94
Views
41
CrossRef citations to date
0
Altmetric
Research Article

Chloramphenicol Toxicity: Pathogenetic Mechanisms and the Role of the p-NO2 in Aplastic Anemia

, , &
Pages 359-373 | Published online: 25 Sep 2008

References

  • Yunis A. A., Bloomberg G. R. Chloramphenicol toxicity: Clinical features and pathogenesis. Prog. Hematol. 1964; 4: 138
  • Martelo O. J., Manyan D. R., Smith U. S., Yunis A. A. Chloramphenicol and bone marrow mitochondria. J. Lab. Clin. Med. 1969; 74: 927
  • Smith U., Smith D., Yunis A. A. Chloramphenicol‐related changes in mitochondria ultrastructure. J. Cell Sci. 1970; 7: 501
  • Yunis A. A., Smith U. S., Restrepo A. Reversible bone marrow suppression from chloramphenicol. Arch. Intern. Med. 1970; 126: 272
  • Yunis A. Mechanisms underlying marrow toxicity from chloramphenicol and thiamphenicol. The Year of Hematology, R. Silber, J. LoBue, A. Gordon. Plenum, New York 1978; 143
  • Manyan D. R., Yunis A. A. The effect of chloramphenicol treatment on ferrochelatase activity in dogs. Biochem. Biophys. Res. Commun. 1970; 41: 926
  • Manyan D. R., Arimura G. K., Yunis A. A. Chlorampheni‐col‐induced erythroid suppression and bone marrow ferrochelatase activity in dogs. J. Lab. Clin. Med. 1972; 79: 137
  • Firkin F. C., Linnane A. W. Differential effects of chloramphenicol on the growth and respiration of mammalian cells. Biochem. Biophys. Res. Commun. 1968; 32: 398
  • Bradley T. R., Metcalf D. The growth of mouse marrow cells in vitro. Aust. J. Exp. Biol. Med. Sci. 1966; 44: 287
  • Ratzan R. J., Moore M. A. S., Yunis A. A. Effect of chloramphenicol on the in vitro colony forming cell. Blood 1974; 43: 363
  • Yunis A. A., Gross M. A. Drug‐induced inhibitions of myeloid colony growth: Protective effect of colony stimulating factor. J. Lab. Clin. Med. 1975; 86: 499
  • Yunis A. A., Adamson J. W. Differential in vitro sensitivity of marrow erythroid and granulocytic colony forming cells to chloramphenicol. Am. J. Hematol. 1977; 2: 355
  • Miller A. M., Arimura G. K., Gross M. A., Yunis A. A. In vitro evidence for genetically determined variations in marrow erythroid cell sensitivity to chloramphenicol. Exp. Hematol. (Copenhagen) 1978; 6: 455
  • Keiser G. Co‐operative study of patients treated with thiam‐phenicol. Comparative study of patients treated with chloramphenicol and thiamphenicol. Postgrad. Med. J. 1974; 50: 143
  • Yunis A. A. Pathogenetic Mechanisms in Bone Marrow Suppression from Chloramphenicol and Thiamphenicol. Presented at the Symposium on Aplastic Anemia, KyotoJapan, 1976
  • Yunis A. A., Manyan D. R., Arimura G. K. Comparative effect of chloramphenicol and thiamphenicol on DNA and mitochondrial protein synthesis in mammalian cells. J. Lab. Clin. Med. 1973; 81: 713
  • Yunis A. A., Manyan D. R., Arimura G. K. Comparative metabolic effects of chloramphenicol and thiamphenicol in mammalian cells. Postgrad. Med. J. 1974; 50: 50
  • Freeman K. B., Hasmukh P., Haldar D. Inhibition of DNA synthesis in Erhlich ascites cells by chloramphenicol. Mol. Pharmacol. 1977; 13: 504
  • Manyan D. R., Arimura G. K., Yunis A. A. Comparative metabolic effects of chloramphenicol analogues. Mol. Pharmacol. 1975; 11: 520
  • Corbett M. D., Chipko B. R. Synthesis and antibiotic properties of chloramphenicol reduction products. Antimicrob. Agents Chemother. 1978; 13: 193
  • Yunis A. A., Arimura G. K., Haines H. G., Ratzan R. J., Gross M. A. Characteristics of rat chloroma in culture. Cancer Res. 1975; 35: 337
  • McCulloch E. A., Till J. E. The radiation sensitivity of normal mouse bone marrow cells as determined by quantitative marrow transplantation into irradiated mice. Radiat. Res. 1960; 13: 115
  • Tobey R. A., Crissman H. H. Comparative effects of three nitrosourea derivatives on mammalian cell cycle progression. Cancer Res. 1975; 35: 46
  • Yunis A. A., Harrington J. W. Patterns of inhibition by chloramphenicol of nucleic acid synthesis in human bone marrow and leukemic leukocytes. J. Lab. Clin. Med. 1960; 56: 831
  • Yunis A. A., Arimura G. K. Biochemical predisposition to chloramphenicol‐induced bone marrow aplasia. Clin. Res. 1963; 11: 201
  • Yunis A. A. Drug‐induced bone marrow injury. Adv. Intern. Med. 1969a; 15: 347
  • Nago T., Mauer A. M. Concordance for drug‐induced aplastic anemia in identical twins. N. Engl. J. Med. 1969; 281: 11
  • Dulbecco R. Report on a discussion meeting on the biology of chemical carcinogensis. Proc. R. Soc. London 1977; 196: 117
  • Hamburger R. N. Chloramphenicol‐specific antibody. Science 1966; 152: 203
  • Schultz D. R., Walling J. S., Yunis A. A. Chloramphenicol‐induced humoral and cellular responses in rabbits and man. Clin. Res. 1979
  • Schultz D. R., Walling J. S., Yunis A. A. Evidence for an immune mechanism in chloramphenicol‐induced aplastic anemia. Clin. Res. 1979; 24: 464A
  • Fonts J. R., Brodie B. B. The enzymatic reduction of chloramphenicol, p‐nitrobenzoic acid, and other aromatic nitro compounds in mammals. J. Pharm. Exp. Ther. 1957; 119: 197
  • Juchau M. R. Studies on the reduction of aromatic nitro groups in human and rodent placental homogenates. J. Pharmacol. Exp. Ther. 1969; 165: 1
  • Salem Z., Yunis A. A. The reduction of chloramphenicol and paranitrobenzoic acid by human liver homogenates, To be published
  • Wang C. Y., Chin C. W., Bryan G. T. Nitroreduction of carcinogenic 5‐nitrothiophenes by rat tissues. Biochem. Pharmacol. 1968; 24: 1563
  • Speck W. T., Stein A. B., Rosenkranz H. S. Mutagenicity of metronidazole: Presence of several active metabolites in human urine. J. Natl. Cancer Inst. 1976; 56: 283

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.