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The World Journal of Biological Psychiatry Volume 4, 2003 - Issue 1
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Original Article

Testosterone Deficiency and Mood in Aging Men: Pathogenic and Therapeutic Interactions

Stuart N Seidman Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York; New York State Psychiatric Institute, New YorkCorrespondence[email protected]
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Pages 14-20 | Published online: 05 Aug 2009

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Shirin Amini, Sima Jafarirad & Behnaz Abiri. (2023) Vitamin D, testosterone and depression in middle-aged and elderly men: a systematic review. Critical Reviews in Food Science and Nutrition 63:21, pages 5194-5205.
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Jin-Hee Han, Mal-Soon Shin, Jae-Min Lee, Tae-Woon Kim, Jun-Jang Jin, Il-Gyu Ko, Sung-Eun Kim, Chang-Ju Kim, Mia Kim, Joo Hwan Roh & Khae Hawn Kim. (2018) Long-term chemical castration induces depressive symptoms by suppressing serotonin expression in rats. Animal Cells and Systems 22:1, pages 29-36.
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Engin Burak Selçuk, Lale Gönenir Erbay, Özlem Özel Özcan, Şükrü Kartalci & Kadir Batcioğlu. (2015) Testosterone levels of children with a diagnosis of developmental stuttering. Therapeutics and Clinical Risk Management 11, pages 793-798.
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Tom McNicholas & Teng Ong. (2006) Review of Testim® gel. Expert Opinion on Pharmacotherapy 7:4, pages 477-484.
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Articles from other publishers (51)

Shirin Amini, Houra Mohseni, Behnaz Abiri & Sima Jafarirad. (2023) The role of saffron ( Crocus sativus L) on testosterone and depression in andropause middle-aged and elderly men: a systematic review . Nutrition & Food Science 53:8, pages 1419-1436.
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Kayo Takahashi, Takamitsu Hosoya, Kayo Onoe, Tomoko Mori, Shusaku Tazawa, Aya Mawatari, Yasuhiro Wada, Yumiko Watanabe, Hisashi Doi & Yasuyoshi Watanabe. (2021) PET imaging of brain aromatase in humans and rhesus monkeys by 11C-labeled cetrozole analogs. Scientific Reports 11:1.
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Shubhadeep Roychoudhury, Saptaparna Chakraborty, Arun Paul Choudhury, Anandan Das, Niraj Kumar Jha, Petr Slama, Monika Nath, Peter Massanyi, Janne Ruokolainen & Kavindra Kumar Kesari. (2021) Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction. Antioxidants 10:6, pages 837.
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Dhruba Tara Maharjan, Ali Alamdar Shah Syed, Guan Ning Lin & Weihai Ying. (2021) Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study. Biomolecules 11:3, pages 409.
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O. O. Masalova, S. B. Kazakova, T. N. Savateeva-Lyubimova, K. V. Sivak, N. S. Sapronov & P. D. Shabanov. (2019) Effect of Surfagon on Open Field and Elevated Plus Maze Behavior of Gonadectomized and Non-Gonadectomized Male Rats. Bulletin of Experimental Biology and Medicine 168:1, pages 52-54.
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Zheng Chen, Quan Zhang, Shenghuo Chen, Weiwen Wang, Guoxiong Liu & Huihua Deng. (2019) Determination, intercorrelation and intraindividual stability of five steroids in hair, saliva and urine among chinese college students. Steroids 149, pages 108418.
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Hillary B. Nguyen, James Loughead, Emily Lipner, Liisa Hantsoo, Sara L. Kornfield & C. Neill Epperson. (2018) What has sex got to do with it? The role of hormones in the transgender brain. Neuropsychopharmacology 44:1, pages 22-37.
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Jennifer R. Rainville & Georgia E. Hodes. (2018) Inflaming sex differences in mood disorders. Neuropsychopharmacology 44:1, pages 184-199.
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Shalender Bhasin & Ravi Jasuja. 2019. Encyclopedia of Endocrine Diseases. Encyclopedia of Endocrine Diseases 721 734 .
Erik J. Giltay, Roos C. van der Mast, Esther Lauwen, Annemieke C. Heijboer, Margot W.M. de Waal & Hannie C. Comijs. (2017) Plasma Testosterone and the Course of Major Depressive Disorder in Older Men and Women. The American Journal of Geriatric Psychiatry 25:4, pages 425-437.
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Kumi Hirokawa, Toshiyo Taniguchi, Yasuhito Fujii, Jiro Takaki & Akizumi Tsutsumi. (2015) Modification Effects of Changes in Job Demands on Associations Between Changes in Testosterone Levels and Andropause Symptoms: 2-Year Follow-up Study in Male Middle-Aged Japanese Workers. International Journal of Behavioral Medicine 23:4, pages 464-472.
