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Original Article

Does a Healthy Weight Body Mass Index at Onset of Idiopathic Intracranial Hypertension Change the Outcomes? A United Kingdom Prospective Cohort Study

ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon
Received 02 Oct 2023, Accepted 08 Apr 2024, Published online: 22 Apr 2024

Figures & data

Table 1. Baseline table by baseline BMI.

Table 2. Baseline estimates and trajectory from regression modelling for obesity BMI cut-off (30 kg/m2).

Figure 1. Longitudinal visual data from baseline visit for IIH patients categorised by whether BMI < 30 or ≥30 kg/m2, and LOESS smoothers added to show trends across the categories.

(a) LogMAR visual acuity (logunits)
(b) Perimetric mean deviation measured by Humphrey visual field 24-2 testing (dB)
(c) Retinal nerve fibre layer thickness measured on optical coherence tomography (µm)
(d) Total retinal thickness of optic nerve head measured on optical coherence tomography (µm)
(e) Macular ganglion cell layer volume measured on optical coherence tomography (mm3).
Figure 1. Longitudinal visual data from baseline visit for IIH patients categorised by whether BMI < 30 or ≥30 kg/m2, and LOESS smoothers added to show trends across the categories.

Figure 2. Longitudinal headache data from baseline visit for IIH patients categorised by whether BMI <30 or ≥30 kg/m2, and LOESS smoothers added to show trends across the categories.

(a) Headache frequency (days per month)
(b) Migraine-like headache frequency (days per month)
(c) Headache mean severity of predominant headache (0–10 numerical rating scale)
(d) Headache Impact Test 6 (HIT6) (quality of life measure score 36–78).
Figure 2. Longitudinal headache data from baseline visit for IIH patients categorised by whether BMI <30 or ≥30 kg/m2, and LOESS smoothers added to show trends across the categories.

Figure 3. Longitudinal visual data from baseline visit for IIH patients categorised baseline BMI group, and LOESS smoothers added to show trends across the categories.

(a) LogMAR visual acuity (logunits)
(b) Perimetric mean deviation measured by Humphrey visual field 24-2 testing (dB)
(c) Retinal nerve fibre layer thickness measured on optical coherence tomography (µm)
(d) Total retinal thickness of optic nerve head measured on optical coherence tomography (µm)
(e) Macular ganglion cell layer volume measured on optical coherence tomography (mm3).
Figure 3. Longitudinal visual data from baseline visit for IIH patients categorised baseline BMI group, and LOESS smoothers added to show trends across the categories.

Table 3. Baseline estimates and trajectory for visual and headache outcomes by baseline BMI from regression modelling.

Figure 4. Longitudinal headache data from baseline visit for IIH patients categorised by baseline BMI group, and LOESS smoothers added to show trends across the categories.

(a) Headache frequency (days per month)
(b) Migraine-like headache frequency (days per month)
(c) Headache mean severity of predominant headache (0–10 numerical rating scale)
(d) Headache Impact Test 6 (HIT6) (quality of life measure score 36–78).
Figure 4. Longitudinal headache data from baseline visit for IIH patients categorised by baseline BMI group, and LOESS smoothers added to show trends across the categories.

Data availability statement

Professor Sinclair takes full responsibility for the data, the analyses and interpretation, and the conduct of the research. She has full access to all the data and has the right to publish any and all data separate and apart from any sponsor. Proposals for data access should be made to the corresponding author. Reasonable scientifically sound proposals, from appropriately qualified research groups, will provide data beginning 12 months and ending 3 years after the publication of this article to researchers whose proposed use of the data is approved by the corresponding author. Requesters will need to sign a data access agreement, which will cover the terms and conditions of the release of data and will include publication requirements, authorship, acknowledgements, and obligations for the responsible use of data.