519
Views
48
CrossRef citations to date
0
Altmetric
REVIEW ARTICLE

Multiple levels of impaired neural plasticity and cellular resilience in bipolar disorder: Developing treatments using an integrated translational approach

, , , &
Pages 84-95 | Received 11 Mar 2013, Accepted 25 Jul 2013, Published online: 02 Sep 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Elena Milanesi, Roberta Zanardini, Gianluca Rosso, Giuseppe Maina, Alessandro Barbon, Cristina Mora, Alessandra Minelli, Massimo Gennarelli & Luisella Bocchio-Chiavetto. (2018) Insulin-like growth factor binding protein 2 in bipolar disorder: An expression study in peripheral tissues. The World Journal of Biological Psychiatry 19:8, pages 610-618.
Read now
Liliana Dell’Osso, Claudia Del Grande, Camilla Gesi, Claudia Carmassi & Laura Musetti. (2016) A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts. Neuropsychiatric Disease and Treatment 12, pages 1687-1703.
Read now

Articles from other publishers (46)

Rodrigo Machado-Vieira, Alan C. Courtes, Carlos A. ZarateJrJr, Ioline D. Henter & Husseini K. Manji. (2023) Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorder. Frontiers in Neuroscience 17.
Crossref
Kamilla W. Miskowiak, Anja H. Simonsen, Morten Meyer, Henrik Enghusen Poulsen, Mira Wilkan, Julie Forman, Steen G. Hasselbalch, Lars V. Kessing & Ulla Knorr. (2023) Cerebrospinal fluid erythropoietin, oxidative stress, and cognitive functions in patients with bipolar disorder and healthy control participants: A longitudinal case-control study. Journal of Psychiatric Research 163, pages 240-246.
Crossref
Fernanda Daniela Dornelas Nunes, Letícia Perticarrara Ferezin, Sherliane Carla Pereira, Fernanda Viana Figaro-Drumond, Lucas Cézar Pinheiro, Itiana Castro Menezes, Cristiane von Werne Baes, Fernanda Borchers Coeli-Lacchini, José Eduardo Tanus-Santos, Mário Francisco Juruena & Riccardo Lacchini. (2022) The Association of Biochemical and Genetic Biomarkers in VEGF Pathway with Depression. Pharmaceutics 14:12, pages 2757.
Crossref
Elisa M.T. Melloni, Beatrice Bravi, Sara Poletti, Sara Dallaspezia, Barbara Barbini, Raffaella Zanardi & Francesco Benedetti. (2022) Antidepressant chronotherapeutics normalizes prefrontal 1H-MRS glutamate in bipolar depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 119, pages 110606.
Crossref
Yajie Jiang, Manshu Zou, Tingting Ren & Yuhong Wang. (2022) Are mGluR2/3 Inhibitors Potential Compounds for Novel Antidepressants?. Cellular and Molecular Neurobiology.
Crossref
Joao E. Rodrigues, Ana Martinho, Vítor Santos, Catia Santa, Nuno Madeira, Maria J. Martins, Carlos N. Pato, Antonio Macedo & Bruno Manadas. (2022) Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Bipolar Disorder. International Journal of Molecular Sciences 23:10, pages 5460.
Crossref
Jérémy Sitbon, Dennis Nestvogel, Caroline Kappeler, Aude Nicolas, Stephanie Maciuba, Annabelle Henrion, Réjane Troudet, Elisa Courtois, Gaël Grannec, Violaine Latapie, Caroline Barau, Philippe Le Corvoisier, Nicolas Pietrancosta, Chantal Henry, Marion Leboyer, Bruno Etain, Marika Nosten-Bertrand, Thomas F. J. Martin, JeongSeop Rhee & Stéphane Jamain. (2022) CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress. Molecular Psychiatry 27:2, pages 1145-1157.
Crossref
Min Chen, Hongjun Tian, Guoyong Huang, Tao Fang, Xiaodong Lin, Jianmin Shan, Ziyao Cai, Gaungdong Chen, Suling Chen, Ce Chen, Jing Ping, Langlang Cheng, Chunmian Chen, Jingjing Zhu, Feifei Zhao, Deguo Jiang, Chuanxin Liu, Guangchuan Huang, Chongguang Lin & Chuanjun Zhuo. (2021) Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study. Translational Psychiatry 11:1.
