Advanced search
Publication Cover
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 14, 2013 - Issue 5-6
Submit an article Journal homepage
1,322
Views
62
CrossRef citations to date
0
Altmetric
Clinical Trials

Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS

Ettore BeghiDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche ‘Mario Negri’, MilanoCorrespondence[email protected]
,
Elisabetta PupilloDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milano
,
Virginio BonitoU.O. Neurologia,Ospedali Riuniti di Bergamo
,
Paolo BuzziUnione Operative di Neurologia, A.O. Carlo Poma, Mantova
,
Claudia CaponnettoDipartimento di Neuroscienze, Oftalmologia e Genetica, IRCCS Azienda Ospedaliera Universitaria S. Martino − IST, Genova
,
Adriano ChiòDipartimento di Neuroscienze, Università di Torino
,
Massimo CorboNEuroMuscular Omnicentre (NEMO), Fondazione Serena Onlus, Ospedale Niguarda Ca’ Granda, Milano
,
Fabio GianniniDipartimento Scienze Neurologiche, Neurochirurgiche e del Comportamento – Università di Siena, Siena
,
Maurizio InghilleriDipartimento di Neurologia e Psichiatria, Università di Roma ‘Sapienza’, Roma
,
Vincenzo La BellaDipartimento di Biomedicina Sperimentale e di Neuroscienze Cliniche, Università di Palermo, Palermo
,
Giancarlo LogroscinoDipartimento di Neuroscienze e degli Organi di Senso, Università di Bari, Bari
,
Lorenzo LorussoU.O. di Neurologia, A.O. ‘Mellino Mellini’, Chiari, Brescia
,
Christian LunettaNEuroMuscular Omnicentre (NEMO), Fondazione Serena Onlus, Ospedale Niguarda Ca’ Granda, Milano
,
Letizia MazziniCentro SLA, A.O.U. Maggiore della Carità, Università di Novara, Novara
,
Paolo MessinaDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milano
,
Gabriele MoraIRCCS Fondazione Maugeri, Milano
,
Michele PeriniA.O. Ospedale San Antonio Abate, Gallarate, Varese
,
Maria Lidia QuadrelliDipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milano
,
Vincenzo SilaniDipartimento di Neurologia e Laboratorio di Neuroscienze, Centro ‘Dino Ferrari’, Università degli Studi di Milano − IRCCS Istituto Auxologico Italiano, Milano
,
Isabella L. SimoneDipartimento di Neuroscienze e degli Organi di Senso, Università di Bari, Bari
,
Lucio TremolizzoDipartimento di Neurologia, Ospedale San Gerardo, Monza Brianza, Italy
& The Italian ALS Study Group show all
Pages 397-405 | Received 06 Nov 2012, Accepted 03 Jan 2013, Published online: 19 Feb 2013

Citations (62)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (10)

Luca Diamanti, Elisa Bianchi, Klodjana Mucaj, Cristina Cereda, Silvio Garattini, Ettore Beghi & Elisabetta Pupillo. (2022) Drug treatments and interactions, disease progression and quality of life in ALS patients. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 23:5-6, pages 415-423.
Read now
. (2021) Theme 06 - TISSUE BIOMARKERS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 22:sup2, pages 104-120.
Read now
Helene Blasco, Debora Lanznaster, Charlotte Veyrat-Durebex, Rudolf Hergesheimer, Patrick Vourch, Francois Maillot, Christian R. Andres, Pierre-François Pradat & Phillipe Corcia. (2020) Understanding and managing metabolic dysfunction in Amyotrophic Lateral Sclerosis. Expert Review of Neurotherapeutics 20:9, pages 907-919.
Read now
. (2020) ALSUntangled 53: Carnitine supplements. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:5-6, pages 477-483.
Read now
Ruben PA van Eijk, Marinus JC Eijkemans, Dimitris Rizopoulos, Leonard H van den Berg & Stavros Nikolakopoulos. (2018) Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis. Clinical Epidemiology 10, pages 333-341.