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Lee Ellis, Anthony Hoskin, Richard Hartley, Anthony Walsh, Alan Widmayer & Malini Ratnasingam. (2014) General Theory versus ENA Theory. International Journal of Offender Therapy and Comparative Criminology 59:13, pages 1429-1458.
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Shahla Khosravi, Hasan Eftekhar Ardebili, Bagher Larijani, Saharnaz Nedjat, Alireza Nikbakht Nasrabadi, Mehrdad Eftekhar Ardebili, Soheila Dabiran & Esmaeil Samizadeh. (2015) Are andropause symptoms related to depression?. Aging Clinical and Experimental Research 27:6, pages 813-820.
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Lale Gonenir Erbay, Ozlem Ozel Ozcan, Şükrü Kartalci, Tuğba Yüksel & Meryem Özlem Kütük. (2015) No evidence of androgenic neurosteroid involvement in pediatric OCD. Journal of Obsessive-Compulsive and Related Disorders 6, pages 97-100.
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Lale Gonenir ErbaySukru Kartalci. (2015) Neurosteroid Levels in Patients with Obsessive-Compulsive Disorder. Psychiatry Investigation 12:4, pages 538.
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Jeng-Rung Chen, Guo-Fang Tseng, Yueh-Jan Wang & Tsyr-Jiuan Wang. (2014) Exogenous dehydroisoandrosterone sulfate reverses the dendritic changes of the central neurons in aging male rats. Experimental Gerontology 57, pages 191-202.
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Şükrü Kumsar, Neslihan Akkişi Kumsar, Hasan Salih Sağlam, Osman Köse, Salih Budak & Öztuğ Adsan. (2014) Testosterone Levels and Sexual Function Disorders in Depressive Female Patients: Effects of Antidepressant Treatment. The Journal of Sexual Medicine 11:2, pages 529-535.
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Jeng-Rung Chen, Tsyr-Jiuan Wang, Seh-Hong Lim, Yueh-Jan Wang & Guo-Fang Tseng. (2013) Testosterone modulation of dendritic spines of somatosensory cortical pyramidal neurons. Brain Structure and Function 218:6, pages 1407-1417.
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Kumi Hirokawa, Toshiyo Taniguchi, Yasuhito Fujii, Jiro Takaki & Akizumi Tsutsumi. (2012) Job demands as a potential modifier of the association between testosterone deficiency and andropause symptoms in Japanese middle-aged workers: A cross-sectional study. Maturitas 73:3, pages 225-229.
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Hui Meng Tan, Seng Fah Tong & Christopher C.K. Ho. (2012) Men's Health: Sexual Dysfunction, Physical, and Psychological Health—Is There a Link?. The Journal of Sexual Medicine 9:3, pages 663-671.
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H. Bonilla-Jaime, O. Limón-Morales, M. Arteaga-Silva, M. Hernández-González, G. Guadarrama-Cruz, F. Alarcón-Aguilar & G. Vázquez-Palacios. (2010) Orchiectomy modifies the antidepressant-like response of nicotine in the forced swimming test. Physiology & Behavior 101:4, pages 456-461.
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Tibor Hajszan & Csaba Leranth. (2010) Bisphenol A interferes with synaptic remodeling. Frontiers in Neuroendocrinology 31:4, pages 519-530.
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Yuk Yee Yan. (2009) Awareness and Knowledge of Andropause Among Chinese Males in Hong Kong. American Journal of Men's Health 4:3, pages 231-236.
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Daehee Bak & Glenn Palmer. (2010) Testing the Biden Hypotheses: Leader Tenure, Age, and International Conflict. Foreign Policy Analysis 6:3, pages 257-273.
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M Ebinger, C Sievers, D Ivan, HJ Schneider & GK Stalla. (2008) Is there a neuroendocrinological rationale for testosterone as a therapeutic option in depression?. Journal of Psychopharmacology 23:7, pages 841-853.
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Fahd Aziz Zarrouf, Steven Artz, James Griffith, Cristian Sirbu & Martin Kommor. (2009) Testosterone and Depression. Journal of Psychiatric Practice 15:4, pages 289-305.
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Stuart N. Seidman, Guy Orr, Gil Raviv, Rachel Levi, Steven P. Roose, Efrat Kravitz, Revital Amiaz & Mark Weiser. (2009) Effects of Testosterone Replacement in Middle-Aged Men With Dysthymia. Journal of Clinical Psychopharmacology 29:3, pages 216-221.
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Cheryl A. Frye & Alicia A. Walf. (2009) Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites. Physiology & Behavior 97:2, pages 266-269.
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T.E. Buddenberg, M. Komorowski, L.A. Ruocco, M.A. de Souza Silva & B. Topic. (2009) Attenuating effects of testosterone on depressive-like behavior in the forced swim test in healthy male rats. Brain Research Bulletin 79:3-4, pages 182-186.
