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Original Articles

A multi-center screening trial of rasagiline in patients with amyotrophic lateral sclerosis: Possible mitochondrial biomarker target engagement

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Pages 345-352 | Received 07 Nov 2014, Accepted 01 Mar 2015, Published online: 02 Apr 2015

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Jeremy M. Shefner, Jinsy A. Andrews, Angela Genge, Carlayne Jackson, Noah Lechtzin, Timothy M. Miller, Bettina M. Cockroft, Lisa Meng, Jenny Wei, Andrew A. Wolff, Fady I. Malik, Cynthia Bodkin, Benjamin R. Brooks, James Caress, Annie Dionne, Dominic Fee, Stephen A. Goutman, Namita A. Goyal, Orla Hardiman, Ghazala Hayat, Terry Heiman-Patterson, Daragh Heitzman, Robert D. Henderson, Wendy Johnston, Chafic Karam, Matthew C. Kiernan, Stephen J. Kolb, Lawrence Korngut, Shafeeq Ladha, Genevieve Matte, Jesus S. Mora, Merrilee Needham, Bjorn Oskarsson, Gary L. Pattee, Erik P. Pioro, Michael Pulley, Dianna Quan, Kourosh Rezania, Kerri L. Schellenberg, David Schultz, Christen Shoesmith, Zachary Simmons, Jeffrey Statland, Shumaila Sultan, Andrea Swenson, Leonard H. Van Den Berg, Tuan Vu, Steve Vucic, Michael Weiss, Ashley Whyte-Rayson, James Wymer, Lorne Zinman & Stacy A. Rudnicki. (2021) A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 22:3-4, pages 287-299.
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Jeremy M. Shefner, Merit E. Cudkowicz, Orla Hardiman, Bettina M. Cockroft, Jacqueline H. Lee, Fady I. Malik, Lisa Meng, Stacy A. Rudnicki, Andrew A. Wolff & Jinsy A. Andrews. (2019) A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:7-8, pages 584-594.
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Arens Taga & Nicholas J. Maragakis. (2018) Current and emerging ALS biomarkers: utility and potential in clinical trials. Expert Review of Neurotherapeutics 18:11, pages 871-886.
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Ana Martinez, Maria del Valle Palomo Ruiz, Daniel I. Perez & Carmen Gil. (2017) Drugs in clinical development for the treatment of amyotrophic lateral sclerosis. Expert Opinion on Investigational Drugs 26:4, pages 403-414.
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Articles from other publishers (19)

