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Original Article

Osseointegrated Titanium Implants: Requirements for Ensuring a Long-Lasting, Direct Bone-to-Implant Anchorage in Man

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Pages 155-170 | Accepted 20 Jul 1980, Published online: 08 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Matthew D. Wadge, Jamie McGuire, Kathryn G. Thomas, Bryan W. Stuart, Reda M. Felfel, Ifty Ahmed & David M. Grant. (2023) Developing alkaline titanate surfaces for medical applications. International Materials Reviews 68:6, pages 677-724.
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Michael Levin, Robert C Spiro, Himanshu Jain & Matthias M Falk. (2022) Effects of Titanium Implant Surface Topology on Bone Cell Attachment and Proliferation in vitro. Medical Devices: Evidence and Research 15, pages 103-119.
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Carl-Johan Ivanoff, Jonas Lindhe, Stefan Ellner, Karl Johan Johansson & Peter Abrahamsson. (2021) An open, randomised, multi-centre study, comparing straight and tapered apex implants design, in partially and totally edentulous maxillae. Acta Odontologica Scandinavica 79:7, pages 492-498.
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Subhasmita Swain, R. D. K. Misra, C. K. You & Tapash R. Rautray. (2021) TiO2 nanotubes synthesised on Ti-6Al-4V ELI exhibits enhanced osteogenic activity: A potential next-generation material to be used as medical implants. Materials Technology 36:7, pages 393-399.
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Muhammad Akram, Nasima Arshad & Annabel Braem. (2021) Fabrication of corrosion-resistant chitosan–gelatin–bioactive glass-ZnO/CeO2 hybrid coating on magnesium ZK60 alloy by AC-EPD. Journal of Taibah University for Science 15:1, pages 312-320.
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Md Al-Amin, Ahmad Majdi Abdul Rani, Abdul Azeez Abdu Aliyu, Muhammad Al’Hapis Abdul Razak, Sri Hastuty & Michael G Bryant. (2020) Powder mixed-EDM for potential biomedical applications: A critical review. Materials and Manufacturing Processes 35:16, pages 1789-1811.
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Vahidreza Jafari Harandi, David Charles Ackland, Raneem Haddara, L. Eduardo Cofré Lizama, Mark Graf, Mary Pauline Galea & Peter Vee Sin Lee. (2020) Individual muscle contributions to hip joint-contact forces during walking in unilateral transfemoral amputees with osseointegrated prostheses. Computer Methods in Biomechanics and Biomedical Engineering 23:14, pages 1071-1081.
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Yun He, Istabrak Hasan, Ludger Keilig, Dominik Fischer, Luisa Ziegler, Marcus Abboud, Gerhard Wahl & Christoph Bourauel. (2018) Numerical investigation of bone remodelling around immediately loaded dental implants using sika deer (Cervus nippon) antlers as implant bed. Computer Methods in Biomechanics and Biomedical Engineering 21:4, pages 359-369.
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Rafał Pokrowiecki, Agnieszka Mielczarek, Tomasz Zaręba & Stefan Tyski. (2017) Oral microbiome and peri-implant diseases: where are we now?. Therapeutics and Clinical Risk Management 13, pages 1529-1542.
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Naiwen Tan, Xiangwei Liu, Yanhui Cai, Sijia Zhang, Bo Jian, Yuchao Zhou, Xiaoru Xu, Shuai Ren, Hongbo Wei & Yingliang Song. (2017) The influence of direct laser metal sintering implants on the early stages of osseointegration in diabetic mini-pigs. International Journal of Nanomedicine 12, pages 5433-5442.
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Xiaochen Zhang, Zhiyuan Zhang, Gang Shen & Jun Zhao. (2016) Enhanced osteogenic activity and anti-inflammatory properties of Lenti-BMP-2-loaded TiO2 nanotube layers fabricated by lyophilization following trehalose addition. International Journal of Nanomedicine 11, pages 429-439.