Crossref
Zorana Kurbalija Novičić, Robert Bodén, Ksenija Kozarski, Mihailo Jelić, Vladimir M. Jovanović & Janet L. Cunningham. (2020) Lithium influences whole‐organism metabolic rate in Drosophila subobscura . Journal of Neuroscience Research 99:1, pages 407-418.
Crossref
Shinsuke Hidese, Kotaro Hattori, Daimei Sasayama, Takuya Tsumagari, Tomoko Miyakawa, Ryo Matsumura, Yuuki Yokota, Ikki Ishida, Junko Matsuo, Sumiko Yoshida, Miho Ota & Hiroshi Kunugi. (2020) Cerebrospinal fluid neuroplasticity-associated protein levels in patients with psychiatric disorders: a multiplex immunoassay study. Translational Psychiatry 10:1.
Crossref
Gabriel R. Fries, Consuelo Walss-Bass, Moises E. Bauer & Antonio L. Teixeira. (2019) Revisiting inflammation in bipolar disorder. Pharmacology Biochemistry and Behavior 177, pages 12-19.
Crossref
Nirit Z. Kara, Shlomit Flaisher-Grinberg, Grant W. Anderson, Galila Agam & Haim Einat. (2018) Mood-stabilizing effects of rapamycin and its analog temsirolimus: relevance to autophagy. Behavioural Pharmacology 29:4, pages 379-384.
Crossref
Rodrigo Machado-Vieira. (2018) Lithium, Stress, and Resilience in Bipolar Disorder: Deciphering this key homeostatic synaptic plasticity regulator. Journal of Affective Disorders 233, pages 92-99.
Crossref
Nathalia Zak, Torgeir Moberget, Erlend Bøen, Birgitte Boye, Trine R. Waage, Espen Dietrichs, Nina Harkestad, Ulrik F. Malt, Lars T. Westlye, Ole A. Andreassen, Stein Andersson & Torbjørn Elvsåshagen. (2018) Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals. Translational Psychiatry 8:1.
Crossref
Agata Szulc, Magdalena Wiedlocha, Napoleon Waszkiewicz, Beata Galińska-Skok, Piotr Marcinowicz, Jacek Gierus & Anna Mosiolek. (2018) Proton magnetic resonance spectroscopy changes after lithium treatment. Systematic review. Psychiatry Research: Neuroimaging 273, pages 1-8.
Crossref
Jean-Pol Lanquart, Pasquale Nardone, Philippe Hubain, Gwénolé Loas & Paul Linkowski. (2018) The dichotomy between low frequency and delta waves in human sleep: A reappraisal. Journal of Neuroscience Methods 293, pages 234-246.
Crossref
Vivian Kafantaris, Linda Spritzer, Vishal Doshi, Ema Saito & Philip R Szeszko. (2017) Changes in white matter microstructure predict lithium response in adolescents with bipolar disorder. Bipolar Disorders 19:7, pages 587-594.
Crossref
Sarah Delcourte, Erika Abrial, Adeline Etiévant, Renaud Rovera, Jørn Arnt, Michael Didriksen & Nasser Haddjeri. (2017) Asenapine modulates mood-related behaviors and 5-HT 1A/7 receptors-mediated neurotransmission . CNS Neuroscience & Therapeutics 23:6, pages 518-525.
Crossref
Rodrigo Machado-Vieira, Ioline D. Henter & Carlos A. Zarate Jr.. (2017) New targets for rapid antidepressant action. Progress in Neurobiology 152, pages 21-37.
Crossref
M G Soeiro-de-Souza, B Lafer, R A Moreno, F G Nery, T Chile, K Chaim, C da Costa Leite, R Machado-Vieira, M C G Otaduy & H Vallada. (2017) The CACNA1C risk allele rs1006737 is associated with age-related prefrontal cortical thinning in bipolar I disorder. Translational Psychiatry 7:4, pages e1086-e1086.
Crossref
Rodrigo Machado-Vieira, Marcus V. Zanetti, Maria C. Otaduy, Rafael T. De Sousa, Marcio G. Soeiro-de-Souza, Alana C. Costa, Andre F. Carvalho, Claudia C. Leite, Geraldo F. Busatto, Carlos A. Zarate & Wagner F. Gattaz. (2017) Increased Brain Lactate During Depressive Episodes and Reversal Effects by Lithium Monotherapy in Drug-Naive Bipolar Disorder. Journal of Clinical Psychopharmacology 37:1, pages 40-45.
