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OncoImmunology Volume 4, 2015 - Issue 11
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Toward a rational design of combination therapy in cancer

Marie-Agnès DouceyLudwig Center for Cancer Research; University of Lausanne; Epilanges, SwitzerlandCorrespondence[email protected]
&
Ioannis XenariosVital-IT Systems Biology Division; SIB Swiss Institute of Bioinformatics; University of Lausanne; Lausanne, Switzerland
Article: e1046674 | Received 24 Apr 2015, Accepted 25 Apr 2015, Published online: 14 Sep 2015

Figures & data

Figure 1. (A) Workflow diagram of interfaced modeling and experimental approaches to discover treatments and pathways controlling TEM pro-angiogenic activity. Orange experimentation, blue: system modeling and green: validation. (B) In silico-predicted and experimentally validated perturbations transitioning two attractors corresponding to weakly angiogenic highly angiogenic blood and tumor TEM, respectively.

Figure 1. (A) Workflow diagram of interfaced modeling and experimental approaches to discover treatments and pathways controlling TEM pro-angiogenic activity. Orange experimentation, blue: system modeling and green: validation. (B) In silico-predicted and experimentally validated perturbations transitioning two attractors corresponding to weakly angiogenic highly angiogenic blood and tumor TEM, respectively.

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