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María Prados-Privado, Juan Carlos Prados-Frutos, José Luis Calvo-Guirado & José Antonio Bea. (2016) A random fatigue of mechanize titanium abutment studied with Markoff chain and stochastic finite element formulation. Computer Methods in Biomechanics and Biomedical Engineering 19:15, pages 1583-1591.
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Xinjie Cai, Jing Cai, Kena Ma, Pin Huang, Lingling Gong, Dan Huang, Tao Jiang & Yining Wang. (2016) Fabrication and characterization of Mg-doped chitosan–gelatin nanocompound coatings for titanium surface functionalization. Journal of Biomaterials Science, Polymer Edition 27:10, pages 954-971.
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Serkan Dundar, Tolga Topkaya, Murat Yavuz Solmaz, Ferhan Yaman, Yusuf Atalay, Arif Saybak, Fatih Asutay & Omer Cakmak. (2016) Finite element analysis of the stress distributions in peri-implant bone in modified and standard-threaded dental implants. Biotechnology & Biotechnological Equipment 30:1, pages 127-133.
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Jae-Kwan Lee, Dong-Soon Choi, Insan Jang & Won-Youl Choi. (2015) Improved osseointegration of dental titanium implants by TiO2 nanotube arrays with recombinant human bone morphogenetic protein-2: a pilot in vivo study. International Journal of Nanomedicine 10, pages 1145-1154.
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Jonas Anderud, Peter Abrahamsson, Ryo Jimbo, Sten Isaksson, Erik Adolfsson, Johan Malmström, Yoshihito Naito & Ann Wennerberg. (2015) Guided bone augmentation using ceramic space-maintaining devices: the impact of chemistry. Clinical, Cosmetic and Investigational Dentistry 7, pages 45-53.
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M S Uddin, Colin Hall & Peter Murphy. (2015) Surface treatments for controlling corrosion rate of biodegradable Mg and Mg-based alloy implants. Science and Technology of Advanced Materials 16:5.
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Simonetta Monini, Isotta Musy, Chiara Filippi, Francesca Atturo & Maurizio Barbara. (2015) Bone conductive implants in single-sided deafness. Acta Oto-Laryngologica 135:4, pages 381-388.
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Brad M Isaacson & Sujee Jeyapalina. (2014) Osseointegration: a review of the fundamentals for assuring cementless skeletal fixation. Orthopedic Research and Reviews 6, pages 55-65.
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Alon Frydman & Krikor Simonian. (2014) Review of Models for Titanium as a Foreign Body. Journal of the California Dental Association 42:12, pages 829-833.
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. (2014) Teeth in the Era of Implant Dentistry. Journal of the California Dental Association 42:12, pages 821-827.
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K. M. Lee, B. K. Jung, Y. G. Ko & D. H. Shin. (2014) Electrochemical response of ZrO2 incorporated titanium oxide film. Materials Research Innovations 18:sup2, pages S2-407-S2-410.
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Joon-Seok Lee & Young-Jun Lim. (2013) Three-dimensional numerical simulation of stress induced by different lengths of osseointegrated implants in the anterior maxilla. Computer Methods in Biomechanics and Biomedical Engineering 16:11, pages 1143-1149.
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Jee Ha, Stanley J. Osher & Ichiro Nishimura. (2013) Mathematical Filtering Minimizes Metallic Halation of Titanium Implants in Micro CT Images. Journal of the California Dental Association 41:1, pages 41-45.
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Gökçe Meriç, Erkan Erkmen, Ahmet Kurt, Atilim Eser & Ahmet Utku özden. (2012) Biomechanical comparison of two different collar structured implants supporting 3-unit fixed partial denture: A 3-D FEM study. Acta Odontologica Scandinavica 70:1, pages 61-71.
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Umer Daood, Ninette Bandey, Saad Bin Qasim, Hanan Omar & Saad A. Khan. (2011) Surface characterization analysis of failed dental implants using scanning electron microscopy. Acta Odontologica Scandinavica 69:6, pages 367-373.