Read now
Shyuan T Ngo, Jia D Mi, Robert D Henderson, Pamela A McCombe & Frederik J Steyn. (2017) Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions. Degenerative Neurological and Neuromuscular Disease 7, pages 95-108.
Read now
Koji Takei, Kikumi Tsuda, Fumihiro Takahashi, Manabu Hirai & Joseph Palumbo. (2017) An assessment of treatment guidelines, clinical practices, demographics, and progression of disease among patients with amyotrophic lateral sclerosis in Japan, the United States, and Europe. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18:sup1, pages 88-97.
Read now
H Blasco, F Patin, CR Andres, P Corcia & PH Gordon. (2016) Amyotrophic Lateral Sclerosis, 2016: existing therapies and the ongoing search for neuroprotection. Expert Opinion on Pharmacotherapy 17:12, pages 1669-1682.
Read now
Benoît Marin, Elisa Bianchi, Elisabetta Pupillo, Christian Lunetta, Lucio Tremolizzo, Giancarlo Logroscino, Adriano Chiò, Pierre Marie Preux & Ettore Beghi. (2016) Non-self-sufficiency as a primary outcome measure in ALS trials. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 17:1-2, pages 77-84.
Read now
Lucio Tremolizzo, Paolo Messina, Elisa Conti, Gessica Sala, Matteo Cecchi, Luisa Airoldi, Roberta Pastorelli, Elisabetta Pupillo, Monica Bandettini Di Poggio, Massimiliano Filosto, Christian Lunetta, Cristina Agliardi, Franca Guerini, Jessica Mandrioli, Andrea Calvo, Ettore Beghi, Carlo Ferrarese, M.S. Cotelli, M. Corbo, E. Maestri, E. Georgoulopoulou, L. Marzorati, E. Susani, A. Arosio, A. Chiò, G. Fuda & F. Pisa. (2014) Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 15:1-2, pages 98-105.
Read now

Articles from other publishers (52)

Elena Grossini, Fabiola De Marchi, Sakthipriyan Venkatesan, Angelica Mele, Daniela Ferrante & Letizia Mazzini. (2023) Effects of Acetyl-L-Carnitine on Oxidative Stress in Amyotrophic Lateral Sclerosis Patients: Evaluation on Plasma Markers and Members of the Neurovascular Unit. Antioxidants 12:10, pages 1887.
Crossref
Serena Sassi, Elisa Bianchi, Luca Diamanti, Danilo Tornabene, Elisabetta Sette, Doriana Medici, Sabrina Matà, Deborah Leccese, Martina Sperti, Ilaria Martinelli, Andrea Ghezzi, Jessica Mandrioli, Valentina Virginia Iuzzolino, Raffaele Dubbioso, Francesca Trojsi, Carla Passaniti, Giulia D’Alvano, Massimiliano Filosto, Alessandro Padovani, Letizia Mazzini, Fabiola De Marchi, Lucia Zinno, Andi Nuredini, Paolo Bongioanni, Cristina Dolciotti, Elena Canali, Giulia Toschi, Antonio Petrucci, Alessia Perna, Vittorio Riso, Maurizio Inghilleri, Laura Libonati, Chiara Cambieri & Elisabetta Pupillo. (2023) Retrospective observational study on the use of acetyl-l-carnitine in ALS. Journal of Neurology.
Crossref
Zeynep YILDIRIM, Dicle Naz TOKTAŞ, Öznur DEMİR, Zülfiye GÜL & Burcu ŞEN UTSUKARÇİ. (2023) Amyotrofik Lateral Skleroz Patofizyolojisi ve Tedavi YaklaşımlarıAn Evaluation of Amyotrophic Lateral Sclerosis and Current Situation in Its Treatment. Hacettepe University Journal of the Faculty of Pharmacy.
