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Original Articles: BiGART 2023 Issue

The impact of short-course hypofractionated radiotherapy on multimodality treatment utilisation, compliance, and outcome in glioblastoma patients: a Danish patterns of care study

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Pages 1511-1519 | Received 22 May 2023, Accepted 02 Jul 2023, Published online: 09 Aug 2023

Figures & data

Figure 1. Patterns of care over time in (a) absolute numbers and (b) relative percentages in the Danish glioblastoma cohort 2011–2019 (n = 2416). In Figure 1(a), no subdivision between S-CRT followed or not followed by adjuvant CT, S-RT followed or not followed by adjuvant CT, and S-CT followed or not followed by RT, is made. Note in 2015 and 2016 known registration gap in adjuvant chemotherapy at one hospital, explaining the lower percentage of S-CRT-CT in those years to an unknown extent. S: surgery; CT: chemotherapy; RT: radiotherapy; CRT: chemoradiotherapy.

Figure 1. Patterns of care over time in (a) absolute numbers and (b) relative percentages in the Danish glioblastoma cohort 2011–2019 (n = 2416). In Figure 1(a), no subdivision between S-CRT followed or not followed by adjuvant CT, S-RT followed or not followed by adjuvant CT, and S-CT followed or not followed by RT, is made. Note in 2015 and 2016 known registration gap in adjuvant chemotherapy at one hospital, explaining the lower percentage of S-CRT-CT in those years to an unknown extent. S: surgery; CT: chemotherapy; RT: radiotherapy; CRT: chemoradiotherapy.

Table 1. Patient, tumour, and treatment characteristics of 2416 glioblastoma patients in the Danish cohort 2011–2019, and specified for patients assigned to conventionally and short-course hypofractionated radiotherapy.

Figure 2. Utilisation of radiotherapy regimens for patients treated with postoperative radiotherapy over time in (a) absolute numbers and (b) relative percentages in the Danish glioblastoma cohort 2011–2019 (n = 2026). CT: chemotherapy; RT: radiotherapy; CRT: chemoradiotherapy.

Figure 2. Utilisation of radiotherapy regimens for patients treated with postoperative radiotherapy over time in (a) absolute numbers and (b) relative percentages in the Danish glioblastoma cohort 2011–2019 (n = 2026). CT: chemotherapy; RT: radiotherapy; CRT: chemoradiotherapy.

Figure 3. Treatment utilisation of and compliance with multimodality treatment, in patients treated with (a) conventionally fractionated and (b) short-course hypofractionated postoperative radiotherapy, in the Danish glioblastoma cohort 2011–2019.

Figure 3. Treatment utilisation of and compliance with multimodality treatment, in patients treated with (a) conventionally fractionated and (b) short-course hypofractionated postoperative radiotherapy, in the Danish glioblastoma cohort 2011–2019.

Figure 4. Utilisation of concomitant chemotherapy over time in patients treated with (a) conventionally fractionated (n = 1571) and (b) short-course hypofractionated postoperative radiotherapy (n = 388) in the Danish glioblastoma cohort 2011–2019.

Figure 4. Utilisation of concomitant chemotherapy over time in patients treated with (a) conventionally fractionated (n = 1571) and (b) short-course hypofractionated postoperative radiotherapy (n = 388) in the Danish glioblastoma cohort 2011–2019.

Figure 5. Compliance with postoperative radiotherapy over time in patients treated with (a) conventionally fractionated (n = 1571) and (b) short-course hypofractionated regimens (n = 388) in the Danish glioblastoma cohort 2011–2019. Numbers in (a) and (b) include both patients treated with radiotherapy-only and those treated with chemoradiotherapy.

Figure 5. Compliance with postoperative radiotherapy over time in patients treated with (a) conventionally fractionated (n = 1571) and (b) short-course hypofractionated regimens (n = 388) in the Danish glioblastoma cohort 2011–2019. Numbers in (a) and (b) include both patients treated with radiotherapy-only and those treated with chemoradiotherapy.
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Data availability statement

The used data are freely available by request to the Danish Clinical Quality Program – National Clinical Registries, Danish Neuro-Oncology Registry.

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