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Research Article

Ethylene Glycol Poisoning. The Value of Glycolic Acid Determinations for Diagnosis and Treatment

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Pages 389-402 | Published online: 25 Sep 2008

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Darren M. Roberts, Robert S. Hoffman, Jeffrey Brent, Valéry Lavergne, Knut Erik Hovda, William H. Porter, Kenneth E. McMartin & Marc Ghannoum. (2022) The serum glycolate concentration: its prognostic value and its correlation to surrogate markers in ethylene glycol exposures. Clinical Toxicology 60:7, pages 798-807.
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Jessie Beaulieu, Darren M. Roberts, Sophie Gosselin, Robert S. Hoffman, Valery Lavergne, Knut Erik Hovda, Bruno Megarbane, Derrick Lung, Ruben Thanacoody & Marc Ghannoum. (2022) Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review. Clinical Toxicology 60:7, pages 784-797.
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Knut Erik Hovda, Joar Julsrud, Steinar ØvrebØ, Odd BrØrs & Dag Jacobsen. (2011) Studies on ethylene glycol poisoning: One patient – 154 admissions. Clinical Toxicology 49:6, pages 478-484.
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The American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning:Donald G. Barceloux, G. Randall Bond, Edward P. Krenzelok, Hannah Cooper & J. Allister Vale. (2002) American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning. Journal of Toxicology: Clinical Toxicology 40:4, pages 415-446.
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William H. Porter, Philip W. Rutter, Barbara A. Bush, Alex A. Pappas & James E. Dunnington. (2001) Ethylene Glycol Toxicity: The Role of Serum Glycolic Acid In Hemodialysis. Journal of Toxicology: Clinical Toxicology 39:6, pages 607-615.
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Heather Miller, Donald G. Barceloux, Edward P. Krenzelok, Kent Olson & William Watson. (1999) American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Journal of Toxicology: Clinical Toxicology 37:5, pages 537-560.
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Christina L. Moreau, William Kerns, Christian A. Tomaszewski, Kenneth E. McMartin, S. Ruddy Rose, Marsha D. Ford & Jeffrey Brent. (1998) Glycolate Kinetics and Hemodialysis Clearance in Ethylene Glycol Poisoning. Journal of Toxicology: Clinical Toxicology 36:7, pages 659-666.
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Dag Jacobsen & Kenneth E. McMartin. (1997) Antidotes for Methanol and Ethylene Glycol Poisoning. Journal of Toxicology: Clinical Toxicology 35:2, pages 127-143.
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G. L. Kennedy & B. A. Burgess. (1997) INHALATION TOXICOLOGY OF GLYCOLIC ACID. Inhalation Toxicology 9:5, pages 435-447.
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Eric A. De Leacy, Leith N. Moxon, Vivienne M. Ellis, Jack M.A.M. Van Dongen, Leslie P. Johnson, David M. Doddrell & David M. Cowley. (1995) A report of accidental ethylene glycol ingestion in 2 siblings. Pathology 27:3, pages 273-276.
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Albert D. Fraser & Wallace Macneil. (1993) Colorimetric and Gas Chromatographic Procedures for Glycolic Acid in Serum: The Major Toxic Metabolite of Ethylene Glycol. Journal of Toxicology: Clinical Toxicology 31:3, pages 397-405.
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Hans-Olof Malmlund, Anders Berg, Gunnar Karlman, Anita Magnusson & Bengt Ullman. (1991) considerations for the treatment of Ethylene glycol poisoning Based On Analysis Of Two Cases. Journal of Toxicology: Clinical Toxicology 29:2, pages 231-240.
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Articles from other publishers (41)

Marc Ghannoum, Sophie Gosselin, Robert S. Hoffman, Valery Lavergne, Bruno Mégarbane, Hossein Hassanian-Moghaddam, Maria Rif, Siba Kallab, Steven Bird, David M. Wood, Darren M. Roberts, Badria Alhatali, Kurt Anseeuw, Ingrid Berling, Josée Bouchard, Timothy E. Bunchman, Diane P. Calello, Paul K. Chin, Kent Doi, Tais Galvao, David S. Goldfarb, Lotte C. G. Hoegberg, Sofia Kebede, Jan T. Kielstein, Andrew Lewington, Yi Li, Etienne M. Macedo, Rob MacLaren, James B. Mowry, Thomas D. Nolin, Marlies Ostermann, Ai Peng, Jean-Philippe Roy, Greene Shepherd, Anitha Vijayan, Steven J. Walsh, Anselm Wong & Christopher Yates. (2023) Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup. Critical Care 27:1.
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Pouria Jarsiah, Joerg Roehrich, Marek Wyczynski & Cornelius Hess. (2020) Phase I metabolites (organic acids) of gamma‐hydroxybutyric acid–validated quantification using GC–MS and description of endogenous concentration ranges. Drug Testing and Analysis 12:8, pages 1135-1143.
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Víctor Pérez Medina Martínez, Carlos Eduardo Espinosa de la Garza, Antonio Germán Hernández-García & Néstor O. Pérez. (2020) Detection and quantification of leached ethylene glycol in biopharmaceuticals by RP-UHPLC. Analytical and Bioanalytical Chemistry 412:8, pages 1795-1806.
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Uttam Garg & Hema Ketha. 2020. Toxicology Cases for the Clinical and Forensic Laboratory. Toxicology Cases for the Clinical and Forensic Laboratory 37 49 .
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Ivan N. Co & Kyle J. Gunnerson. 2019. Critical Care Nephrology. Critical Care Nephrology 417 423.e2 .
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Gaspar Tuero, Jesús González, Laura Sahuquillo, Anna Freixa, Isabel Gomila, Miguel Ángel Elorza & Bernardino Barceló. (2018) Value of glycolic acid analysis in ethylene glycol poisoning: A clinical case report and systematic review of the literature. Forensic Science International 290, pages e9-e14.
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Knut Erik Hovda, Kenneth McMartin & Dag Jacobsen. 2017. Critical Care Toxicology. Critical Care Toxicology 1743 1760 .
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Tomáš Hložek, Miroslava Bursová & Radomír Čabala. (2014) Fast determination of ethylene glycol, 1,2-propylene glycol and glycolic acid in blood serum and urine for emergency and clinical toxicology by GC-FID. Talanta 130, pages 470-474.
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Sally L. Hanton & Ian D. Watson. (2013) An Enzymatic Assay for the Detection of Glycolic Acid in Serum as a Marker of Ethylene Glycol Poisoning. Therapeutic Drug Monitoring 35:6, pages 836-843.
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William M. Snellings, Richard A. Corley, Kenneth E. McMartin, Christopher R. Kirman & Sol M. Bobst. (2013) Oral Reference Dose for ethylene glycol based on oxalate crystal-induced renal tubule degeneration as the critical effect. Regulatory Toxicology and Pharmacology 65:2, pages 229-241.
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Lorri Beatty, Robert Green, Kirk Magee & Peter Zed. (2013) A Systematic Review of Ethanol and Fomepizole Use in Toxic Alcohol Ingestions. Emergency Medicine International 2013, pages 1-14.
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Koen Poesen, Simon Degandt, Juul Boes, Florent Vanstapel, Koen Desmet & Pieter Vermeersch. (2012) Interference of ethylene glycol with lactate measurement: A comparison study on new generation cassette-based blood gas analyzers. Clinica Chimica Acta 414, pages 18-19.
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James A. Kruse. (2012) Methanol and Ethylene Glycol Intoxication. Critical Care Clinics 28:4, pages 661-711.
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