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Abstract
MiRNAs (miRNAs) are a class of small endogenous, noncoding RNAs with important roles in regulating gene expression known to play a role in many cellular functions including cellular differentiation, cell proliferation, cell development and functional regulation of the immune system, among others. As such, miRNAs are emerging not only as potential biomarkers but also as potential therapeutic targets. Here, we review the currently published work on miRNAs and renal transplantation as it pertains to ischemia–reperfusion injury, acute kidney injury, delayed graft function, calcineurin inhibitor toxicity, acute rejection, chronic allograft dysfunction and kidney fibrosis.
Financial & competing interests disclosure
The research results included in this report were supported by a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grant R01DK080074. This study was partially funded by the NIH. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.