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A John Timperley, Iulian Nusem, Kathy Wilson, Sarah L Whitehouse, Pieter Buma & Ross W Crawford. (2010) A modified cementing technique using BoneSource to augment fixation of the acetabulum in a sheep model. Acta Orthopaedica 81:4, pages 503-507.
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Carlos Nelson Elias & Luiz Meirelles. (2010) Improving osseointegration of dental implants. Expert Review of Medical Devices 7:2, pages 241-256.
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Maiken Stilling. (2009) Polyethylene wear analysis. Acta Orthopaedica 80:sup337, pages 1-74.
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Ann Wennerberg & Tomas Albrektsson. (2009) Structural influence from calcium phosphate coatings and its possible effect on enhanced bone integration. Acta Odontologica Scandinavica 67:6, pages 333-340.
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M. E. Khosroshahi, M. Mahmoodi, H. Saeedinasab & M. Tahriri. (2008) Evaluation of mechanical and electrochemical properties of laser surface modified Ti–6Al–4V for biomedical applications: in vitro study. Surface Engineering 24:3, pages 209-218.
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Göran Lundborg, Jack Besjakov & Per-Ingvar Brånemark. (2007) Osseointegrated wrist-joint prostheses: A 15-year follow-up with focus on bony fixation. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery 41:3, pages 130-137.
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Lars V Carlsson, Tomas Albrektsson, Björn E J Albrektsson, C Magnus Jacobsson, Warren Macdonald, Lars Regnér & Lars R Weidenhielm. (2006) Stepwise introduction of a bone-conserving osseointegrated hip arthroplasty using RSA and a randomized study: II. Clinical proof of concept—40 patients followed for 2 years. Acta Orthopaedica 77:4, pages 559-566.
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Lars V Carlsson, Björn E J Albrektsson, Björn G Albrektsson, Tomas O Albrektsson, C Magnus Jacobsson, Warren Macdonald, Lars Regnér, Tord Röstlund & Lars R Weidenhielm. (2006) Stepwise introduction of a bone-conserving osseointegrated hip arthroplasty using RSA and a randomized study: I. Preliminary investigations—52 patients followed for 3 years. Acta Orthopaedica 77:4, pages 549-558.
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Krikor Derbabian & Krikor Simonian. (2005) Immediate Loading of Dental Implants: Overview and Rationale. Journal of the California Dental Association 33:4, pages 337-341.
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S. F. H. Ismail & A. S. Johal. (2002) The role of implants in orthodontics. Journal of Orthodontics 29:3, pages 239-245.
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Rómulo Luis Cabrini, Daniel Olmedo, Victor Hugo Tomasi & María Beatriz Guglielmotti. (2002) Microincineration for the Detection of Titanium in Tissue Sections. Journal of Histotechnology 25:2, pages 75-78.
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Marc N Thomsen, Steffen J Breusch, Peter R Aldinger, Wolfgang Görtz, Andreas Lahmer, Mathias Honl, Andreas Birke & Hans Nägerl. (2002) Robotically-milled bone cavities. Acta Orthopaedica Scandinavica 73:4, pages 379-385.
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Hala Zreiqat, Clive McFarland & Cameron R. Howlett. (1999) The effect of polymeric chemistry on the expression of bone-related mRNAs and proteins by human bone-derived cells in vitro. Journal of Biomaterials Science, Polymer Edition 10:2, pages 199-216.
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Christian P Delaunay & Adalbert I Kapandji. (1998) Survivorship of rough-surfaced threaded acetabular cups 382: Consecutive primary Zweymiiller cups followed for 0.2–12 years. Acta Orthopaedica Scandinavica 69:4, pages 379-383.
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M. Fadda, M. Marcacci, S. Toksvig-larsen, T. Wang And & R. Meneghello. (1998) Improving accuracy of bone resections using robotics tool holder and a high speed milling cutting tool. Journal of Medical Engineering & Technology 22:6, pages 280-284.
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Å. Leonhardt, J. Olsson & G. Dahlén. (1995) In vitro Adhesion and Ribotypes Among Oral Bacteria Isolated From Plaque on Titanium, Hydroxyapatite and Amalgam Surfaces. Microbial Ecology in Health and Disease 8:6, pages 293-301.