Crossref
Deepti Katiyar, Shipra Singhal, Priya Bansal, K. Nagarajan & Parul Grover. (2023) Nutraceuticals and phytotherapeutics for holistic management of amyotrophic lateral sclerosis. 3 Biotech 13:2.
Crossref
Minic Rajna, Stevic Zorica & Arsic Aleksandra. 2023. Diet and Nutrition in Neurological Disorders. Diet and Nutrition in Neurological Disorders 155 172 .
Audrey Labarre, Ericka Guitard, Gilles Tossing, Anik Forest, Eric Bareke, Marjorie Labrecque, Martine Tétreault, Matthieu Ruiz & J. Alex Parker. (2022) Fatty acids derived from the probiotic Lacticaseibacillus rhamnosus HA-114 suppress age-dependent neurodegeneration. Communications Biology 5:1.
Crossref
Viviana Moresi, Alessandra Renzini, Giorgia Cavioli, Marilia Seelaender, Dario Coletti, Giuseppe Gigli & Alessia Cedola. (2022) Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy. Metabolites 12:11, pages 1149.
Crossref
Sankar Simla Praveenraj, Sharma Sonali, Nikhilesh Anand, Hediyal Ahmed Tousif, Chandrasekaran Vichitra, Manjunath Kalyan, Perumalswamy Velumani Kanna, Kumar A. Chandana, Paneyala Shasthara, Arehally M. Mahalakshmi, Jian Yang, Seithikurippu R. Pandi-Perumal, Meena Kishore Sakharkar & Saravana Babu Chidambaram. (2022) The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders. Molecular Neurobiology 59:11, pages 6684-6700.
Crossref
David Mantle & Iain Parry Hargreaves. (2022) Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation. International Journal of Molecular Sciences 23:20, pages 12603.
Crossref
Andrew T. Nelson & Davide Trotti. (2022) Altered Bioenergetics and Metabolic Homeostasis in Amyotrophic Lateral Sclerosis. Neurotherapeutics 19:4, pages 1102-1118.
Crossref
Marco Ceccanti, Chiara Cambieri, Laura Libonati, Giorgio Tartaglia, Federica Moret, Matteo Garibaldi & Maurizio Inghilleri. (2022) Effects of Skin Stimulation on Sensory-Motor Networks Excitability: Possible Implications for Physical Training in Amyotrophic Lateral Sclerosis. Frontiers in Neurology 13.
Crossref
Anežka Vodičková, Shon A. Koren & Andrew P. Wojtovich. (2022) Site-specific mitochondrial dysfunction in neurodegeneration. Mitochondrion 64, pages 1-18.
Crossref
Ryan Massopust, Devin Juros, Dillon Shapiro, Mikayla Lopes, Saptarsi M. Haldar, Thomas Taetzsch & Gregorio Valdez. (2022) KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice. Neurobiology of Disease 162, pages 105583.
Crossref
Anna Andrea Lauer, Lea Victoria Griebsch, Sabrina Melanie Pilz, Daniel Janitschke, Elena Leoni Theiss, Jörg Reichrath, Christian Herr, Christoph Beisswenger, Robert Bals, Teresa Giovanna Valencak, Dorothea Portius, Heike Sabine Grimm, Tobias Hartmann & Marcus Otto Walter Grimm. (2021) Impact of Vitamin D3 Deficiency on Phosphatidylcholine-/Ethanolamine, Plasmalogen-, Lyso-Phosphatidylcholine-/Ethanolamine, Carnitine- and Triacyl Glyceride-Homeostasis in Neuroblastoma Cells and Murine Brain. Biomolecules 11:11, pages 1699.
Crossref
Eleonora Dalla Bella, Enrica Bersano, Giovanni Antonini, Giuseppe Borghero, Margherita Capasso, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Massimiliano Filosto, Fabio Giannini, Rossella Spataro, Christian Lunetta, Jessica Mandrioli, Sonia Messina, Maria Rosaria Monsurrò, Gabriele Mora, Nilo Riva, Romana Rizzi, Gabriele Siciliano, Vincenzo Silani, Isabella Simone, Gianni Sorarù, Valeria Tugnoli, Lorenzo Verriello, Paolo Volanti, Roberto Furlan, John M Nolan, Emmanuelle Abgueguen, Irene Tramacere & Giuseppe Lauria. (2021) The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial. Brain 144:9, pages 2635-2647.