Lu Yang, Yanfei Cheng, Yicheng Zhu, Liying Cui & Xiaoguang Li. (2023) The Serotonergic System and Amyotrophic Lateral Sclerosis: A Review of Current Evidence. Cellular and Molecular Neurobiology 43:6, pages 2387-2414.
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Pedro Soares, Catia Silva, Daniel Chavarria, Filomena S.G. Silva, Paulo J. Oliveira & Fernanda Borges. (2023) Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities. Ageing Research Reviews 83, pages 101790.
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Luca Muzio, Alma Ghirelli, Federica Agosta & Gianvito Martino. 2023. Motor System Disorders, Part II: Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment. Motor System Disorders, Part II: Spinal Cord, Neurodegenerative, and Cerebral Disorders and Treatment 523 537 .
Georgios Pampalakis, Georgios Angelis, Eleni Zingkou, Kostas Vekrellis & Georgia Sotiropoulou. (2022) A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis. Clinical and Translational Medicine 12:1.
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Anamaria Jurcau. (2021) Insights into the Pathogenesis of Neurodegenerative Diseases: Focus on Mitochondrial Dysfunction and Oxidative Stress. International Journal of Molecular Sciences 22:21, pages 11847.
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Heather M. Wilkins, Mazen M. Dimachkie & Abdulbaki Agbas. 2021. Amyotrophic Lateral Sclerosis. Amyotrophic Lateral Sclerosis 105 120 .
Matthew C. Kiernan, Steve Vucic, Kevin Talbot, Christopher J. McDermott, Orla Hardiman, Jeremy M. Shefner, Ammar Al-Chalabi, William Huynh, Merit Cudkowicz, Paul Talman, Leonard H. Van den Berg, Thanuja Dharmadasa, Paul Wicks, Claire Reilly & Martin R. Turner. (2020) Improving clinical trial outcomes in amyotrophic lateral sclerosis. Nature Reviews Neurology 17:2, pages 104-118.
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Dia Advani, Sudhanshu Sharma, Rahul Tripathi, Rohan Gupta, Asmita Jaiswal, Rashmi K. Ambasta & Pravir Kumar. 2021. Mitochondrial Dysfunction and Nanotherapeutics. Mitochondrial Dysfunction and Nanotherapeutics 91 137 .
Alizée Arnoux & Luc Dupuis. 2021. 5-HT2B Receptors. 5-HT2B Receptors 367 386 .
Eric D. Vidoni, In‐Young Choi, Phil Lee, Gregory Reed, Na Zhang, Joseph Pleen, Jonathan D. Mahnken, Jonathan Clutton, Annette Becker, Erica Sherry, Rebecca Bothwell, Heidi Anderson, Robert A. Harris, William Brooks, Heather M. Wilkins, Lisa Mosconi, Jeffrey M. Burns & Russell H. Swerdlow. (2020) Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients. Alzheimer's & Dementia 17:1, pages 7-17.
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Kirsten Hüning, Patrick Weydt, Michaela Hesse, Gülay Ates, Henning Cuhls & Lukas Radbruch. (2020) Pharmakologische und nicht pharmakologische Symptomtherapie bei amyotropher Lateralsklerose. Nervenheilkunde 39:12, pages 791-800.
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Adriano Chiò, Letizia Mazzini & Gabriele Mora. (2020) Disease-modifying therapies in amyotrophic lateral sclerosis. Neuropharmacology 167, pages 107986.
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Jeffrey M. Statland, Dan Moore, Yunxia Wang, Maureen Walsh, Tahseen Mozaffar, Lauren Elman, Sharon P. Nations, Hiroshi Mitsumoto, J. Americo Fernandes, David Saperstein, Ghazala Hayat, Laura Herbelin, Chafic Karam, Jonathan Katz, Heather M. Wilkins, Abdulbaki Agbas, Russell H. Swerdlow, Regina M. Santella, Mazen M. Dimachkie & Richard J. Barohn. (2018) Rasagiline for amyotrophic lateral sclerosis: A randomized, controlled trial. Muscle & Nerve 59:2, pages 201-207.
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Albert C Ludolph, Joachim Schuster, Johannes Dorst, Luc Dupuis, Jens Dreyhaupt, Jochen H Weishaupt, Jan Kassubek, Ulrike Weiland, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Berthold Schrank, Matthias Boentert, Alexander Emmer, Andreas Hermann, Daniel Zeller, Johannes Prudlo, Andrea S Winkler, Torsten Grehl, Michael T Heneka, Siw Wollebæk Johannesen, Bettina Göricke, Andreas Funke, Dagmar Kettemann, Robert Meyer, Thomas Meyer, Torsten Grehl, Kai Gruhn, Peter Schwenkreis, Philipp Stude, Michael T Heneka, Delia Kurzwelly, Andreas Hermann, Alexander Storch, Nicole Richter, Tobias Frank, Bettina Göricke, Katharina Hein, Alexander Emmer, Frank Hanisch, Dagmar Hanke, Torsten Kraya, Andreas Posa, Martina Romanakova, Susanne Schilling, Susanne Abdulla, Sebastian Böselt, Dagmar Hanke, Claas Janssen, Imken Lange, Xenia Kobeleva, Sonja Körner, Katja Kollewe, Alma Osmanovic, Susanne Petri, Nicole Scharn, Klaus J Rath, Christiane Dahms, Julian Grosskreutz, Anne Gunkel, Bianka Heiling, Thomas Ringer, Uta Smesny, Sarah Baumeister, Achim Berthele, Sarah Bublitz, Andrea S Winkler, Esra Akova-Öztürk, Matthias Boentert, Bianca Stubbe-Dräger, Alexandra Rahmann, Charlotte Young, Peter Young, Dobri Baldaranov, Ulrich Bogdahn, Siw Wollebæk Johannesen, Andrei Khomenko, Wilhelm Schulte-Mattler, Christina Stadler, Susanne Husung, Johannes Prudlo, Simone Tesar, Nigar Dargah-Zaden, Christina Last, Eva Langer, Albert C Ludolph, Jochen H Weishaupt, Ulrike Weiland, Ann-Sophie Lauenstein, Eckard Lensch, Carolyn Mc Farlane, Heike Fischer-Brasse, Klara Orbán, Bertold Schrank, Sonja Schürger, Stephan Klebe, Peter Kraft, Thomas Musacchio, Carola Seiler & Daniel Zeller. (2018) Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial. The Lancet Neurology 17:8, pages 681-688.
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Yannick Vermeiren, Jana Janssens, Debby Van Dam & Peter P. De Deyn. (2018) Serotonergic Dysfunction in Amyotrophic Lateral Sclerosis and Parkinson's Disease: Similar Mechanisms, Dissimilar Outcomes. Frontiers in Neuroscience 12.
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Loqman A. Mohamed, Shashirekha Markandaiah, Silvia Bonanno, Piera Pasinelli & Davide Trotti. (2017) Blood–Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies. The AAPS Journal 19:6, pages 1600-1614.
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Heather M. Wilkins, Jonathan D. Mahnken, Paul Welch, Rebecca Bothwell, Scott Koppel, Richard L. Jackson, Jeffrey M. Burns & Russell H. Swerdlow. (2017) A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer’s Disease Subjects: Results of a Single-Arm, Pilot Trial. Journal of Alzheimer's Disease 59:1, pages 291-300.
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Russell H. Swerdlow. (2016) Bioenergetics and metabolism: a bench to bedside perspective. Journal of Neurochemistry 139:S2, pages 126-135.
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Yuan-Jin Zhang & Dong-Sheng Fan. (2016) Elimination Rate of Serum Lactate is Correlated with Amyotrophic Lateral Sclerosis Progression. Chinese Medical Journal 129:1, pages 28-32.
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