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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 16, 2015 - Issue 5-6
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ORIGINAL ARTICLE

Whole genome analyses reveal no pathogenetic single nucleotide or structural differences between monozygotic twins discordant for amyotrophic lateral sclerosis

Karyn Meltz SteinbergThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA
,
Thomas J. NicholasThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA
,
Daniel C. KoboldtThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA
,
Bing YuDepartment of Medical Genomics, Royal Prince Alfred Hospital and Sydney Medical School, The University of Sydney, New South Wales, Australia
,
Elaine MardisThe Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA
&
Roger PamphlettThe Stacey MND Laboratory, Discipline of Pathology, Sydney Medical School, The Brain & Mind Research Institute, The University of Sydney, New South Wales, AustraliaCorrespondence[email protected]
Pages 385-392 | Received 21 Nov 2014, Accepted 08 Mar 2015, Published online: 11 May 2015

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Angeline S. Andrew, Katie M. O’Brien, Brian P. Jackson, Dale P. Sandler, Wendy E. Kaye, Laurie Wagner, Elijah W. Stommel, D. Kevin Horton, Paul Mehta & Clarice R. Weinberg. (2020) Keratinous biomarker of mercury exposure associated with amyotrophic lateral sclerosis risk in a nationwide U.S. study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 21:5-6, pages 420-427.
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Afnan A Alsultan, Rachel Waller, Paul R Heath & Janine Kirby. (2016) The genetics of amyotrophic lateral sclerosis: current insights. Degenerative Neurological and Neuromuscular Disease 6, pages 49-64.
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Yi-Min Sun, Wan-Li Yang, Ekaterina Rogaeva, Anthony E. Lang, Jian Wang & Ming Zhang. (2023) Genetic and Epigenetic Study of Monozygotic Twins Affected by Parkinson’s Disease. Clinical and Translational Neuroscience 7:2, pages 11.
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Diane B. Re, Beizhan Yan, Lilian Calderón-Garcidueñas, Angeline S. Andrew, Maeve Tischbein & Elijah W. Stommel. (2022) A perspective on persistent toxicants in veterans and amyotrophic lateral sclerosis: identifying exposures determining higher ALS risk. Journal of Neurology 269:5, pages 2359-2377.
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Angeline Andrew, Jie Zhou, Jiang Gui, Xun Shi, Meifang Li, Antoinette Harrison, Bart Guetti, Ramaa Nathan, Tanya Butt, Daniel Peipert, Maeve Tischbein, Erik P. Pioro, Elijah Stommel & Walter Bradley. (2022) ALS risk factors: Industrial airborne chemical releases. Environmental Pollution 295, pages 118658.
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Nirmal Vadgama, Alan Pittman, Michael Simpson, Niranjanan Nirmalananthan, Robin Murray, Takeo Yoshikawa, Peter De Rijk, Elliott Rees, George Kirov, Deborah Hughes, Tomas Fitzgerald, Mark Kristiansen, Kerra Pearce, Eliza Cerveira, Qihui Zhu, Chengsheng Zhang, Charles Lee, John Hardy & Jamal Nasir. (2019) De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes. European Journal of Human Genetics 27:7, pages 1121-1133.
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Mark P. Umstad, Lucas Calais-Ferreira, Katrina J. Scurrah, Judith G. Hall & Jeffrey M. Craig. 2019. Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics. Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics 387 414 .
Jane Alana Parkin Kullmann, Susan Hayes & Roger Pamphlett. (2018) Is psychological stress a predisposing factor for amyotrophic lateral sclerosis (ALS)? An online international case-control study of premorbid life events, occupational stress, resilience and anxiety. PLOS ONE 13:9, pages e0204424.
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M. Leija-Salazar, C. Piette & C. Proukakis. (2018) Review: Somatic mutations in neurodegeneration. Neuropathology and Applied Neurobiology 44:3, pages 267-285.
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Mark T. W. Ebbert, Rebecca J. Lank & Veronique V. Belzil. 2018. RNA Metabolism in Neurodegenerative Diseases. RNA Metabolism in Neurodegenerative Diseases 1 29 .
Yuejuan Xu, Tingting Li, Tian Pu, Ruixue Cao, Fei Long, Sun Chen, Kun Sun & Rang Xu. (2017) Copy Number Variants and Exome Sequencing Analysis in Six Pairs of Chinese Monozygotic Twins Discordant for Congenital Heart Disease. Twin Research and Human Genetics 20:6, pages 521-532.
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Paul E. Young, Stephen Kum Jew, Michael E. Buckland, Roger Pamphlett & Catherine M. Suter. (2017) Epigenetic differences between monozygotic twins discordant for amyotrophic lateral sclerosis (ALS) provide clues to disease pathogenesis. PLOS ONE 12:8, pages e0182638.
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Mannie Man Wai Lam, Jonathan P. Mapletoft & Matthew S. Miller. (2016) Abnormal regulation of the antiviral response in neurological/neurodegenerative diseases. Cytokine 88, pages 251-258.
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Larry Lam, Lydia Chin, Ramesh C. Halder, Bien Sagong, Sam Famenini, James Sayre, Dennis Montoya, Liudmilla Rubbi, Matteo Pellegrini & Milan Fiala. (2016) Epigenetic changes in T‐cell and monocyte signatures and production of neurotoxic cytokines in ALS patients. The FASEB Journal 30:10, pages 3461-3473.
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Veronique V. Belzil, Rebecca B. Katzman & Leonard Petrucelli. (2016) ALS and FTD: an epigenetic perspective. Acta Neuropathologica 132:4, pages 487-502.
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Bryan Maloney & Debomoy K Lahiri. (2016) Epigenetics of dementia: understanding the disease as a transformation rather than a state. The Lancet Neurology 15:7, pages 760-774.
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Nan Lyu, Li-Li Guan, Hong Ma, Xi-Jin Wang, Bao-Ming Wu, Fan-Hong Shang, Dan Wang, Hong Wen & Xin Yu. (2016) Failure to Identify Somatic Mutations in Monozygotic Twins Discordant for Schizophrenia by Whole Exome Sequencing. Chinese Medical Journal 129:6, pages 690-695.
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Rong Zhang, Holger Thiele, Peter Bartmann, Alina C. Hilger, Christoph Berg, Ulrike Herberg, Dietrich Klingmüller, Peter Nürnberg, Michael Ludwig & Heiko Reutter. (2015) Whole-Exome Sequencing in Nine Monozygotic Discordant Twins. Twin Research and Human Genetics 19:1, pages 60-65.
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V. Moresi, N. Marroncelli, E. Pigna & S. Adamo. 2016. Medical Epigenetics. Medical Epigenetics 315 333 .

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