Novel oral contraceptive for heavy menstrual bleeding: estradiol valerate and dienogest

Figures & data

Figure 1 Daily doses of E2V and DNG in the quadriphasic regimen.

Abbreviations: E2V, estradiol valerate; DNG, dienogest.

Table 1 Cost comparison of treatments for heavy menstrual bleeding³⁶

Drug	Annual Treatment Cost, Estimated (United States dollars)
Estradiol valerate/dienogest	$1120–$1136
Levonorgestrel IUD*	$844
Ibuprofen**	$22
Ethinyl estradiol/levonorgestrel	$358–$374
Micronized progesterone***	$1454–$1488
Medroxyprogesterone acetate****	$90–$180

Notes:

* One time cost does not reflect procedural service for insertion;

** assumes daily dose of ibuprofen 600 mg daily × 5 days, so 5 tablets;

*** assumes daily dose of 300 mg;

**** assumes daily dose of 10 mg although for very heavy bleeding 10 mg twice daily is needed.

Abbreviation: IUD, intrauterine device.

LethabyAECookeIReesMProgesterone or progestogen-releasing intrauterine systems for heavy menstrual bleedingCochrane Database Syst Rev200519CD00212616235297

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