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REVIEW

Tracking Research on Hemoglobin-Based Oxygen Carriers: A Scientometric Analysis and In-Depth Review

, , , , , , , & show all
Pages 2549-2571 | Received 13 Jun 2023, Accepted 04 Aug 2023, Published online: 24 Aug 2023

Figures & data

Figure 1 Flow chart of scientometric analysis.

Figure 1 Flow chart of scientometric analysis.

Figure 2 Annual publications between 1991–2022.

Figure 2 Annual publications between 1991–2022.

Figure 3 Distribution of major research directions.

Figure 3 Distribution of major research directions.

Table 1 The Top 10 Productive Countries/Regions Related to HBOCs Research

Figure 4 (A) Geographical distribution map based on the total publications of different countries/regions. (B) The changing trend of the annual publication quantity in the top ten countries/regions from 1991 to 2022. (C) The international collaborations’ visualization map of countries/regions.

Figure 4 (A) Geographical distribution map based on the total publications of different countries/regions. (B) The changing trend of the annual publication quantity in the top ten countries/regions from 1991 to 2022. (C) The international collaborations’ visualization map of countries/regions.

Table 2 The Top 10 Productive Institutions Related to HBOCs Research

Table 3 The Top 10 Authors with Most Publications Related to HBOCs Research

Table 4 The Top 20 Journals with Most Publications Related to HBOCs Research

Table 5 Top 20 Co-Cited Journals Related to HBOCs Research

Table 6 The Top 10 Cited References Related to HBOCs

Figure 5 Reference timeline view.

Figure 5 Reference timeline view.

Figure 6 (A) VOSviewer network map of co-occurrence analysis of all keywords of HBOCs-related studies. (B) Top 25 keywords with the strongest citation bursts on HBOCs from burst analysis of keywords.

Figure 6 (A) VOSviewer network map of co-occurrence analysis of all keywords of HBOCs-related studies. (B) Top 25 keywords with the strongest citation bursts on HBOCs from burst analysis of keywords.

Figure 7 (A) Type of HBOCs. (B) Physiological mechanism. (C) Clinical scenario. (D) Adverse event.

Figure 7 (A) Type of HBOCs. (B) Physiological mechanism. (C) Clinical scenario. (D) Adverse event.

Figure 8 Hemoglobin modifications mechanisms.

Figure 8 Hemoglobin modifications mechanisms.

Table 7 Physiochemical Parameters and their Active Mechanisms on HBOCs

Figure 9 The brief evaluation system for HBOCs in vivo and in vitro trials.

Figure 9 The brief evaluation system for HBOCs in vivo and in vitro trials.