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Research Article

Financial impact of a novel pre-eclampsia diagnostic test versus standard practice: a decision-analytic modeling analysis from a UK healthcare payer perspective

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Pages 728-737 | Accepted 22 Oct 2010, Published online: 07 Dec 2010

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Valentina Giardini, Sara Allievi, Carla Fornari, Roberta Rovelli, Giancarlo Cesana, Alessandra Lafranconi & Patrizia Vergani. (2021) Management of pregnancy blood pressure increase in the emergency room: role of PlGF-based biochemical markers and relative economic impact. The Journal of Maternal-Fetal & Neonatal Medicine 34:7, pages 1083-1090.
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Martin Hund, Wilma Verhagen-Kamerbeek, Manfred Reim, Diethelm Messinger, Reinhard van der Does & Holger Stepan. (2015) Influence of the sFlt-1/PlGF ratio on clinical decision-making in women with suspected preeclampsia – the PreOS study protocol. Hypertension in Pregnancy 34:1, pages 102-115.
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Patrícia G. Teixeira, Zilma S. N. Reis, Silvia P. Andrade, Cézar A. Rezende, Eura M. Lage, Elizabeth P. Velloso, Carolina A. S. Santana & Antônio C. V. Cabral. (2013) Presymptomatic prediction of preeclampsia with angiogenic factors, in high risk pregnant women. Hypertension in Pregnancy 32:3, pages 312-320.
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Nandini Hadker, Suchita Garg, Cory Costanzo, Wim van der Helm & James Creeden. (2013) Are there financial savings associated with supplementing current diagnostic practice for preeclampsia with a novel test? Learnings from a modeling analysis from a German payer perspective. Hypertension in Pregnancy 32:2, pages 105-119.
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Tinnakorn Chaiworapongsa, Roberto Romero, Zeynep Alpay Savasan, Juan Pedro Kusanovic, Giovanna Ogge, Eleazar Soto, Zhong Dong, Adi Tarca, Bhatti Gaurav & Sonia S. Hassan. (2011) Maternal plasma concentrations of angiogenic/anti-angiogenic factors are of prognostic value in patients presenting to the obstetrical triage area with the suspicion of preeclampsia. The Journal of Maternal-Fetal & Neonatal Medicine 24:10, pages 1187-1207.
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Jessica J Miller, Victoria Higgins, Nir Melamed, Michelle Hladunewich, Liyan Ma, Paul M Yip & Lei Fu. (2023) Clinical Validation of the sFlt-1:PlGF Ratio as a Biomarker for Preeclampsia Diagnosis in a High-Risk Obstetrics Unit. The Journal of Applied Laboratory Medicine 8:3, pages 457-468.
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María José Rivera Mena, Andrés Felipe Mercado González, María del Cisne Vega Cobos & Gabriela Michelle Vanegas Contreras. (2023) Doppler de arterias uterinas para tamizaje y prevención de preeclampsia. Tesla Revista Científica 3:1, pages e119.
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Max Hackelöer, Leon Schmidt & Stefan Verlohren. (2022) New advances in prediction and surveillance of preeclampsia: role of machine learning approaches and remote monitoring. Archives of Gynecology and Obstetrics 308:6, pages 1663-1677.
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Hongya Zhang, Xuexiang Li, Tianying Zhang, Qianhui Zhou & Cong Zhang. (2022) Establishment and validation of a predictive model of preeclampsia based on transcriptional signatures of 43 genes in decidua basalis and peripheral blood. BMC Bioinformatics 23:1.
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Marianna Danielli, Roisin C. Thomas, Clare L. Gillies, Jiamiao Hu, Kamlesh Khunti & Bee Kang Tan. (2022) Blood biomarkers to predict the onset of pre-eclampsia: A systematic review and meta-analysis. Heliyon 8:11, pages e11226.
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Sarah Heimberger, Joana Lopes Perdigao, Ariel Mueller, Gabriel Arenas, Melissa Kuriloff, Colleen Duncan, Courtney Amegashie & Sarosh Rana. (2022) Women’s perspectives and attitudes towards the utility of angiogenic biomarkers in preeclampsia. Pregnancy Hypertension 28, pages 109-113.
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Neily Zakiyah, Robin Tuytten, Philip N. Baker, Louise C. Kenny, Maarten J. Postma & Antoinette D. I. van Asselt. (2022) Early cost-effectiveness analysis of screening for preeclampsia in nulliparous women: A modelling approach in European high-income settings. PLOS ONE 17:4, pages e0267313.
