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Nanotoxicology Volume 9, 2015 - Issue 2
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Original Article

Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay

Bianca M. RotoliUnit of General Pathology and
,
Rita GattiUnit of Anatomy and Histology, Department of Biomedical, Biotechnological and Translational Sciences (SBiBiT), University of Parma, Parma, Italy,
,
Dania MoviaCentre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin, Ireland,
,
Massimiliano G. BianchiUnit of Occupational Medicine, Department of Clinical and Experimental Medicine, Parma, Italy,
,
Luisana Di CristoUnit of Occupational Medicine, Department of Clinical and Experimental Medicine, Parma, Italy,
,
Ivana FenoglioDepartment of Chemistry, Interdepartmental Center for Nanostructured Interfaces and Surfaces (NIS), and “G. Scansetti” Interdepartmental Center for Studies on Asbestos and other Toxic Particulates, University of Torino, Torino, Italy,
,
Fabio SonvicoGraduate School of Health – Pharmacy, University of Technology Sydney, Sydney, Australia, and
,
Enrico BergamaschiUnit of Occupational Medicine, Department of Clinical and Experimental Medicine, Parma, Italy, Correspondence[email protected]
,
Adriele Prina-MelloCentre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, Dublin, Ireland, ;School of Medicine, Trinity College Dublin, Dublin, IrelandCorrespondence[email protected]
&
Ovidio BussolatiUnit of General Pathology and
show all
Pages 230-241 | Received 29 Oct 2013, Accepted 22 Apr 2014, Published online: 29 May 2014