Crossref
S. Poletti, V. Aggio, T.A. Hoogenboezem, O. Ambrée, H. de Wit, A.J.M. Wijkhuijs, C. Locatelli, C. Colombo, V. Arolt, H.A. Drexhage & F. Benedetti. (2016) Brain-Derived Neurotrophic Factor (Bdnf) and Gray Matter Volume in Bipolar Disorder. European Psychiatry 40, pages 33-37.
Crossref
R. Machado-Vieira, I. Henter, C.A. ZarateJr.Jr. & H.K. Manji. 2017. Reference Module in Neuroscience and Biobehavioral Psychology. Reference Module in Neuroscience and Biobehavioral Psychology.
Breno Satler Diniz, Chien-Wei Lin, Etienne Sibille, George Tseng, Francis Lotrich, Howard J. Aizenstein, Charles F. Reynolds & Meryl A. Butters. (2016) Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven approach to understanding LLD pathophysiology. Journal of Psychiatric Research 82, pages 1-7.
Crossref
Chen Zhang, Zhiguo Wu, Wu Hong, Daihui Peng & Yiru Fang. (2016) Evaluating the association between the SHANK3 gene and bipolar disorder. Psychiatry Research 244, pages 284-288.
Crossref
Luca Muzio, Valentina Brambilla, Lorenza Calcaterra, Patrizia D’Adamo, Gianvito Martino & Francesco Benedetti. (2016) Increased neuroplasticity and hippocampal microglia activation in a mice model of rapid antidepressant treatment. Behavioural Brain Research 311, pages 392-402.
Crossref
Rugül Köse Çinar, Mehmet Bülent Sönmez & Yasemin Görgülü. (2016) Peripheral blood mRNA expressions of stress biomarkers in manic episode and subsequent remission. Psychoneuroendocrinology 70, pages 10-16.
Crossref
K. Sue O'Shea & Melvin G. McInnis. (2016) Neurodevelopmental origins of bipolar disorder: iPSC models. Molecular and Cellular Neuroscience 73, pages 63-83.
Crossref
R.W. Logan & C.A. McClung. (2016) Animal models of bipolar mania: The past, present and future. Neuroscience 321, pages 163-188.
Crossref
R. Machado-Vieira, M. C. Otaduy, M. V. Zanetti, R. T. De Sousa, V. V. Dias, C. C. Leite, O. V. Forlenza, G. F. Busatto, J. C. Soares & W. F. Gattaz. (2016) A Selective Association between Central and Peripheral Lithium Levels in Remitters in Bipolar Depression: A 3T- 7 Li Magnetic Resonance Spectroscopy Study . Acta Psychiatrica Scandinavica 133:3, pages 214-220.
Crossref
N Sousa. (2016) The dynamics of the stress neuromatrix. Molecular Psychiatry 21:3, pages 302-312.
Crossref
Rodrigo Machado-Vieira, Wagner F. Gattaz, Marcus V. Zanetti, Rafael T. De Sousa, Andre F. Carvalho, Marcio G. Soeiro-de-Souza, Claudia C. Leite & Maria C. Otaduy. (2015) A Longitudinal (6-week) 3T 1H-MRS Study on the Effects of Lithium Treatment on Anterior Cingulate Cortex Metabolites in Bipolar Depression. European Neuropsychopharmacology 25:12, pages 2311-2317.
Crossref
Cheng-Ta Li, Pei-Chi Tu, Jen-Chuen Hsieh, Hsin-Chen Lee, Ya-Mei Bai, Chia-Fen Tsai, Shyh-Jen Wang, Ju-Wei Hsu, Kai-Lin Huang, Chen-Jee Hong & Tung-Ping Su. (2015) Functional dysconnection in the prefrontal-amygdala circuitry in unaffected siblings of patients with bipolar I disorder. Bipolar Disorders 17:6, pages 626-635.
Crossref
Rafael T. de Sousa, Emilio L. Streck, Orestes V. Forlenza, Andre R. Brunoni, Marcus V. Zanetti, Gabriela K. Ferreira, Breno S. Diniz, Luis V. Portela, André F. Carvalho, Carlos A. ZarateJr.Jr., Wagner F. Gattaz & Rodrigo Machado-Vieira. (2015) Regulation of leukocyte tricarboxylic acid cycle in drug-naïve Bipolar Disorder. Neuroscience Letters 605, pages 65-68.