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Frederic Chantraine, Kristel Van Calsteren, Roland Devlieger, Damien Gruson, Joachim Van Keirsbilck, Ana Dubon Garcia, Katleen Vandeweyer & Leonardo Gucciardo. (2021) Enhancing the value of the sFlt-1/PlGF ratio for the prediction of preeclampsia: Cost analysis from the Belgian healthcare payers’ perspective. Pregnancy Hypertension 26, pages 31-37.
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Liona C. Poon, Laura A. Magee, Stefan Verlohren, Andrew Shennan, Peter Dadelszen, Eyal Sheiner, Eran Hadar, Gerard Visser, Fabricio Da Silva Costa, Anil Kapur, Fionnuala McAuliffe, Amala Nazareth, Muna Tahlak, Anne B. Kihara, Hema Divakar, H. David McIntyre, Vincenzo Berghella, Huixia Yang, Roberto Romero, Kypros H. Nicolaides, Nir Melamed & Moshe Hod. (2021) A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre‐eclampsia. International Journal of Gynecology & Obstetrics 154:S1, pages 3-31.
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Anil Kapur & Moshe Hod. (2020) Maternal health and non‐communicable disease prevention: An investment case for the post COVID‐19 world and need for better health economic data. International Journal of Gynecology & Obstetrics 150:2, pages 151-158.
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Silvi Shah. 2020. Obstetric and Gynecologic Nephrology. Obstetric and Gynecologic Nephrology 11 23 .
KE Duhig, PT Seed, JE Myers, R Bahl, G Bambridge, S Barnfield, J Ficquet, JC Girling, A Khalil, AH Shennan, LC Chappell & RM Hunter. (2019) Placental growth factor testing for suspected pre‐eclampsia: a cost‐effectiveness analysis. BJOG: An International Journal of Obstetrics & Gynaecology 126:11, pages 1390-1398.
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Dietmar Schlembach, Martin Hund, Cyrill Wolf & Manu Vatish. (2019) Diagnostic utility of angiogenic biomarkers in pregnant women with suspected preeclampsia: A health economics review. Pregnancy Hypertension 17, pages 28-35.
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M.a José Alcaine Villarroya, Eva M. Barrenechea Iparraguirre, Elena Casals, Concepción González Rodríguez, Inmaculada Martín Navas, Hada Macher Manzano, M. Concepción Martínez Camarasa, Daniel Morell García, Helena Méndez Sol, Irene Rosas Allende, Elvira Tejedor Hernández & Belén Prieto García. (2019) Utilidad de los marcadores bioquímicos de preeclampsia. Revista del Laboratorio Clínico 12:3, pages e9-e24.
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Elizabeth A. Phipps, Ravi Thadhani, Thomas Benzing & S. Ananth Karumanchi. (2019) Pre-eclampsia: pathogenesis, novel diagnostics and therapies. Nature Reviews Nephrology 15:5, pages 275-289.
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D. Ortved, T. L.‐A. Hawkins, J.‐A. Johnson, J. Hyett & A. Metcalfe. (2019) Cost‐effectiveness of first‐trimester screening with early preventative use of aspirin in women at high risk of early‐onset pre‐eclampsia. Ultrasound in Obstetrics & Gynecology 53:2, pages 239-244.
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Ignacio Herraiz García, Elisa Llurba Olive, Alberto Galindo Izquierdo & Stefan Verlohren. (2019) Actualización del diagnóstico y el pronóstico de la preeclampsia en embarazos únicos con la ayuda del cociente sFlt-1/PlGF. Progresos de Obstetricia y Ginecología.
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Yuan Shen, Qiang Li, Xiaoning Liu, Shengbin Xiao & Hong Yan. (2019) Training and financial intervention for encouraging maternal health service utilization. Medicine 98:45, pages e17709.
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Maria Portelli & Byron Baron. (2018) Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns. Journal of Pregnancy 2018, pages 1-23.
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Christopher P Price, Jane Wolstenholme, Patrick McGinley & Andrew St John. (2017) Translational health economics: The key to accountable adoption of in vitro diagnostic technologies. Health Services Management Research 31:1, pages 43-50.
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Kate Duhig, Brooke Vandermolen & Andrew Shennan. (2018) Recent advances in the diagnosis and management of pre-eclampsia. F1000Research 7, pages 242.
