Does a Healthy Weight Body Mass Index at Onset of Idiopathic Intracranial Hypertension Change the Outcomes? A United Kingdom Prospective Cohort Study

References

• Yiangou A, Mollan SP, Sinclair AJ. Idiopathic intracranial hypertension: a step change in understanding the disease mechanisms. Nat Rev Neurol. 2023;19(12):769–785. doi:10.1038/s41582-023-00893-0.
   PubMed Web of Science ®Google Scholar
• Adderley NJ, Subramanian A, Nirantharakumar K, et al. Association between idiopathic intracranial hypertension and risk of cardiovascular diseases in women in the United Kingdom. JAMA Neurol. 2019;76(9):1088–1098. doi:10.1001/jamaneurol.2019.1812.
   PubMed Web of Science ®Google Scholar
• Mollan SP, Davies B, Silver NC, et al. Idiopathic intracranial hypertension: consensus guidelines on management. J Neurol Neurosurg Psychiatry. 2018;89(10):1088–1100. doi:10.1136/jnnp-2017-317440.
   PubMed Web of Science ®Google Scholar
• Grech O, Clouter A, Mitchell JL, et al. Cognitive performance in idiopathic intracranial hypertension and relevance of intracranial pressure. Brain Commun. 2021;3:fcab202. doi:10.1093/braincomms/fcab202.
   PubMedGoogle Scholar
• Thaller M, Homer V, Hyder Y, et al. The idiopathic intracranial hypertension prospective cohort study: evaluation of prognostic factors and outcomes. J Neurol. 2023;270(2):851–863. doi:10.1007/s00415-022-11402-6.
   PubMed Web of Science ®Google Scholar
• Adderley NJ, Subramanian A, Perrins M, Nirantharakumar K, Mollan SP, Sinclair AJ. Headache, opiate use, and prescribing trends in women with idiopathic intracranial hypertension: a population-based matched cohort study. Neurology. 2022;99:e1968–1978. doi:10.1212/WNL.0000000000201064.
   PubMed Web of Science ®Google Scholar
• Mollan SP, Wakerley BR, Alimajstorovic Z, et al. Intracranial pressure directly predicts headache morbidity in idiopathic intracranial hypertension. J Headache Pain. 2021;22(1):118. doi:10.1186/s10194-021-01321-8.
   PubMed Web of Science ®Google Scholar
• Hyder YF, Homer V, Thaller M, et al. Defining the phenotype and prognosis of people with idiopathic intracranial hypertension after cerebrospinal fluid diversion surgery. Am J Ophthalmol. 2023;250:70–81. doi:10.1016/j.ajo.2023.01.016.
   PubMed Web of Science ®Google Scholar
• Bruce BB, Kedar S, Van Stavern GP, Corbett JJ, Newman NJ, Biousse V. Atypical idiopathic intracranial hypertension: normal BMI and older patients. Neurology. 2010;74(22):1827–1832. doi:10.1212/WNL.0b013e3181e0f838.
   PubMed Web of Science ®Google Scholar
• World Health Organisation. Body mass index – BMI [Online]. https://www.who.int/europe/news-room/fact-sheets/item/a-healthy-lifestyle---who-recommendations. 2010. Accessed July 27, 2023.
   Google Scholar
• Consultation WHOE. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157–163. doi:10.1016/S0140-6736(03)15268-3.
   PubMed Web of Science ®Google Scholar
• National Institute for Health and Care Excellence. Obesity: identification, assessment and management clinical guideline [CG189]. 2014.
   Google Scholar
• Hornby C, Botfield H, O’Reilly MW, et al. Evaluating the fat distribution in idiopathic intracranial hypertension using dual-energy X-ray absorptiometry scanning. Neuroophthalmology. 2018;42:99–104. doi:10.1080/01658107.2017.1334218.
   PubMed Web of Science ®Google Scholar
• Hornby C, Mollan SP, Botfield H, O’Reilly MW, Sinclair AJ. Metabolic concepts in idiopathic intracranial hypertension and their potential for therapeutic intervention. J Neuroophthalmol. 2018;38:522–530. doi:10.1097/WNO.0000000000000684.
   PubMed Web of Science ®Google Scholar
• Fric R, Pripp AH, Eide PK. Cardiovascular risk factors in Chiari malformation and idiopathic intracranial hypertension. Brain Behav. 2017;7:e00677. doi:10.1002/brb3.677.
   PubMed Web of Science ®Google Scholar
• Thaller M, Mytton J, Wakerley BR, Mollan SP, Sinclair AJ. Idiopathic intracranial hypertension: evaluation of births and fertility through the hospital episode statistics dataset. BJOG. 2022;129(12):2019–2027. doi:10.1111/1471-0528.17241.
   PubMed Web of Science ®Google Scholar
• Alimajstorovic Z, Pascual-Baixauli E, Hawkes CA, et al. Cerebrospinal fluid dynamics modulation by diet and cytokines in rats. Fluids Barriers CNS. 2020;17(1):10. doi:10.1186/s12987-020-0168-z.