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Jinil Harvey & Judith A. Berry. (2009) Andropause in the Aging Male. The Journal for Nurse Practitioners 5:3, pages 207-212.
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Tibor Hajszan, Neil J. MacLusky & Csaba Leranth. (2008) Role of androgens and the androgen receptor in remodeling of spine synapses in limbic brain areas. Hormones and Behavior 53:5, pages 638-646.
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Gerhard Schreiber & Mirjana Ziemer. (2008) The aging male – diagnosis and therapy of late-onset hypogonadism. JDDG 6:4, pages 273-279.
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Cheryl A Frye, Kassandra Edinger & Kanako Sumida. (2007) Androgen Administration to Aged Male Mice Increases Anti-Anxiety Behavior and Enhances Cognitive Performance. Neuropsychopharmacology 33:5, pages 1049-1061.
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Heather B. Patisaul & Heather L. Bateman. (2008) Neonatal exposure to endocrine active compounds or an ERβ agonist increases adult anxiety and aggression in gonadally intact male rats. Hormones and Behavior 53:4, pages 580-588.
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Fuminobu ISHIKURA, Toshihiko ASANUMA & Shintaro BEPPU. (2008) Low Testosterone Levels in Patients with Mild Hypertension Recovered after Antidepressant Therapy in a Male Climacterium Clinic. Hypertension Research 31:2, pages 243-248.
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Mitsuko Yasuda, Kumiko Furuya, Takashi Yoshii, Hisamitu Ide, Satoru Muto & Shigeo Horie. (2007) Low testosterone level of middle-aged Japanese men – the association between low testosterone levels and quality-of-life. The Journal of Men's Health & Gender 4:2, pages 149-155.
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S N Seidman. (2006) Normative hypogonadism and depression: does ‘andropause’ exist?. International Journal of Impotence Research 18:5, pages 415-422.
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Stuart N SeidmanGuy Orr. (2006) Testosterone and mood in aging men. Aging Health 2:1, pages 61-69.
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Johanna L Hannan, Corry Smallegange, Taben M Hale, Jeremy PW Heaton & Michael A Adams. (2006) Impact of antihypertensive treatments on erectile responses in aging spontaneously hypertensive rats. Journal of Hypertension 24:1, pages 159-168.
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Stuart N. Seidman, Marissa Miyazaki & Steven P. Roose. (2005) Intramuscular Testosterone Supplementation to Selective Serotonin Reuptake Inhibitor in Treatment-Resistant Depressed Men. Journal of Clinical Psychopharmacology 25:6, pages 584-588.
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Michael Horowitz, Rose McDermott & Allan C. Stam. (2016) Leader Age, Regime Type, and Violent International Relations. Journal of Conflict Resolution 49:5, pages 661-685.
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Hermann M. Behre. (2005) Long-Term Morbidity of Late-Onset Hypogonadism. European Urology Supplements 4:6, pages 10-15.
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Kassandra L. Edinger & Cheryl A. Frye. (2005) Testosterone's anti-anxiety and analgesic effects may be due in part to actions of its 5α-reduced metabolites in the hippocampus. Psychoneuroendocrinology 30:5, pages 418-430.
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Tibor Hajszan, Neil J. MacLusky & Csaba Leranth. (2005) Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus. European Journal of Neuroscience 21:5, pages 1299-1303.
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T. U. Marron, V. Guerini, P. Rusmini, D. Sau, T. A. L. Brevini, L. Martini & A. Poletti. (2005) Androgen-induced neurite outgrowth is mediated by neuritin in motor neurones. Journal of Neurochemistry 92:1, pages 10-20.
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Min Jiang & Ilpo Huhtaniemi. (2004) Polymorphisms in androgen and estrogen receptor genes: effects on male aging. Experimental Gerontology 39:11-12, pages 1603-1611.
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Lucı́a Martı́nez-Mota & Alonso Fernández-Guasti. (2004) Testosterone-dependent antidepressant-like effect of noradrenergic but not of serotonergic drugs. Pharmacology Biochemistry and Behavior 78:4, pages 711-718.
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Susan Kaweski. (2004) Anti-Aging Medicine: Hormone Replacement Therapy in Men. Plastic and Reconstructive Surgery 113:5, pages 1506-1510.
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Arun Rajagopal, Rena Vassilopoulou‐Sellin, J. Lynn Palmer, Guddi Kaur & Eduardo Bruera. (2004) Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer 100:4, pages 851-858.
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Michael R Deschenes. (2004) Effects of Aging on Muscle Fibre Type and Size. Sports Medicine 34:12, pages 809-824.
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Kassandra L. Edinger & Cheryl A. Frye. (2004) Testosterone's Analgesic, Anxiolytic, and Cognitive-Enhancing Effects May Be Due in Part to Actions of Its 5α-Reduced Metabolites in the Hippocampus.. Behavioral Neuroscience 118:6, pages 1352-1364.
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