Crossref
Naomi M. Fettig & Lisa C. Osborne. (2021) Direct and indirect effects of microbiota-derived metabolites on neuroinflammation in multiple sclerosis. Microbes and Infection 23:6-7, pages 104814.
Crossref
Aksu Gunay, Heather H. Shin, Oge Gozutok, Mukesh Gautam & P. Hande Ozdinler. (2021) Importance of lipids for upper motor neuron health and disease. Seminars in Cell & Developmental Biology 112, pages 92-104.
Crossref
Silvia Scaricamazza, Illari Salvatori, Alberto Ferri & Cristiana Valle. (2021) Skeletal Muscle in ALS: An Unappreciated Therapeutic Opportunity?. Cells 10:3, pages 525.
Crossref
Emily Beswick, Stella A Glasmacher, Rachel Dakin, Judith Newton, Alan Carson, Sharon Abrahams, Siddharthan Chandran & Suvankar Pal. (2021) Prospective observational cohort study of factors influencing trial participation in people with motor neuron disease (FIT-participation-MND): a protocol. BMJ Open 11:3, pages e044996.
Crossref
Katherine S. Watson, Imane Boukhloufi, Melissa Bowerman & Simon H. Parson. (2021) The Relationship between Body Composition, Fatty Acid Metabolism and Diet in Spinal Muscular Atrophy. Brain Sciences 11:2, pages 131.
Crossref
Daniele Orsucci, Elena Caldarazzo Ienco, Gabriele Siciliano & Michelangelo Mancuso. 2021. Clinical Bioenergetics. Clinical Bioenergetics 509 532 .
Danielle Beaulieu, Albert A. Taylor, Dustin Pierce, Jonavelle Cuerdo, Mark Schactman, Mike Keymer & David L. Ennist. 2021. Neurotherapeutics in the Era of Translational Medicine. Neurotherapeutics in the Era of Translational Medicine 333 366 .
Lu Chen, Yong Chen, Mingming Zhao, Lemin Zheng & Dongsheng Fan. (2020) Changes in the concentrations of trimethylamine N-oxide (TMAO) and its precursors in patients with amyotrophic lateral sclerosis. Scientific Reports 10:1.
Crossref
Michael S. Bereman, Kaylie I. Kirkwood, Tharani Sabaretnam, Sarah Furlong, Dominic B. Rowe, Gilles J. Guillemin, Allyson L. Mellinger & David C. Muddiman. (2020) Metabolite Profiling Reveals Predictive Biomarkers and the Absence of β-Methyl Amino- l -alanine in Plasma from Individuals Diagnosed with Amyotrophic Lateral Sclerosis . Journal of Proteome Research 19:8, pages 3276-3285.
Crossref
Heike J. Wobst, Korrie L. Mack, Dean G. Brown, Nicholas J. Brandon & James Shorter. (2020) The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future. Medicinal Research Reviews 40:4, pages 1352-1384.
Crossref
Débora Lanznaster, Charlotte Veyrat-Durebex, Patrick Vourc’h, Christian R. Andres, Hélène Blasco & Philippe Corcia. (2020) Metabolomics: A Tool to Understand the Impact of Genetic Mutations in Amyotrophic Lateral Sclerosis. Genes 11:5, pages 537.
Crossref
. (2020) 神経・筋疾患におけるL‐カルニチン欠乏症と治療. The Japanese Journal of SURGICAL METABOLISM and NUTRITION 54:2, pages 77-80.
Crossref
Coco Newton. 2020. Integrative and Functional Medical Nutrition Therapy. Integrative and Functional Medical Nutrition Therapy 863 912 .