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M. E. Krizan, R. L. Schneider, R. L. Ettinger, M. J. Buckley, W. E. Lavelle & J. C. Keller. (1994) Preparation and Methods for Sequential Evaluation of Titanium Implant Interfaces in Plastic Embedded Calcified Bone. Journal of Histotechnology 17:4, pages 333-341.
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Kjeld Søballe. (1993) Hydroxyapatite ceramic coating for bone implant fixation. Acta Orthopaedica Scandinavica 64:sup255, pages 1-58.
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Lars Nimb Jensen, Bjarne Lund & Klaus Gotfredsen. (1990) Bone growth into a revised porous-coated patellar implant. Acta Orthopaedica Scandinavica 61:3, pages 213-216.
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Søren Toksvig Larsen & Leif Ryd. (1989) Temperature elevation during knee arthroplasty. Acta Orthopaedica Scandinavica 60:4, pages 439-442.
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Bryan E. Pfingst, Josef M. Miller, Anders Tjellström, Tomas Albrektsson & Lynn Carlisle. (1989) Development of Cochlear-wall Implants for Electrical Stimulation of the Auditory Nerve. Acta Oto-Laryngologica 107:3-4, pages 210-218.
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Lars Carlsson, Tord Röstlund, Björn Albrektsson & Tomas Albrektsson. (1988) Implant fixation improved by close fit Cylindrical implant – bone interface studied in rabbits. Acta Orthopaedica Scandinavica 59:3, pages 272-275.
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Krister Djerf & Jan Gillquist. (1987) Calcar unloading after hip replacement: A cadaver study of femoral stem designs. Acta Orthopaedica Scandinavica 58:2, pages 97-103.
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R.E. Baier. (1986) Modification of Surfaces to Meet Bioadhesive Design Goals: A Review. The Journal of Adhesion 20:3, pages 171-186.
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Bengt Mjoberg. (1986) Loosening of the cemented hip prosthesis. Acta Orthopaedica Scandinavica 57:sup221, pages 3-40.
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Leif Ryd. (1986) Micromotion in knee arthroplasty. Acta Orthopaedica Scandinavica 57:sup220, pages 3-80.
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Bo Håkansson, Anders Tjellström, Ulf Rosenhall & Peder Carlsson. (1985) The Bone-Anchored Hearing Aid: Principal Design and a Psychoacoustical Evaluation. Acta Oto-Laryngologica 100:3-4, pages 229-239.
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R. N. Matthews, F. Fatah, D. M. Davies, J. Eyre, R. A. Hodge & G. P. Walsh-Waring. (1984) Experience with the Radial Forearm Flap in 14 Cases. Scandinavian Journal of Plastic and Reconstructive Surgery 18:3, pages 303-310.
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Lars Linder, Tomas Albrektsson, Per-Ingvar Branemark, Hans-Arne Hansson, Bengt Ivarsson, Ulf Jonsson & Ingemar Lundström. (1983) Electron Microscopic Analysis of the Bone-Titanium Interface. Acta Orthopaedica Scandinavica 54:1, pages 45-52.
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A. Tjellström, U. Rosenhall, J. Lindström, O. Hallén, T. Albrektsson & P. I. Brånemark. (1983) Five-Year Experience with Skin-Penetrating Bone-Anchored Implants in the Temporal Bone. Acta Oto-Laryngologica 95:5-6, pages 568-575.
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J. Wittbjer, B. Nosslin, B. Palmer & K.-G. Thorngren. (1982) Bone Formation of Transplanted Autologous Bone Matrix in Rabbit Evaluated by Technetium Radionuclide Bone Imaging. Scandinavian Journal of Plastic and Reconstructive Surgery 16:1, pages 23-28.
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P.-I. Brånemark & T. Albrektsson. (1982) Titanium Implants Permanently Penetrating Human Skin. Scandinavian Journal of Plastic and Reconstructive Surgery 16:1, pages 17-21.
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