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Research Article

Maternal inhalation of surface-coated nanosized titanium dioxide (UV-Titan) in C57BL/6 mice: effects in prenatally exposed offspring on hepatic DNA damage and gene expression

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Pages 85-96 | Received 06 Jul 2011, Accepted 28 Sep 2011, Published online: 28 Nov 2011

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Jeremy K. Larson, Michael J. CarvanIIIIII & Reinhold J. Hutz. (2014) Engineered Nanomaterials: An Emerging Class of Novel Endocrine Disruptors1. Biology of Reproduction 91:1.
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Yang Li, Yi Zhang & Bing Yan. (2014) Nanotoxicity Overview: Nano-Threat to Susceptible Populations. International Journal of Molecular Sciences 15:3, pages 3671-3697.
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Crossref
Hongbo Shi, Ruth Magaye, Vincent Castranova & Jinshun Zhao. (2013) Titanium dioxide nanoparticles: a review of current toxicological data. Particle and Fibre Toxicology 10:1.
Crossref
P. Jackson, L. M. Pedersen, Z. O. Kyjovska, N. R. Jacobsen, A. T. Saber, K. S. Hougaard, U. Vogel & H. Wallin. (2013) Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay. Mutagenesis 28:6, pages 699-707.
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Crossref
Jianling Sun, Qiu Zhang, Zhiping Wang & Bing Yan. (2013) Effects of Nanotoxicity on Female Reproductivity and Fetal Development in Animal Models. International Journal of Molecular Sciences 14:5, pages 9319-9337.
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Xiaoyang Zhao, Yuguan Ze, Guodong Gao, Xuezi Sang, Bing Li, Suxin Gui, Lei Sheng, Qingqing Sun, Jie Cheng, Zhe Cheng, Renping Hu, Ling Wang & Fashui Hong. (2013) Nanosized TiO2-Induced Reproductive System Dysfunction and Its Mechanism in Female Mice. PLoS ONE 8:4, pages e59378.
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