Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases

Figures & data

Figure 1 Schematic representation of the fate of SLN through oral delivery.

Abbreviation: SLN, solid lipid nanoparticle.

Figure 2 Schematic representation of the fate of MSLN through oral delivery.

Abbreviations: MSLN, modified solid lipid nanoparticle; SLN, solid lipid nanoparticle.

Figure 3 Biodistribution of phytocompounds loaded in MSLN through oral delivery.

Abbreviation: MSLN, modified solid lipid nanoparticle.

Table 1 Phyto-bioactive compounds loaded in chitosan-coated solid lipid nanoparticles used in various disease models

Type of chitosan-modified solid lipid nanoparticles	Bioactive compounds	Disease models	References
Chitosan-coated solid lipid nanoparticles	Curcumin	Pancreatic cancer models	Thakkar et al^Citation181
	Resveratrol	Brain bioavailability studies	Ramalingam and Ko^Citation13
	Caffeic acid	Oral bioavailability studies	Fathi et al^Citation183
	Ferulic acid	Pancreatic cancer models	Thakkar et al^Citation181
Trimethyl chitosan-coated solid lipid nanoparticles	Curcumin	Brain bioavailability studies	Ramalingam and Ko^Citation7
	Resveratrol	Brain bioavailability studies	Ramalingam and Ko^Citation12,Citation13
N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles	Resveratrol	Brain bioavailability studies	Ramalingam and Ko^Citation12

Figure 4 Schematic representation of mucoadhesion of SLN or MSLN through oral delivery.

Abbreviations: MSLN, modified solid lipid nanoparticle; SLN, solid lipid nanoparticle.

ThakkarAChenreddySWangJPrabhuSFerulic acid combined with aspirin demonstrates chemopreventive potential towards pancreatic cancer when delivered using chitosan-coated solid-lipid nanoparticlesCell Biosci201554626301084

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RamalingamPKoYTValidated LC-MS/MS method for simultaneous quantification of resveratrol levels in mouse plasma and brain and its application to pharmacokinetic and brain distribution studiesJ Pharm Biomed Anal2016119717526657178

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FathiMMirlohiMVarshosazJMadaniGNovel caffeic acid nanocarrier: production, characterization, and release modelingJ Nanomater20132013434632

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RamalingamPKoYTEnhanced oral delivery of curcumin from N-trim-ethyl chitosan surface-modified solid lipid nanoparticles: pharmacokinetic and brain distribution evaluationsPharm Res201532238940225082210

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RamalingamPKoYTImproved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticlesColloids Surf B Biointerfaces2016139526126700233

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