   PubMed Web of Science ®Google Scholar
• Westgate CS, Botfield HF, Alimajstorovic Z, et al. Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension. JCI Insight. 2021;6:e145346. doi:10.1172/jci.insight.145346.
   PubMed Web of Science ®Google Scholar
• Westgate CSJ, Markey K, Mitchell JL, et al. Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension. Eur J Endocrinol. 2022;187:323–333. doi:10.1530/EJE-22-0108.
   PubMed Web of Science ®Google Scholar
• O’Reilly MW, Westgate CS, Hornby C, et al. A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics. JCI Insight. 2019;4. doi:10.1172/jci.insight.125348.
   Web of Science ®Google Scholar
• Thaller M, Sinclair AJ, Tsermoulas G, Mollan SP. Considerations from venous stenosis to metabolic underpinnings in idiopathic intracranial hypertension. Cephalalgia. 2023;43(6):3331024231184445. doi:10.1177/03331024231184445.
   Web of Science ®Google Scholar
• Fargen KM, Coffman S, Torosian T, Brinjikji W, Nye BL, Hui F. “Idiopathic” intracranial hypertension: an update from neurointerventional research for clinicians. Cephalalgia. 2023;43(4):3331024231161323. doi:10.1177/03331024231161323.
   Web of Science ®Google Scholar
• Mollan SP, Tahrani AA, Sinclair AJ. The potentially modifiable risk factor in idiopathic intracranial hypertension: body weight. Neurol Clin Pract. 2021;11:e504–e507. doi:10.1212/CPJ.0000000000001063.
   PubMedGoogle Scholar
• Thaller M, Tsermoulas G, Sun R, Mollan SP, Sinclair AJ. Negative impact of COVID-19 lockdown on papilloedema and idiopathic intracranial hypertension. J Neurol Neurosurg Psychiatry. 2021;92(7):795–797. doi:10.1136/jnnp-2020-325519.
   PubMed Web of Science ®Google Scholar
• Mollan SP, Mitchell JL, Ottridge RS, et al. Effectiveness of bariatric surgery vs community weight management intervention for the treatment of idiopathic intracranial hypertension: a randomized clinical trial. JAMA Neurol. 2021;78(6):678–686. doi:10.1001/jamaneurol.2021.0659.
   PubMed Web of Science ®Google Scholar
• Sinclair AJ, Burdon MA, Nightingale PG, et al. Low energy diet and intracranial pressure in women with idiopathic intracranial hypertension: prospective cohort study. BMJ. 2010;341(jul07 2):c2701. doi:10.1136/bmj.c2701.
   PubMedGoogle Scholar
• Mollan SP, Mitchell JL, Yiangou A, et al. Association of amount of weight lost after bariatric surgery with intracranial pressure in women with idiopathic intracranial hypertension. Neurology. 2022;99:e1090–e1099. doi:10.1212/WNL.0000000000200839.
   PubMed Web of Science ®Google Scholar
• Wall M, Kupersmith MJ, Kieburtz KD, et al. The idiopathic intracranial hypertension treatment trial: clinical profile at baseline. JAMA Neurol. 2014;71(6):693–701. doi:10.1001/jamaneurol.2014.133.
   PubMed Web of Science ®Google Scholar
• Sharma B, Seervi N, Sharma V, Panagariya A, Goel D. Clinical and radiological profile of 122 cases of idiopathic intracranial hypertension in a tertiary care centre of India: an observational study. Neurol India. 2022;70(2):704–709. doi:10.4103/0028-3886.344644.
   PubMed Web of Science ®Google Scholar
• Friedman DI, Liu GT, Digre KB. Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children. Neurology. 2013;81(13):1159–1165. doi:10.1212/WNL.0b013e3182a55f17.
   PubMed Web of Science ®Google Scholar
• Mollan SP, Chong YJ, Grech O, Sinclair AJ, Wakerley BR. Current perspectives on idiopathic intracranial hypertension without papilloedema. Life (Basel). 2021;11(6). doi:10.3390/life11060472.
   Web of Science ®Google Scholar
• R Core Team. R: a language and environment for statistical computing [Online]. https://www.R-project.org/.
   Google Scholar
• Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. J Stat Softw. 2015;67(1):1–48. doi:10.18637/jss.v067.i01.
   Web of Science ®Google Scholar
• Vijay V, Mollan SP, Mitchell JL, et al. Using optical coherence tomography as a surrogate of measurements of intracranial pressure in idiopathic intracranial hypertension. JAMA Ophthalmol. 2020;138(12):1264–1271. doi:10.1001/jamaophthalmol.2020.4242.
   PubMed Web of Science ®Google Scholar
• Mitchell JL, Lyons HS, Walker JK, et al. The effect of exenatide on intracranial pressure in idiopathic intracranial hypertension: a randomised clinical trial. Brain. 2023;146:1821–1830. doi:10.1093/brain/awad003.