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Massimiliano G. Bianchi, Luisa Campagnolo, Manfredi Allegri, Simona Ortelli, Magda Blosi, Martina Chiu, Giuseppe Taurino, Valentina Lacconi, Antonio Pietroiusti, Anna L. Costa, Craig A. Poland, Daniel Baird, Rodger Duffin, Ovidio Bussolati & Enrico Bergamaschi. (2020) Length-dependent toxicity of TiO2 nanofibers: mitigation via shortening. Nanotoxicology 14:4, pages 433-452.
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Gabriela Garrastazu Pereira, Amanda Jane Lawson, Francesca Buttini & Fabio Sonvico. (2016) Loco-regional administration of nanomedicines for the treatment of lung cancer. Drug Delivery 23:8, pages 2881-2896.
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K. Kyriakidou, D. Brasinika, A.F.A. Trompeta, E. Bergamaschi, I.K. Karoussis & C.A. Charitidis. (2020) In vitro cytotoxicity assessment of pristine and carboxyl-functionalized MWCNTs. Food and Chemical Toxicology 141, pages 111374.
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Wen‐Song Xi, Huan Tang, Yuan‐Yuan Liu, Chun‐Yuan Liu, Yanfeng Gao, Aoneng Cao, Yuanfang Liu, Zhang Chen & Haifang Wang. (2019) Cytotoxicity of vanadium oxide nanoparticles and titanium dioxide‐coated vanadium oxide nanoparticles to human lung cells. Journal of Applied Toxicology 40:5, pages 567-577.
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L. Di Cristo, B. Grimaldi, T. Catelani, E. Vázquez, P.P. Pompa & S. Sabella. (2020) Repeated exposure to aerosolized graphene oxide mediates autophagy inhibition and inflammation in a three-dimensional human airway model. Materials Today Bio 6, pages 100050.
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Massimiliano G. Bianchi, Martina Chiu, Giuseppe Taurino, Furio Brighenti, Daniele Del Rio, Pedro Mena & Ovidio Bussolati. (2019) Catechin and Procyanidin B2 Modulate the Expression of Tight Junction Proteins but Do Not Protect from Inflammation-Induced Changes in Permeability in Human Intestinal Cell Monolayers. Nutrients 11:10, pages 2271.
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Di Cristo, Bianchi, Chiu, Taurino, Donato, Garzaro, Bussolati & Bergamaschi. (2019) Comparative in Vitro Cytotoxicity of Realistic Doses of Benchmark Multi-Walled Carbon Nanotubes towards Macrophages and Airway Epithelial Cells. Nanomaterials 9:7, pages 982.
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Mohamed H. Lahiani, Sangeeta Khare, Carl E. Cerniglia, Ramiz Boy, Ilia N. Ivanov & Mariya Khodakovskaya. (2019) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition. Nanoscale 11:8, pages 3639-3655.
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Massimiliano G. Bianchi, Ovidio Bussolati, Martina Chiu, Giuseppe Taurino & Enrico Bergamaschi. 2019. Exposure to Engineered Nanomaterials in the Environment. Exposure to Engineered Nanomaterials in the Environment 263 287 .
Hong Wang, Nianhui Zhai, Ying Chen, Chongyang Fu & Kehe Huang. (2018) OTA induces intestinal epithelial barrier dysfunction and tight junction disruption in IPEC-J2 cells through ROS/Ca2+-mediated MLCK activation. Environmental Pollution 242, pages 106-112.
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Luisana Di Cristo, Sarah Mc Carthy, Keith Paton, Dania Movia & Adriele Prina-Mello. (2018) Interplay between oxidative stress and endoplasmic reticulum stress mediated- autophagy in unfunctionalised few-layer graphene-exposed macrophages. 2D Materials 5:4, pages 045033.
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Luisana Di Cristo, Ciaran Maguire, Karen Mc Quillan, Mattia Aleardi, Yuri Volkov, Dania Movia & Adriele Prina-Mello. (2018) Towards the Identification of an In Vitro Tool for Assessing the Biological Behavior of Aerosol Supplied Nanomaterials. International Journal of Environmental Research and Public Health 15:4, pages 563.
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Dania Movia, Luisana Di Cristo, Roaa Alnemari, Joseph E. McCarthy, Hanane Moustaoui, Marc Lamy de la Chapelle, Jolanda Spadavecchia, Yuri Volkov & Adriele Prina-Mello. (2017) The curious case of how mimicking physiological complexity in in vitro models of the human respiratory system influences the inflammatory responses. A preliminary study focused on gold nanoparticles. Journal of Interdisciplinary Nanomedicine 2:2, pages 110-130.
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Enrico Bergamaschi, Irina Guseva Canu, Adriele Prina-Mello & Andrea Magrini. 2017. Adverse Effects of Engineered Nanomaterials. Adverse Effects of Engineered Nanomaterials 125 158 .
Henriqueta Louro, Mariana Pinhão, Joana Santos, Ana Tavares, Nádia Vital & Maria João Silva. (2016) Evaluation of the cytotoxic and genotoxic effects of benchmark multi-walled carbon nanotubes in relation to their physicochemical properties. Toxicology Letters 262, pages 123-134.
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Patinya Sukwong, Koravit Somkid, Supunsa Kongseng, Dakrong Pissuwan & Krongtong Yoovathaworn. (2016) Respiratory tract toxicity of titanium dioxide nanoparticles and multi‐walled carbon nanotubes on mice after intranasal exposure. Micro & Nano Letters 11:4, pages 183-187.
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Leslie C. ThompsonNathan A. HollandRyan J. Snyder, Bin LuoDaniel P. BecakJillian T. OdomBenjamin S. Harrison, Jared M. BrownKymberly M. GowdyChristopher J. Wingard. (2016) Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling. American Journal of Physiology-Lung Cellular and Molecular Physiology 310:2, pages L142-L154.
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Manfredi Allegri, Dimitrios K. Perivoliotis, Massimiliano G. Bianchi, Martina Chiu, Alessandra Pagliaro, Malamatenia A. Koklioti, Aikaterini-Flora A. Trompeta, Enrico Bergamaschi, Ovidio Bussolati & Constantinos A. Charitidis. (2016) Toxicity determinants of multi-walled carbon nanotubes: The relationship between functionalization and agglomeration. Toxicology Reports 3, pages 230-243.
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Antonio Pietroiusti, Lang Tran & Luisa Campagnolo. (2015) Nanosafety forum for young scientists: a meeting report. European Journal of Nanomedicine 7:3.
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