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Journal of Toxicology: Clinical Toxicology Volume 30, 1992 - Issue 2
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Research Article

Cerebral edema following acute sodium valproate overdose

S. H. Khoo Northwick Park Hospital, United Kingdom
&
M. J. Leyland East Birmingham Hospital, United Kingdom
Pages 209-214 | Published online: 25 Sep 2008

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Read on this site (8)

Philippe E.R. Lheureux & Philippe Hantson. (2009) Carnitine in the treatment of valproic acid-induced toxicity. Clinical Toxicology 47:2, pages 101-111.
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Anthony S. Manoguerra, Andrew R. Erdman, Alan D. Woolf, Peter A. Chyka, E. Martin Caravati, Elizabeth J. Scharman, Lisa L. Booze, Gwenn Christianson, Lewis S. Nelson, Daniel J. Cobaugh & William G. Troutman. (2008) Valproic acid poisoning: An evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology 46:7, pages 661-676.
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Matthew D. Sztajnkrycer. (2002) Valproic Acid Toxicity: Overview and Management. Journal of Toxicology: Clinical Toxicology 40:6, pages 789-801.
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Henry A. Spiller, Henry Spiller, Edward P. Krenzelok, Wendy Klein-Schwartz, Mark L. Winter, Julie A. Weber, Dawn R. Sollee & Stacy A. Bangh. (2000) Multicenter Case Series of Valproic Acid Ingestion: Serum Concentrations and Toxicity. Journal of Toxicology: Clinical Toxicology 38:7, pages 755-760.
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F PERTOLDI, L D'ORLANDO, S GALLIAZZO & W P MERCANTE. (1997) Haemodialysis in the management of severe valproic acid overdose. Clinical Intensive Care 8:5, pages 244-246.
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Andis Graudins & Cynthia K. Aaron. (1996) Delayed Peak Serum Valproic Acid in Massive Divalproex Overdose—Treatment with Charcoal Hemoperfusion. Journal of Toxicology: Clinical Toxicology 34:3, pages 335-341.
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Geir O. Andersen & Stale Ritland. (1995) Life Threatening Intoxication with Sodium Valproate. Journal of Toxicology: Clinical Toxicology 33:3, pages 279-284.
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Hans Persson. (1992) European association of poison centres and clinical toxicologists. Journal of Toxicology: Clinical Toxicology 30:2, pages v-vii.
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Articles from other publishers (22)

Gautham Pavar, Nicole Xu, Kinan Sawar, Vichar Trivedi & Diane L Levine. (2023) Valproate-Induced Encephalopathy Presenting at Therapeutic Blood Concentrations: A Case Report and Literature Review. Cureus.
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Shyam Kiran Gandam Venkata, Kenneth Guillotte, BreeAnna Murphy, Sai Sruthi Bhuram & Sudeep Chakravarthy Bhuram. (2021) Rapid Rescue From Hyperammonemic Coma After Valproic Acid Poisoning: Dual Therapy With Continuous Renal Replacement Therapy and L-Carnitine Supplementation. Cureus.
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Raghavendra Sanivarapu, Robin Sharma & Jagadish Akella. (2021) Thinking out of the box: management of valproic acid toxicity with carbapenems. BMJ Case Reports 14:3, pages e240140.
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Hristelina S. Ilieva, Joseph W. Newman, Ronald K. Fields & John E. Croom. (2020) Valproic acid and zonisamide induced hyperammonemic encephalopathy. Clinical Neurology and Neurosurgery 196, pages 105894.
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Allister Vale. (2016) Anticonvulsants. Medicine 44:3, pages 133-134.
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Dror Weiner, Vered Nir, Adi Klein-Kremer & Eiass Kassem. (2013) Chronic Valproic Acid Intoxication. Pediatric Emergency Care 29:6, pages 756-757.
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Matthew W. Hedge. (2012) Miscellaneous Central Nervous System Intoxicants. Critical Care Clinics 28:4, pages 587-600.
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Anna Grynnerup, Iv?n S?nchez Fern?ndez, Joan Calzada Hern?ndez, Angela Dey? Mart?nez, Jordi Muchart L?pez & Alfredo Garc?a-Alix. (2012) A Severe Valproate Overdose With Complete Recovery in a Newborn. Journal of Child Neurology 27:8, pages 1072-1076.
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Allister Vale. (2012) Anticonvulsants. Medicine 40:2, pages 96-97.
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Shuai-Ting Lin, Cheng-Sheng Chen, Cheng-Fang Yen, Jui-Hsiu Tsei & Shing-Yaw Wang. (2009) Valproate-related peripheral oedema: a manageable but probably neglected condition. The International Journal of Neuropsychopharmacology 12:07, pages 991.
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Evangelos Cholongitas, Chrysa Georgousaki, Simos Spyrou & Maria Dasenaki. (2009) Generalized convulsions due to sorafenib-induced hypocalcemia. Indian Journal of Gastroenterology 28:4, pages 158-159.
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Allister Vale. (2007) Anticonvulsants. Medicine 35:11, pages 585-586.
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Florian Eyer, Norbert Felgenhauer, Klaus Gempel, Werner Steimer, Klaus-Dieter Gerbitz & Thomas Zilker. (2005) Acute Valproate Poisoning. Journal of Clinical Psychopharmacology 25:4, pages 376-380.
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Philippe Hantson, C�cile Grandin, Thierry Duprez, Marie-C�cile Nassogne & Jean-Michel Gu�rit. (2004) Comparison of clinical, magnetic resonance and evoked potentials data in a case of valproic-acid-related hyperammonemic coma. European Radiology 15:1, pages 59-64.
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V Minville, C Roche Tissot & K Samii. (2004) Épuration extrarénale, supplémentation en L-carnitine et intoxication à l’acide valproïque. Annales Françaises d'Anesthésie et de Réanimation 23:4, pages 357-360.
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Geoffrey K. Isbister, Corrine R. Balit, Ian M. Whyte & Andrew Dawson. (2003) Valproate overdose: a comparative cohort study of self poisonings. British Journal of Clinical Pharmacology 55:4, pages 398-404.
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J. Field & F.S. Daly. (2002) Continuous Veno-Venous Haemodiafiltration in Sodium Valproate Overdose Complicated by Cerebral Oedema: A Case Report. Critical Care and Resuscitation 4:3, pages 173-176.
Crossref
Manish M. Patel, Ben T. Tsutaoka, Shireen Banerji, Paul D. Blanc & Kent R. Olson. (2002) ED utilization of computed tomography in a poisoned population. The American Journal of Emergency Medicine 20:3, pages 212-217.
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Richard D. Sanders. (2001) Valproate-related Edema. Clinical Neuropharmacology 24:2, pages 123-124.
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Sandra L Kane, Marigel Constantiner, Alfred E Staubus, Curt D Meinecke & John R Sedor. (2016) High-Flux Hemodialysis without Hemoperfusion is Effective in Acute Valproic Acid Overdose. Annals of Pharmacotherapy 34:10, pages 1146-1151.
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Jeffrey Reynold Brubacher, Payam Dahghani & Douglas McKnight. (1999) Delayed toxicity following ingestion of enteric-coated divalproex sodium (epival). The Journal of Emergency Medicine 17:3, pages 463-467.
Crossref
J Gordon Millichap. (1992) Valproate-Induced Cerebral Edema. Pediatric Neurology Briefs 6:9, pages 71.
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