A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers

Figures & data

Figure 1. Study CONSORT diagram.

Figure 2. Procedural timeline.

Table 1. Summary characteristics of the sample receiving each treatment.

Treatment	N	Sex	Age	BMI	STAI Y2	DASS
			Mean (SEM)
Green tea	25	16F 9M	26.44 (1.57)	22.9 (0.56)	38.72 (1.46)	16.6 (0.68)
Rhodiola Combined	25 25	17F 8M 14F 11M	26.2 (1.13) 22.2 (0.74)	23.25 (0.63) 22.93 (0.52)	40.48 (1.24) 42.48 (1.43)	15.68 (0.63) 17.12 (0.74)
Placebo	25	17F 8M	25.56 (1.55)	23.69 (0.56)	43.12 (1.37)	15.96 (0.66)

Figure 3. Maps depicting comparison of resting state theta power by treatment (maps A, B, and C; positive values indicate COMBINED > effect in comparison). ROI midline frontal electrodes shown by • in A. (A): t-Statistic for comparison of theta band activity for eyes open COMBINED vs. PLACEBO; (B): and eyes open COMBINED vs. RHODIOLA; (C): t-Statistic for comparison of theta band activity for eyes closed COMBINED vs. PLACEBO. (D): Mean averaged ROI (SEM) midline frontal theta power eyes open; (E) and closed by treatment.

Figure 4. SACL Stress (A) and Arousal (B) response profile by treatment.

Figure 5. POMS subscale response profiles: (A) Tension-Anxiety; (B) Depression-Dejection; (C) Anger-Hostility; (D) Vigour-Activity; (E) Fatigue-Inertia; (F) Total Mood Disturbance score.

Figure 6. Response profiles for: (A) Bond-Lader Alertness; (B) STAI state anxiety.

Data availability statement

Due to its proprietary nature the study data cannot be made openly available.