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Review

Microexons: novel regulators of the transcriptome

, , & ORCID Icon
Pages 1-6 | Received 11 Aug 2017, Accepted 13 Feb 2018, Published online: 07 Aug 2018

Figures & data

Figure 1. Inclusion of microexons within the mRNA sequence might have profound functional consequences for protein translation and structure. A presence of microexon can result in open reading frame shift leading to premature stop codons and degradation of the mRNA (A). Inclusion of additional amino acids encoded by microexons can lead to changes in protein’s ability to interact with other proteins (B) or generate additional sites for post-translational modifications (C).

Figure 1. Inclusion of microexons within the mRNA sequence might have profound functional consequences for protein translation and structure. A presence of microexon can result in open reading frame shift leading to premature stop codons and degradation of the mRNA (A). Inclusion of additional amino acids encoded by microexons can lead to changes in protein’s ability to interact with other proteins (B) or generate additional sites for post-translational modifications (C).