Computational approaches for drug target identification in pathogenic diseases

Figures & data

Figure 1. Properties preferred in drug targets and computational methods for identifying targets based on them. The nature of the method as well as the questions that need can be addressed while choosing a protein as a potential drug target are also indicated.

Figure 2. Various levels of hierarchy at which a system can be studied to identify drug targets. Some are already being used widely, but some have the potential to be explored in the coming years for target discovery. The lower pyramid illustrates the different levels of organization in the cell, while the upper pyramid illustrates high order interactions, at cellular levels as well as organismal levels.