Jose-Luis González De Aguilar. (2019) Lipid Biomarkers for Amyotrophic Lateral Sclerosis. Frontiers in Neurology 10.
Crossref
Ali Jawaid, Romesa Khan, Magdalini Polymenidou & Paul E. Schulz. (2018) Disease-modifying effects of metabolic perturbations in ALS/FTLD. Molecular Neurodegeneration 13:1.
Crossref
Efthimios DardiotisVasileios SiokasMaria SokratousZisis TsourisAthina-Maria AloizouDesponia FlorouMetaxia DastamaniAlexios-Fotios A. MentisAlexandros G. Brotis. (2018) Body mass index and survival from amyotrophic lateral sclerosis. Neurology Clinical Practice 8:5, pages 437-444.
Crossref
Simona Portaro, Teresa Brizzi, Antonino Naro, Valeria Conti Nibali, Rosa Morabito, Alessia Bramanti & Rocco Salvatore Calabrò. (2018) Acute onset of bulbar amyotrophic lateral sclerosis after flu – look at the differential diagnosis: A case report. Journal of International Medical Research 46:7, pages 2933-2937.
Crossref
Hélène Blasco, Franck Patin, Amandine Descat, Guillaume Garçon, Philippe Corcia, Patrick Gelé, Timothée Lenglet, Peter Bede, Vincent Meininger, David Devos, Jean François Gossens & Pierre-François Pradat. (2018) A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression. PLOS ONE 13:6, pages e0198116.
Crossref
Tijs Vandoorne, Katrien De Bock & Ludo Van Den Bosch. (2018) Energy metabolism in ALS: an underappreciated opportunity?. Acta Neuropathologica 135:4, pages 489-509.
Crossref
C.J.H.M. Klemann, J.E. Visser, L. Van Den Bosch, G.J.M. Martens & G. Poelmans. (2018) Integrated molecular landscape of amyotrophic lateral sclerosis provides insights into disease etiology. Brain Pathology 28:2, pages 203-211.
Crossref
Loqman A. Mohamed, Shashirekha Markandaiah, Silvia Bonanno, Piera Pasinelli & Davide Trotti. (2017) Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies. The AAPS Journal 19:6, pages 1600-1614.
Crossref
Nakul Katyal & Raghav Govindarajan. (2017) Shortcomings in the Current Amyotrophic Lateral Sclerosis Trials and Potential Solutions for Improvement. Frontiers in Neurology 8.
Crossref
Tesfaye W. Tefera & Karin Borges. (2017) Metabolic Dysfunctions in Amyotrophic Lateral Sclerosis Pathogenesis and Potential Metabolic Treatments. Frontiers in Neuroscience 10.
Crossref
Mehmet Akif Topcuoglu & Ethem Murat Arsava. 2017. Nutrition in Neurologic Disorders. Nutrition in Neurologic Disorders 155 206 .
Kazumoto ShibuyaSusanna B. ParkNimeshan GeevasingaParvathi MenonJames HowellsNeil G. SimonWilliam HuynhYu-ichi NotoJürgen GötzJillian J. KrilLars M. IttnerJohn HodgesGlenda HallidaySteve VucicMatthew C. Kiernan. (2016) Motor cortical function determines prognosis in sporadic ALS. Neurology 87:5, pages 513-520.
Crossref
R. Tortelli, M. Copetti, F. Panza, A. Fontana, R. Cortese, R. Capozzo, A. Introna, E. D'Errico, S. Zoccolella, S. Arcuti, D. Seripa, I. L. Simone & G. Logroscino. (2016) Time to generalization and prediction of survival in patients with amyotrophic lateral sclerosis: a retrospective observational study. European Journal of Neurology 23:6, pages 1117-1125.
