (1988) Neutrophil-derived oxidants as mediators of chemical activation in bone marrow. Chemico-Biological Interactions 65:3, pages 261-273.
Crossref
Steve Teo, Lance Pohl & James Halpert. (1986) Production of superoxide anion radicals during the oxidative metabolism of aminochloramphenicol. Biochemical Pharmacology 35:24, pages 4584-4586.
Crossref
Frank W. Besamusca & Louis A. Bastiaensen. (1986) Blood dyscrasias and topically applied chloramphenicol in ophthalmology. Documenta Ophthalmologica 64:1, pages 87-95.
Crossref
P. C. Vincent. (1984) In vitro evidence of drug action in aplastic anemia. Blut 49:1, pages 3-12.
Crossref
E. Baumelou & Y. Najean. (1983) Why still prescribe chloramphenicol in 1983?. Blut 47:6, pages 317-320.
Crossref
J M Wal, D E Corpet, J C Peleran & G F Bories. (1983) Comparative metabolism of chloramphenicol in germfree and conventional rats. Antimicrobial Agents and Chemotherapy 24:1, pages 89-94.
Crossref
Brion J. Gross, Richard V. Branchflower, Terrence R. Burke, David E. Lees & Lance R. Pohl. (1982) Bone marrow toxicity in vitro of chloramphenicol and its metabolites. Toxicology and Applied Pharmacology 64:3, pages 557-565.
Crossref
Thomas Murray, Kathleen M. Downey & Adel A. Yunis. (1982) Degradation of isolated deoxyribonucleic acid mediated by nitroso-chloramphenicol. Biochemical Pharmacology 31:13, pages 2291-2296.
Crossref
T. Midtvedt. 1982. 247 252 .

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