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Drug, Healthcare and Patient Safety Volume 10, 2018 - Issue
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Review

Therapeutic potential of medicinal marijuana: an educational primer for health care professionals

Yara Mouhamed1 Graduate Diploma & Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada
,
Andrey Vishnyakov1 Graduate Diploma & Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada
,
Bessi Qorri2 Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada
,
Manpreet Sambi2 Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, Canada
,
SM Signy Frank1 Graduate Diploma & Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada
,
Catherine Nowierski1 Graduate Diploma & Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada
,
Anmol Lamba1 Graduate Diploma & Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada
,
Umrao Bhatti1 Graduate Diploma & Professional Master in Medical Sciences, School of Medicine, Queen’s University, Kingston, ON, Canada
&
Myron R Szewczuk2 Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON, CanadaCorrespondence[email protected]
 show all
Pages 45-66 | Published online: 11 Jun 2018

Figures & data

Figure 1 The endocannabinoid system and CB1/CB2 distribution. (A) The mechanism of action of the endocannabinoid system is depicted, with human endocannabinoids AEA or 2-AG binding to CB1 to initiate a signaling cascade through the release of neurotransmitters. THC is also able to bind to CB1, exerting its effects on the central nervous system and peripheral system. (B) Distribution of CB1 and CB2 in the body. CB1 is concentrated in the central and peripheral nervous systems. CB2 is more abundant in the immune system and, to a lesser degree, in the nervous system.

Abbreviations: CB1/CB2, cannabinoid receptor 1/cannabinoid receptor 2; AEA, anandamide; 2-AG, 2-arachidonooylglycerol; THC, (−)-Δ9-trans-(6aR,10aR)-tetrahydrocannabinol.
Figure 1 The endocannabinoid system and CB1/CB2 distribution. (A) The mechanism of action of the endocannabinoid system is depicted, with human endocannabinoids AEA or 2-AG binding to CB1 to initiate a signaling cascade through the release of neurotransmitters. THC is also able to bind to CB1, exerting its effects on the central nervous system and peripheral system. (B) Distribution of CB1 and CB2 in the body. CB1 is concentrated in the central and peripheral nervous systems. CB2 is more abundant in the immune system and, to a lesser degree, in the nervous system.

Figure 2 The effects of cannabis on the central nervous system. Brain areas in the central nervous system (in black) and their physiological functions (in red) are listed alongside potential effects of THC and CBD (in blue and green), respectively.

Abbreviations: THC, (−)-Δ9-trans-(6aR,10aR)-tetrahydrocannabinol; CBD, cannabidiol.
Figure 2 The effects of cannabis on the central nervous system. Brain areas in the central nervous system (in black) and their physiological functions (in red) are listed alongside potential effects of THC and CBD (in blue and green), respectively.

Table 1 Specific effects of THC in the peripheral system

Table 2 Mode of administration of Δ9-THC

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