Crossref
Biju Viswanath, Sam P. Jose, Alessio Squassina, Jagadisha Thirthalli, Meera Purushottam, Odity Mukherjee, Vladimir Vladimirov, George P. Patrinos, Maria Del Zompo & Sanjeev Jain. (2015) Cellular models to study bipolar disorder: A systematic review. Journal of Affective Disorders 184, pages 36-50.
Crossref
C Nasca, B Bigio, D Zelli, F Nicoletti & B S McEwen. (2014) Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility. Molecular Psychiatry 20:6, pages 755-763.
Crossref
Marcus V. Zanetti, Maria C. Otaduy, Rafael T. de Sousa, Wagner F. Gattaz, Geraldo F. Busatto, Claudia C. Leite & Rodrigo Machado-Vieira. (2015) Bimodal Effect of Lithium Plasma Levels on Hippocampal Glutamate Concentrations in Bipolar II Depression: A Pilot Study. International Journal of Neuropsychopharmacology 18:6.
Crossref
Rodrigo Machado-Vieira, Marcus V. Zanetti, Antonio L. Teixeira, Miyuki Uno, Leandro L. Valiengo, Marcio G. Soeiro-de-Souza, Sueli M. Oba-Shinjo, Rafael T. de Sousa, Carlos. A. ZarateJr.Jr., Wagner F. Gattaz & Suely K.N. Marie. (2015) Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder. European Neuropsychopharmacology 25:4, pages 468-473.
Crossref
Rafael T. de Sousa, Marcus V. Zanetti, Leda L. Talib, Mauricio H. Serpa, Tiffany M. Chaim, Andre F. Carvalho, Andre R. Brunoni, Geraldo F. Busatto, Wagner F. Gattaz & Rodrigo Machado-Vieira. (2015) Lithium increases platelet serine-9 phosphorylated GSK-3β levels in drug-free bipolar disorder during depressive episodes. Journal of Psychiatric Research 62, pages 78-83.
Crossref
Gregor Hasler & Andreas Wolf. (2015) Toward stratified treatments for bipolar disorders. European Neuropsychopharmacology 25:3, pages 283-294.
Crossref
Erika Abrial, Alexandre Bétourné, Adeline Etiévant, Guillaume Lucas, Hélène Scarna, Laura Lambás-Señas & Nasser Haddjeri. (2015) Protein Kinase C Inhibition Rescues Manic-Like Behaviors and Hippocampal Cell Proliferation Deficits in the Sleep Deprivation Model of Mania. International Journal of Neuropsychopharmacology 18:2.
Crossref
Annie J. Xu, Mark J. Niciu, Nancy B. Lundin, David A. Luckenbaugh, Dawn F. Ionescu, Erica M. Richards, Jennifer L. Vande Voort, Elizabeth D. Ballard, Nancy E. Brutsche, Rodrigo Machado-Vieira & Carlos A. Zarate. (2015) Lithium and Valproate Levels Do Not Correlate with Ketamine’s Antidepressant Efficacy in Treatment-Resistant Bipolar Depression. Neural Plasticity 2015, pages 1-7.
Crossref
Rodrigo Machado-Vieira, Benicio N. Frey, Ana C. Andreazza & João Quevedo. (2015) Translational Research in Bipolar Disorders. Neural Plasticity 2015, pages 1-3.
Crossref
Rafael T. de Sousa, Emilio L. Streck, Marcus V. Zanetti, Gabriela K. Ferreira, Breno S. Diniz, Andre R. Brunoni, Geraldo F. Busatto, Wagner F. Gattaz & Rodrigo Machado-Vieira. (2014) Lithium increases leukocyte mitochondrial complex I activity in bipolar disorder during depressive episodes. Psychopharmacology 232:1, pages 245-250.
Crossref
Antonio L. Teixeira, Rafael T. de Souza, Marcus V. Zanetti, Andre R. Brunoni, Geraldo F. Busatto, Carlos A. ZarateJr.Jr., Wagner F. Gattaz & Rodrigo Machado-Vieira. (2015) Increased plasma levels of soluble TNF receptors 1 and 2 in bipolar depression and impact of lithium treatment. Human Psychopharmacology: Clinical and Experimental 30:1, pages 52-56.
Crossref
Adam J. Walker, Yesul Kim, J. Blair Price, Rajas P. Kale, Jane A. McGillivray, Michael Berk & Susannah J. Tye. (2014) Stress, Inflammation, and Cellular Vulnerability during Early Stages of Affective Disorders: Biomarker Strategies and Opportunities for Prevention and Intervention. Frontiers in Psychiatry 5.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.