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Clinical Focus: Diabetes Management in the Hospital Setting and Transitioning Back to Primary Care

Efficacy and Safety of Canagliflozin Treatment in Older Subjects With Type 2 Diabetes Mellitus: A Randomized Trial

, MD, , MD, PhD, , MS, , BS & , MD
Pages 72-84 | Published online: 13 Mar 2015

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Parvej Khan, Shubhashree Venkatesh, Rizwana Parveen, Pinki Mishra, Seema Jain & Nidhi Agarwal. (2023) Longitudinal efficacy of Ertugliflozin in type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Expert Opinion on Pharmacotherapy 0:0, pages 1-12.
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Hiroyuki Ito, Suzuko Matsumoto, Takuma Izutsu, Eiji Kusano, Shinya Nishio, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane, Shigenori Ando & Emiko Tsugami. (2019) Comparison of the changes in the factors associated with the renal prognosis of non-elderly and elderly subjects treated with empagliflozin- a retrospective observation study in Japanese patients with type 2 diabetes. Diabetes, Metabolic Syndrome and Obesity 12, pages 1783-1794.
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Katherine Merton, Michael J. Davies, Ujjwala Vijapurkar, Doreen Inman & Gary Meininger. (2018) Achieving the composite endpoint of HbA1c, body weight, and systolic blood pressure reduction with canagliflozin in patients with type 2 diabetes. Current Medical Research and Opinion 34:2, pages 313-318.
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Konstantinos P. Imprialos, Konstantinos Stavropoulos, Michael Doumas, Asterios Karagiannis & Vasilios G. Athyros. (2017) The effect of SGLT2 inhibitors on cardiovascular events and renal function. Expert Review of Clinical Pharmacology 10:11, pages 1251-1261.
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Michael J Davies, Katherine W Merton, Ujjwala Vijapurkar, Dainius A Balis & Mehul Desai. (2017) Canagliflozin improves risk factors of metabolic syndrome in patients with type 2 diabetes mellitus and metabolic syndrome. Diabetes, Metabolic Syndrome and Obesity 10, pages 47-55.
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Rong Qiu, Dainius Balis, John Xie, Michael J. Davies, Mehul Desai & Gary Meininger. (2017) Longer-term safety and tolerability of canagliflozin in patients with type 2 diabetes: a pooled analysis. Current Medical Research and Opinion 33:3, pages 553-562.
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Thomas C. Blevins & Azeez Farooki. (2017) Bone effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus. Postgraduate Medicine 129:1, pages 159-168.
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Guntram Schernthaner, Fernando J. Lavalle-González, Jaime A. Davidson, Holly Jodon, Ujjwala Vijapurkar, Rong Qiu & William Canovatchel. (2016) Canagliflozin provides greater attainment of both HbA1c and body weight reduction versus sitagliptin in patients with type 2 diabetes. Postgraduate Medicine 128:8, pages 725-730.
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Maria Alba, John Xie, Albert Fung & Mehul Desai. (2016) The effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on mineral metabolism and bone in patients with type 2 diabetes mellitus. Current Medical Research and Opinion 32:8, pages 1375-1385.
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Karen S.L. Lam, Chun Chung Chow, Kathryn C.B. Tan, Ronald C.W. Ma, Alice P.S. Kong, Peter C.Y. Tong, Man Wo Tsang, Tak Mao Chan, Sydney C.W. Tang, Ka Kui Lee, Wing Yee So & Brian Tomlinson. (2016) Practical considerations for the use of sodium–glucose co-transporter type 2 inhibitors in treating hyperglycemia in type 2 diabetes. Current Medical Research and Opinion 32:6, pages 1097-1108.
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Sarah Thayer, Wing Chow, Stephanie Korrer & Richard Aguilar. (2016) Real-world evaluation of glycemic control among patients with type 2 diabetes mellitus treated with canagliflozin versus dipeptidyl peptidase-4 inhibitors. Current Medical Research and Opinion 32:6, pages 1087-1096.
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Lawrence Blonde, Kaj Stenlöf, Albert Fung, John Xie, William Canovatchel & Gary Meininger. (2016) Effects of canagliflozin on body weight and body composition in patients with type 2 diabetes over 104 weeks. Postgraduate Medicine 128:4, pages 371-380.
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Matthew R. Weir. (2016) The kidney and type 2 diabetes mellitus: therapeutic implications of SGLT2 inhibitors. Postgraduate Medicine 128:3, pages 290-298.
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Fernando J. Lavalle-González, Freddy G. Eliaschewitz, Sonia Cerdas, Maria Del Pilar Chacon, Cindy Tong & Maria Alba. (2016) Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus from Latin America. Current Medical Research and Opinion 32:3, pages 427-439.
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Rizwana Parveen, Nidhi Bharal Agarwal, Neelam Kaushal, Ghanshyam Mali & Sheikh Raisuddin. (2016) Efficacy and safety of canagliflozin in type 2 diabetes mellitus: systematic review of randomized controlled trials. Expert Opinion on Pharmacotherapy 17:1, pages 105-115.