Crossref
Conceicao Moura Mirian, Rita Carvalho Garbi Novaes Maria, SSP Zago Yuri, Junio Eduardo Emanoel & Augusto Casulari Luiz. (2016) Efficacy and effectiveness of drug treatments in amyotrophic lateral sclerosis: A systematic review with meta-analysis. African Journal of Pharmacy and Pharmacology 10:13, pages 257-269.
Crossref
H. Blasco, F. Patin, B. Madji Hounoum, P. H. Gordon, P. Vourc'h, C. R. Andres & P. Corcia. (2016) Metabolomics in amyotrophic lateral sclerosis: how far can it take us?. European Journal of Neurology 23:3, pages 447-454.
Crossref
Chafic Y. Karam, Sabrina Paganoni, Nanette Joyce, Gregory T. Carter & Richard Bedlack. (2014) Palliative Care Issues in Amyotrophic Lateral Sclerosis. American Journal of Hospice and Palliative Medicine® 33:1, pages 84-92.
Crossref
Irene Tramacere, Eleonora Dalla Bella, Adriano Chiò, Gabriele Mora, Graziella Filippini & Giuseppe Lauria. (2015) The MITOS system predicts long-term survival in amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery & Psychiatry 86:11, pages 1180-1185.
Crossref
Richard S. Bedlack, Nanette Joyce, Gregory T. Carter, Sabrina Paganoni & Chafic Karam. (2015) Complementary and Alternative Therapies in Amyotrophic Lateral Sclerosis. Neurologic Clinics 33:4, pages 909-936.
Crossref
Knut Hagen, Eiliv Brenner, Mattias Linde, Gøril Bruvik Gravdahl, Erling Andreas Tronvik, Morten Engstrøm, Ursula Sonnewald, Grethe Helde, Lars Jacob Stovner & Trond Sand. (2015) Acetyl-l-carnitine versus placebo for migraine prophylaxis: A randomized, triple-blind, crossover study. Cephalalgia 35:11, pages 987-995.
Crossref
Giuseppe Lauria, Eleonora Dalla Bella, Giovanni Antonini, Giuseppe Borghero, Margherita Capasso, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Roberto Eleopra, Raffaella Fazio, Massimiliano Filosto, Fabio Giannini, Enrico Granieri, Vincenzo La Bella, Giancarlo Logroscino, Jessica Mandrioli, Letizia Mazzini, Maria Rosaria Monsurrò, Gabriele Mora, Vladimiro Pietrini, Rocco Quatrale, Romana Rizzi, Fabrizio Salvi, Gabriele Siciliano, Gianni Sorarù, Paolo Volanti, Irene Tramacere & Graziella Filippini. (2015) Erythropoietin in amyotrophic lateral sclerosis: a multicentre, randomised, double blind, placebo controlled, phase III study. Journal of Neurology, Neurosurgery & Psychiatry 86:8, pages 879-886.
Crossref
Giovanni Pagano, Annarita Aiello Talamanca, Giuseppe Castello, Mario Cordero, Marco d'Ischia, Maria Gadaleta, Federico Pallardó, Sandra Petrović, Luca Tiano & Adriana Zatterale. (2014) Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials. International Journal of Molecular Sciences 15:11, pages 20169-20208.
Crossref
Hiroshi Mitsumoto, Benjamin R Brooks & Vincenzo Silani. (2014) Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?. The Lancet Neurology 13:11, pages 1127-1138.
Crossref
Sabrina Paganoni, Merit Cudkowicz & James D Berry. (2014) Outcome measures in amyotrophic lateral sclerosis clinical trials. Clinical Investigation 4:7, pages 605-618.
Crossref
Lucio Tremolizzo, Gessica Sala, Elisa Conti, Virginia Rodriguez-Menendez, Antonella Fogli, Angela Michelucci, Paolo Simi, Silvana Penco, Christian Lunetta, Massimo Corbo & Carlo Ferrarese. (2014) Valproate Treatment in an ALS Patient Carrying a c.194G>A Spastin Mutation and SMN2 Homozygous Deletion. Case Reports in Neurological Medicine 2014, pages 1-7.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.