Figures & data
Figure 1. Synthesis of NSAID hydroxamic acids and their O-alkyl derivatives.
Table 1. Reaction conditions and analytical data for compounds 3a–i.
Table 2. Spectroscopic data and atom enumeration for compounds 3a–i.
Table 3. Antimicrobial activity of NSAID hydroxamic acid derivatives 3 and 4 determined by hole-plate diffusion method.
Table 4. Minimal inhibitory (MIC) and minimal microbicidal concentrations (MMcC) of NSAID hydroxamic acid derivatives 3 and 4 determined by microdilution broth methoda.
Figure 2. Dose-dependent inhibition of jack bean urease by NSAID hydroxamic acid derivatives: 3i (▴), 4a (♦), 4c (▪), 4e (*), 4h (•).
Table 5. Interaction with DPPH, in vitro inhibition of soybean lipoxygenase (LO), lipid peroxidation (LP), and theoretically calculated Clog P values.