   PubMed Web of Science ®Google Scholar
• Mollan SP, Hornby C, Mitchell J, Sinclair AJ. Evaluation and management of adult idiopathic intracranial hypertension. Pract Neurol. 2018;18(6):485–488. doi:10.1136/practneurol-2018-002009.
   PubMedGoogle Scholar
• Mollan SP, Aguiar M, Evison F, Frew E, Sinclair AJ. The expanding burden of idiopathic intracranial hypertension. Eye (Lond). 2019;33(3):478–485. doi:10.1038/s41433-018-0238-5.
   PubMed Web of Science ®Google Scholar
• Chen BS, Newman NJ, Biousse V. Atypical presentations of idiopathic intracranial hypertension. Taiwan J Ophthalmol. 2021;11(1):25–38. doi:10.4103/tjo.tjo_69_20.
   PubMedGoogle Scholar
• Thaller M, Wakerley BR, Abbott S, Tahrani AA, Mollan SP, Sinclair AJ. Managing idiopathic intracranial hypertension in pregnancy: practical advice. Pract Neurol. 2022;22(4):295–300. doi:10.1136/practneurol-2021-003152.
   PubMedGoogle Scholar
• Aguiar M, Frew E, Mollan SP, et al. The health economic evaluation of bariatric surgery versus a community weight management intervention analysis from the idiopathic intracranial hypertension weight trial (IIH:WT). Life (Basel). 2021;11(5):409. doi:10.3390/life11050409.
   PubMed Web of Science ®Google Scholar
• Saxena P, Prakash A, Nigam A, Mishra A. Polycystic ovary syndrome: is obesity a sine qua non? A clinical, hormonal, and metabolic assessment in relation to body mass index. Indian J Endocrinol Metab. 2012;16:996–999. doi:10.4103/2230-8210.103011.
   PubMedGoogle Scholar
• Nestler JE, Jakubowicz DJ. Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens. J Clin Endocrinol Metab. 1997;82:4075–4079. doi:10.1210/jc.82.12.4075.
   PubMed Web of Science ®Google Scholar
• Glueck CJ, Golnik KC, Aregawi D, Goldenberg N, Sieve L, Wang P. Changes in weight, papilledema, headache, visual field, and life status in response to diet and metformin in women with idiopathic intracranial hypertension with and without concurrent polycystic ovary syndrome or hyperinsulinemia. Transl Res. 2006;148:215–222. doi:10.1016/j.trsl.2006.05.003.
   PubMed Web of Science ®Google Scholar
• Toosy S, Sodi R, Pappachan JM. Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach. J Diabetes Metab Disord. 2018;17(2):277–285. doi:10.1007/s40200-018-0371-5.
   PubMed Web of Science ®Google Scholar
• Laurie SS, Lee SMC, Macias BR, et al. Optic disc edema and choroidal engorgement in astronauts during spaceflight and individuals exposed to bed rest. JAMA Ophthalmol. 2020;138(2):165–172. doi:10.1001/jamaophthalmol.2019.5261.
   PubMed Web of Science ®Google Scholar
• Scott RA, Tarver WJ, Brunstetter TJ, Urquieta E. Optic nerve tortuosity on earth and in space. Aerosp Med Hum Perform. 2020;91:91–97. doi:10.3357/AMHP.5406.2020.
   PubMed Web of Science ®Google Scholar
• Mollan SP, Bodoza S, Ni Mhealoid A, et al. Visual field pointwise analysis of the idiopathic intracranial hypertension weight trial (IIH:WT). Transl Vis Sci Technol. 2023;12:1. doi:10.1167/tvst.12.5.1.
   PubMed Web of Science ®Google Scholar
• Mollan SP, Fraser CL, Digre KB, et al. Guidelines of the international headache society for controlled clinical trials in idiopathic intracranial hypertension. Cephalalgia. 2023;43(8):3331024231197118. doi:10.1177/03331024231197118.
   Web of Science ®Google Scholar
• Mollan SP, Momin SNA, Khatkar PS, Grech O, Sinclair AJ, Tsermoulas G. A neuro-ophthalmologist’s guide to advances in intracranial pressure measurements. Eye Brain. 2023;15:113–124. doi:10.2147/EB.S404642.
   PubMed Web of Science ®Google Scholar
• Scotton WJ, Mollan SP, Walters T, et al. Characterising the patient experience of diagnostic lumbar puncture in idiopathic intracranial hypertension: a cross-sectional online survey. BMJ Open. 2018;8(5):e020445. doi:10.1136/bmjopen-2017-020445.
   PubMed Web of Science ®Google Scholar
• Hoffmann J, Mollan SP, Paemeleire K, Lampl C, Jensen RH, Sinclair AJ. European headache federation guideline on idiopathic intracranial hypertension. J Headache Pain. 2018;19(1):93. doi:10.1186/s10194-018-0919-2.
   PubMed Web of Science ®Google Scholar