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Research Article

A randomized, placebo-controlled, double-blind phase IIb trial evaluating the safety and efficacy of tirasemtiv in patients with amyotrophic lateral sclerosis

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Pages 426-435 | Received 01 Oct 2015, Accepted 05 Dec 2015, Published online: 16 Mar 2016

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Benjamin Rix Brooks, Erik P. Pioro, Danielle Beaulieu, Albert A. Taylor, Mark Schactman, Mike Keymer, Wendy Agnese, Johnna Perdrizet, Stephen Apple & David L. Ennist. (2022) Evidence for generalizability of edaravone efficacy using a novel machine learning risk-based subgroup analysis tool. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 23:1-2, pages 49-57.
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Jeremy M. Shefner, Jinsy A. Andrews, Angela Genge, Carlayne Jackson, Noah Lechtzin, Timothy M. Miller, Bettina M. Cockroft, Lisa Meng, Jenny Wei, Andrew A. Wolff, Fady I. Malik, Cynthia Bodkin, Benjamin R. Brooks, James Caress, Annie Dionne, Dominic Fee, Stephen A. Goutman, Namita A. Goyal, Orla Hardiman, Ghazala Hayat, Terry Heiman-Patterson, Daragh Heitzman, Robert D. Henderson, Wendy Johnston, Chafic Karam, Matthew C. Kiernan, Stephen J. Kolb, Lawrence Korngut, Shafeeq Ladha, Genevieve Matte, Jesus S. Mora, Merrilee Needham, Bjorn Oskarsson, Gary L. Pattee, Erik P. Pioro, Michael Pulley, Dianna Quan, Kourosh Rezania, Kerri L. Schellenberg, David Schultz, Christen Shoesmith, Zachary Simmons, Jeffrey Statland, Shumaila Sultan, Andrea Swenson, Leonard H. Van Den Berg, Tuan Vu, Steve Vucic, Michael Weiss, Ashley Whyte-Rayson, James Wymer, Lorne Zinman & Stacy A. Rudnicki. (2021) A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 22:3-4, pages 287-299.
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Jeremy M. Shefner, Merit E. Cudkowicz, Orla Hardiman, Bettina M. Cockroft, Jacqueline H. Lee, Fady I. Malik, Lisa Meng, Stacy A. Rudnicki, Andrew A. Wolff & Jinsy A. Andrews. (2019) A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20:7-8, pages 584-594.
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Jinsy A. Andrews, Merit E. Cudkowicz, Orla Hardiman, Lisa Meng, Amy Bian, Jacqueline Lee, Andrew A. Wolff, Fady I. Malik & Jeremy M. Shefner. (2018) VITALITY-ALS, a phase III trial of tirasemtiv, a selective fast skeletal muscle troponin activator, as a potential treatment for patients with amyotrophic lateral sclerosis: study design and baseline characteristics. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 19:3-4, pages 259-266.
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Susana Pinto & Mamede de Carvalho. (2017) Comparison of slow and forced vital capacities on ability to predict survival in ALS. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 18:7-8, pages 528-533.
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Ammar Al-ChalabiLeo M. A. HeunksZoltán Papp & Piero Pollesello. (2019) Potential of the Cardiovascular Drug Levosimendan in the Management of Amyotrophic Lateral Sclerosis: An Overview of a Working Hypothesis. Journal of Cardiovascular Pharmacology 74:5, pages 389-399.
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