Tissue concentrations of vancomycin and Moxifloxacin in periprosthetic infection in rats

Figures & data

Figure 1. Clinical appearance of osteomyelitis. Condyles of a control femur (A) and an infected femur (B).

Figure 2. Radiographical appearance of osteomyelitis. Left femur with implanted needle. Signs of osteomyelitis of the distal femur, arthritis of the knee, and osteomyelitis of the proximal tibia are apparent in the left leg.

Figure 3. Tissue to plasma ratio (mean ± SD) of Moxifloxacin concentrations (open columns) and vancomycin concentrations (closed columns) in lung, fat from the groin, muscle, and bone of rats after a 2-week intraperitoneal treatment with Moxifloxacin 10 mg/kg body weight twice daily or vancomycin 15 mg/kg twice daily. Muscle and bone specimens were taken separately from the left (infected) and right hind legs.

Plasma and tissue concentrations of Moxifloxacin and vancomycin in plasma, lung, fat from the groin, muscle and bone of rats following a 2–week intraperitoneal treatment with Moxifloxacin 10 mg/kg body weight twice daily or vancomycin 15 mg/kg daily. Muscle and bone specimens were taken separately from the left (infected) and right hind legs

	Vancomycin		Moxifloxacin
	mean (SD) median (range)	mean (SD) median (range)	mean (SD) median (range)	mean (SD) median (range)
Plasma (µg/mL)	3.52 (0.51)	3.16 (1.57–6.53)	0.34 (0.08)	0.25 (0.06–0.82)
Lung (µg/g)	5.35 (0.55)	4.68 (3.01–8.61)	1.37 (0.28)	1.14 (0.21–2.76)
Fat (µg/g)	4.40 (0.50)	4.92 (2.01–6.38)	0.68 (0.21)	0.52 (0.08–2.42)
Muscle (left) (µg/g)	1.93 (0.23) a	1.75 (1.10–3.33)	2.03 (0.46)	1.79 (0.24–4.46)
Muscle (right) (µg/g)	1.01 (0.10)	0.91 (0.58–1.55)	2.05 (0.47)	1.75 (0.26–4.71)
Bone (left) (µg/g)	1.45 (0.11) b	1.40 (0.84–2.19)	1.00 (0.17)	0.96 (0.21–1.90)
Bone (right) (µg/g)	1.28 (0.11)	1.24 (0.84–2.14)	1.00 (0.21)	0.93 (0.13–2.28)

^ap = 0.001 between left and right side,

^bp < 0.001 between left and right side.