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Diabetes, Metabolic Syndrome and Obesity Volume 15, 2022 - Issue
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REVIEW

Disrupted Alpha-Ketoglutarate Homeostasis: Understanding Kidney Diseases from the View of Metabolism and Beyond

Lijing Guo1 Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China;2 Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China
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Shihua Chen1 Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China;2 Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China
,
Liping Ou1 Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China;2 Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China
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Shangmei Li1 Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China
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Zhen-Nan Ye1 Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China;2 Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-1237-1971
ORCID Icon &
Hua-Feng Liu1 Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China;2 Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, People’s Republic of China
Pages 1961-1974 | Published online: 27 Jun 2022

Figures & data

Figure 1 Three major metabolic pathways that generating and consuming AKG. The left part shows TCA cycle, in which isocitrate is converted to AKG by IDH3 in mitochondrion, and subsequently AKG is catalyzed by α-KGDH to generate succinyl-CoA. The right part illustrates the other two signaling which utilize glutamine to generate AKG, namely glutaminase I pathway (occurring mostly in mitochondrion) and glutaminase II pathway (both in the cytosol and mitochondrion). Besides, AKG is also involved in amino acids metabolism, as demonstrated in the upper right.

Figure 1 Three major metabolic pathways that generating and consuming AKG. The left part shows TCA cycle, in which isocitrate is converted to AKG by IDH3 in mitochondrion, and subsequently AKG is catalyzed by α-KGDH to generate succinyl-CoA. The right part illustrates the other two signaling which utilize glutamine to generate AKG, namely glutaminase I pathway (occurring mostly in mitochondrion) and glutaminase II pathway (both in the cytosol and mitochondrion). Besides, AKG is also involved in amino acids metabolism, as demonstrated in the upper right.
 

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