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Linda J. E. Meertens, Hubertina C. J. Scheepers, Jessica P. M. M. Willemse, Marc E. A. Spaanderman & Luc J. M. Smits. (2018) Should women be advised to use calcium supplements during pregnancy? A decision analysis. Maternal & Child Nutrition 14:1, pages e12479.
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Zoë M. McLaren, Alana Sharp, John P. Hessburg, Amir Sabet Sarvestani, Ethan Parker, James Akazili, Timothy R.B. Johnson & Kathleen H. Sienko. (2017) Cost effectiveness of medical devices to diagnose pre-eclampsia in low-resource settings. Development Engineering 2, pages 99-106.
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Eliza F. Chakravarty & Virginia Steen. 2017. Scleroderma. Scleroderma 551 561 .
M. Vatish, T. Strunz‐McKendry, M. Hund, D. Allegranza, C. Wolf & C. Smare. (2016) sFlt‐1/PlGF ratio test for pre‐eclampsia: an economic assessment for the UK. Ultrasound in Obstetrics & Gynecology 48:6, pages 765-771.
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Geoff K Frampton, Jeremy Jones, Micah Rose & Liz Payne. (2016) Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid to the assessment of women with suspected pre-eclampsia: systematic review and economic analysis. Health Technology Assessment 20:87, pages 1-160.
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Suzy Duckworth, Lucy C. Chappell, Paul T. Seed, Lucy Mackillop, Andrew H. Shennan & Rachael Hunter. (2016) Placental Growth Factor (PlGF) in Women with Suspected Pre-Eclampsia Prior to 35 Weeks’ Gestation: A Budget Impact Analysis. PLOS ONE 11:10, pages e0164276.
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Neily Zakiyah, Maarten J. Postma, Philip N. Baker & Antoinette D. I. van Asselt. (2015) Pre-eclampsia Diagnosis and Treatment Options: A Review of Published Economic Assessments. PharmacoEconomics 33:10, pages 1069-1082.
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Ulrik Dolberg Anderson, Magnus Gram, Bo Åkerström & Stefan R. Hansson. (2015) First Trimester Prediction of Preeclampsia. Current Hypertension Reports 17:9.
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Cindy M. Anderson, Jody L. Ralph, Michelle L. Wright, Bryan Linggi & Joyce E. Ohm. (2013) DNA Methylation as a Biomarker for Preeclampsia. Biological Research For Nursing 16:4, pages 409-420.
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Lucy C Chappell, Kate Bramham & Andrew H Shennan. (2014) Short-term prediction of preeclampsia: how close are we?. Biomarkers in Medicine 8:4, pages 455-458.
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Melanie Griffin & Andrew H Shennan. (2014) Clinical applications of biomarkers in preeclampsia. Biomarkers in Medicine 8:4, pages 459-470.
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C Hyde & S Thornton. (2013) Does screening for pre-eclampsia make sense?. BJOG: An International Journal of Obstetrics & Gynaecology 120:10, pages 1168-1170.
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WT Schnettler, D Dukhovny, J Wenger, S Salahuddin, SJ Ralston & S Rana. (2013) Cost and resource implications with serum angiogenic factor estimation in the triage of pre-eclampsia. BJOG: An International Journal of Obstetrics & Gynaecology 120:10, pages 1224-1232.
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Damien Gruson, Clemence Djuidjé Yuemo, Jean-François Classen, Thibault Lepoutre, Nicolas Piquard & Frederic Debiève. (2013) First trimester placental growth factor and soluble fms-like tyrosine kinase 1 are significantly related to PAPP-A levels. Clinical Chemistry and Laboratory Medicine (CCLM) 51:4, pages e49-e51.
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Vikram Sinai Talaulikar & Hassan Shehata. (2012) Uric acid: is it time to give up routine testing in management of pre-eclampsia?. Obstetric Medicine 5:3, pages 119-123.
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Reem Mustafa, Sana Ahmed, Anu Gupta & Rocco C. Venuto. (2012) A Comprehensive Review of Hypertension in Pregnancy. Journal of Pregnancy 2012, pages 1-19.
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Virginia Steen & Eliza F. Chakravarty. 2012. Scleroderma. Scleroderma 547 557 .
Amir Shmueli, Hamutal Meiri & Ron Gonen. (2012) Economic assessment of screening for pre‐eclampsia. Prenatal Diagnosis 32:1, pages 29-38.
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