Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine

Figures & data

Figure 1.  Structure of berberine.

Figure 2.  Benzoquinolizine-type DPP IV inhibitors.

Figure 3.  Structure of Cyanopyrrolidine inhibitor.

Figure 4.  Perspective cartoon view of DPP IV co-crystallized with cyanopyrrolidine inhibitor. [PDB code: 2G63[49]]

Figure 5.  Perspective cartoon view of the highest ranking binding mode of berberine, as suggested by the Chemgauss2 scoring function, docked in DPP IV. [PDB code: 2G63[49]]

Figure 6.  Detailed view of the docked berberine structure and the corresponding interacting amino-acid moieties within the binding site of DPP IV. [PDB code: 2G63[49]]

Figure 7.  The highest ranking binding mode of the cyanopyrolidine inhibitor as suggested by the docking-scoring conditions. (A) Detailed view of the docked structure and the corresponding interacting amino-acids. (B) Comparison between the docked conformer/pose of inhibitor cyanopyrolidine (green) as produced by the docking simulation and the crystallographic structure of this inhibitor within DPP IV (red, PDB code: 2G63).

Figure 8.  : The effect of variable berberine concentrations on the relative activity of DPP IV.