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Vlado Perkovic, Meg Jardine, Ujjwala Vijapurkar & Gary Meininger. (2015) Renal effects of canagliflozin in type 2 diabetes mellitus. Current Medical Research and Opinion 31:12, pages 2219-2231.
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Molly G. Minze, Robin L. Koffarnus, Trista A. Bailey, Sandy Diec & Krystal L. Edwards. (2015) Sodium-glucose co-transporter 2 inhibitors: evidence and place in therapy. Expert Review of Endocrinology & Metabolism 10:6, pages 645-661.
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Lawrence Blonde, Vincent Woo, Chantal Mathieu, Jacqueline Yee, Ujjwala Vijapurkar, William Canovatchel & Gary Meininger. (2015) Achievement of treatment goals with canagliflozin in patients with type 2 diabetes mellitus: a pooled analysis of randomized controlled trials. Current Medical Research and Opinion 31:11, pages 1993-2000.
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Jennifer N. Clements, Heather P. Whitley, Jennifer J. D’Souza, Benjamin Gross, Rick Hess, Sara Reece, Chad Gentry & Kayce Shealy. (2015) Sodium glucose co-transporter inhibitors for the management of diabetes mellitus: an opinion paper from the Endocrine and Metabolism Practice and Research Network of the American College of Clinical Pharmacy. Current Medical Research and Opinion 31:9, pages 1733-1741.
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L.M. Meckley, G. Miyasato, F. Kokkotos, J. Bumbaugh & R.A. Bailey. (2015) An observational study of glycemic control in canagliflozin treated patients. Current Medical Research and Opinion 31:8, pages 1479-1486.
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Erin K. Buysman, Wing Chow, Henry J. Henk & Marcia F.T. Rupnow. (2015) Characteristics and short-term outcomes of patients with type 2 diabetes mellitus treated with canagliflozin in a real-world setting. Current Medical Research and Opinion 31:1, pages 137-143.
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Michael A Nauck. (2014) Update on developments with SGLT2 inhibitors in the management of type 2 diabetes. Drug Design, Development and Therapy 8, pages 1380-1380.
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Rosemarie Lajara. (2014) The potential role of sodium glucose co-transporter 2 inhibitors in combination therapy for type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 15:17, pages 2565-2585.
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Brian K Irons & Molly G Minze. (2014) Drug treatment of type 2 diabetes mellitus in patients for whom metformin is contraindicated. Diabetes, Metabolic Syndrome and Obesity 7, pages 15-24.
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Jaime A. Davidson & Louis Kuritzky. (2014) Sodium Glucose Co-Transporter 2 Inhibitors and Their Mechanism for Improving Glycemia in Patients with Type 2 Diabetes. Postgraduate Medicine 126:6, pages 33-48.
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Matthew R. Weir, Irina Kline, John Xie, Robert Edwards & Keith Usiskin. (2014) Effect of canagliflozin on serum electrolytes in patients with type 2 diabetes in relation to estimated glomerular filtration rate (eGFR). Current Medical Research and Opinion 30:9, pages 1759-1768.
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Stephen Brunton & Timothy S. Reid. (2014) Canagliflozin, a Sodium Glucose Co-transporter 2 Inhibitor, for the Management of Type 2 Diabetes. Hospital Practice 42:3, pages 96-108.
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Paul Nyirjesy, Jack D. Sobel, Albert Fung, Cristiana Mayer, George Capuano, Kirk Ways & Keith Usiskin. (2014) Genital mycotic infections with canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus: a pooled analysis of clinical studies. Current Medical Research and Opinion 30:6, pages 1109-1119.
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Keith Usiskin, Irina Kline, Albert Fung, Cristiana Mayer & Gary Meininger. (2014) Safety and Tolerability of Canagliflozin in Patients With Type 2 Diabetes Mellitus: Pooled Analysis of Phase 3 Study Results. Postgraduate Medicine 126:3, pages 16-34.
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Kaj Stenlöf, William T. Cefalu, Kyoung-Ah Kim, Esteban Jodar, Maria Alba, Robert Edwards, Cindy Tong, William Canovatchel & Gary Meininger. (2014) Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study. Current Medical Research and Opinion 30:2, pages 163-175.
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Lindsay E. Nicolle, George Capuano, Albert Fung & Keith Usiskin. (2014) Urinary Tract Infection in Randomized Phase III Studies of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor. Postgraduate Medicine 126:1, pages 7-17.
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Eric Dietrich, Jason Powell & James R Taylor. (2013) Canagliflozin: a novel treatment option for type 2 diabetes. Drug Design, Development and Therapy 7, pages 1399-1408.
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