The Clinical Efficacy of Three Different Follicle-Stimulating Hormones for Follicle Growth and Development in Long-Protocol Controlled Ovarian Hyperstimulation Treatment

Figures & data

Table 1 The General Characteristics Among the Normal-Response Populations ($\overline{X}$±s)

Groups	Age (Years)	AFC (Number)	BMI (kg/m^2)	AMH (ng/mL)	FSH (IU/L)	Years of Infertility
Gonal-f	31.77±3.45	12.24±3.37	20.87±2.401	3.029±0.937	7.17±1.7	3.6±2.6
Jinsaiheng	31.21±3.72	12.67±3.99	21.01±2.511	2.932±0.969	7.14±1.5	3.5±2.4
Lishenbao	31.70±3.85	12.05±3.824	21.16±2.421	2.887±0.918	7.23±1.7	3.9±2.9
P	0.442	0.418	0.653	0.493	0.899	0.538
F	0.819	0.874	0.427	0.709	0.107	0.620

Figure 1 (A) The growth of the first-largest follicle in the normal-response group. (B) The growth of the second-largest follicle in the normal-response group. (C) The growth of the third-largest follicle in the normal-response group.

Table 2 The Therapeutic Efficacy and Safety Among the Normal-Response Populations

Medication	Number of High-Quality Embryos	Number of Eggs Obtained	Number of Embryos Transferred	Implantation Rate	Clinical Pregnancy Rate	Early Miscarriage Rate	Incidence of Moderate to Severe OHSS	Number of Gn Days	Gn Dosage	The Follicle Distribution on the HCG Day
										Diameter of Follicle >20mm	Diameter of Follicle 18–20mm	Diameter of Follicle 16–18mm	Diameter of Follicle 14–16mm
Gonal-f	6.33±3.98	15.24±6.317	1.92±0.267	48.02%(85/177)	66.29%(59/89)	9.8%(6/61)	2.5%(3/120)	12.13±1.511	2427.13±723.266	0.55±0.92	2.04±1.68	3.66±2.26	2.84±2.22
Jinsaiheng	6.47±4.021	14.83±5.926	1.89±0.316	48.82%(83/170)	66.29%(59/89)	6.7%(4/60)	5.8%(7/120)	12.06±1.525	2484.13±800.676	0.74±1.10	2.12±1.79	3.14±1.99	2.38±2.24
Lishenbao	5.08±3.580	13.56±7.585	1.89±0.313	45.98%(80/174)	65.22%(60/92)	8.3%(5/60)	4.2%(5/120)	12.30±1.601	2793.20±841.540	0.67±1.12	1.72±1.84	3.03±1.89	2.45±2.32
P	0.010*	0.125	0.677	0.870	0.985	0.830	0.487	0.392	0.001*	0.358^Δ	0.198	0.041**	0.335
F or Chi-square value	4.48	1.683	0.391	0.298	0.031	0.546	1.670	0.938	8.077	1.031	1.637	3.222	1.097

Notes: *There was no difference between the two groups (Gonal-f and Jinsaiheng), but there was significant difference between the two groups and lishenbao; **there was significant difference between the two groups (Gonal-f and Lishenbao), but there was no difference between the two groups (Gonal-f and Jinsaiheng); ^Δit means nonparametric test.

Table 3 The General Characteristics Between High-Response Group ($\overline{X}$±s)

Groups	Age (Years)	AFC (Number)	BMI (kg/m^2)	AMH (ng/mL)	FSH (IU/L)	Years of Infertility
Gonal-f	31.50±3.149	15.50±3.908	20.752±2.171	6.17±2.414	6.62±1.63	3.9±2.5
Jinsaiheng	31.50±3.757	15.90±4.269	21.407±2.524	6.679±2.205	6.67±1.45	3.9±2.7
Lishenbao	31.48±3.397	15.26±4.615	20.737±2.703	6.649±2.098	6.43±1.37	3.7±1.8
P	1	0.711	0.241	0.988	0.654	0.879
F	0.000	0.342	1.433	0.012	0.426	0.129

Figure 2 (A) The growth of the first-largest follicle in the high-response group. (B) The growth of the second-largest follicle in the high-response group. (C) The growth of the third-largest follicle in the high-response group.

Table 4 Comparison of the Therapeutic Efficacy and Safety Among the High-Response Populations

Medication	Number of High-Quality Embryos	Number of Eggs Obtained	Number of Embryos Transferred	Implantation Rate	Clinical Pregnancy Rate	Early Miscarriage Rate	Incidence of Moderate to Severe OHSS	Number of Gn Days	Gn Dosage	The Follicle Distribution on the HCG Day
										Diameter of Follicle >20mm	Diameter of Follicle 18–20mm	Diameter of Follicle 16–18mm	Diameter of Follicle 14–16mm
Gonal-f	9.18±5.06	20.8±7.24	1.91±0.37	53.85%(35/65)	75%(24/32)	12%(3/25)	6%(4/60)	11.68±1.127	1838.92±514.172	0.88±1.21	2.95±2.27	4.95±2.68	5.33±3.41
Jinsaiheng	8.00±4.62	18.25±7.25	1.82±0.38	58.06%(36/62)	73.53%(25/34)	16%(4/25)	12%(7/60)	11.67±1.469	1992.23±497.992	0.77±1.14	3.11±2.56	4.48±2.73	4.87±3.2
Lishenbao	6.62±4.58	17.37±7.61	1.92±0.27	53.42%(39/73)	71.05%(27/38)	3.7%(1/27)	12%(7/60)	12.57±1.588	2304.07±803.163	0.66±1.10	2.60±1.70	4.43±2.72	4.36±2.76
P	0.004**	0.012**	0.436	0.861	0.961	0.334	0.703	0.000*	0.000*	0.560	0.483	0.521	0.244
F or Chi-square value	5.420	4.913	0.836	0.343	0.143	2.211	1.111	9.989	8.785	0.583	0.732	0.654	1.421

Notes: *There was no difference between the two groups (Gonal-f and Jinsaiheng), but there was significant difference between the two groups and lishenbao; **there was significant difference between the two groups (Gonal-f and Lishenbao), but there was no difference between the two groups (Gonal-f and Jinsaiheng).